P54811

PR
Gene name
cdc-48.1
Protein name
Transitional endoplasmic reticulum ATPase homolog 1
Names
Cell division cycle-related protein 48.1, p97/CDC48 homolog 1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C06A1.1
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

749-809 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54811

Entry ID Method Resolution Chain Position Source
AF-P54811-F1 Predicted AlphaFoldDB

No variants for P54811

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54811

No associated diseases with P54811

11 regional properties for P54811

Type Name Position InterPro Accession
domain CDC48, N-terminal subdomain 31 - 114 IPR003338
domain AAA+ ATPase domain 243 - 379 IPR003593-1
domain AAA+ ATPase domain 516 - 656 IPR003593-2
domain ATPase, AAA-type, core 247 - 376 IPR003959-1
domain ATPase, AAA-type, core 520 - 654 IPR003959-2
conserved_site ATPase, AAA-type, conserved site 347 - 365 IPR003960-1
conserved_site ATPase, AAA-type, conserved site 624 - 642 IPR003960-2
domain CDC48, domain 2 131 - 197 IPR004201
domain Spastin/Vps4, C-terminal 732 - 771 IPR015415
domain AAA ATPase, AAA+ lid domain 399 - 440 IPR041569-1
domain AAA ATPase, AAA+ lid domain 676 - 715 IPR041569-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, perinuclear region
  • Cytoplasm
  • Colocalizes with ubxn-1, ubxn-2 and ubxn-3 to the perinuclear region in spermatocytes (PubMed:20977550)
  • Localizes to the perinuclear region in intestinal cells (PubMed:25721663)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
VCP-NPL4-UFD1 AAA ATPase complex A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
identical protein binding Binding to an identical protein or proteins.
polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination of the target protein.
protein-containing complex binding Binding to a macromolecular complex.

10 GO annotations of biological process

Name Definition
autophagosome maturation Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
ER-associated misfolded protein catabolic process The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
mitotic spindle disassembly The controlled breakdown of the spindle during a mitotic cell cycle.
positive regulation of mitotic cell cycle, embryonic Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
regulation of protein localization to chromatin Any process that modulates the frequency, rate or extent of protein localization to chromatin.
retrograde protein transport, ER to cytosol The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NB90 SPATA5 Ribosome biogenesis protein SPATA5 Homo sapiens (Human) PR
P55072 VCP Transitional endoplasmic reticulum ATPase Homo sapiens (Human) PR
Q01853 Vcp Transitional endoplasmic reticulum ATPase Mus musculus (Mouse) PR
P54812 cdc-48.2 Transitional endoplasmic reticulum ATPase homolog 2 Caenorhabditis elegans PR
10 20 30 40 50 60
MASVPTHQSE KEKKNDELST AILKDKVKPN RLIVDQSEQD DNSVIAVSQA KMDELGLFRG
70 80 90 100 110 120
DAVILKGKKR KESVAIIVSD ESCPNEKVRM NRVVRNNLRI RLGDVVSITP APNLSYGTRI
130 140 150 160 170 180
HVLPIDDTIE GLTGNLFDVF LKPYFLEAYR PLHKGDIFTV QAAMRTVEFK VVETEPAPAC
190 200 210 220 230 240
IVSPDTMIHY EGDPIKREEE EESMNDIGYD DLGGVRKQLA QIKEMVELPL RHPQLFKAIG
250 260 270 280 290 300
IKPPRGILLF GPPGTGKTLI ARAVANETGS FFFLINGPEV MSKMSGESES NLRKAFEECE
310 320 330 340 350 360
KNQPAILFID EIDAIAPKRE KTNGEVERRI VSQLLTLMDG VKGRSNLVVI AATNRPNSID
370 380 390 400 410 420
GALRRFGRFD REIDIGIPDA VGRLEILRIH TKNMKLADDV DLEQIANECH GFVGADLASL
430 440 450 460 470 480
CSEAALQQIR EKMELIDLED DQIDAEVLNS LAVTMENFRF AQGKSSPSAL REAVVETPNT
490 500 510 520 530 540
TWSDIGGLQN VKRELQELVQ YPVEHPEKYL KFGMQPSRGV LFYGPPGCGK TLLAKAIANE
550 560 570 580 590 600
CQANFISIKG PELLTMWFGE SEANVRDVFD KARAAAPCVL FFDELDSIAK ARGGGAGGDG
610 620 630 640 650 660
GGASDRVINQ VLTEMDGMNA KKNVFIIGAT NRPDIIDPAV LRPGRLDQLI YIPLPDEASR
670 680 690 700 710 720
HQILKASLRK TPLSKDLDLT FLAKNTVGFS GADLTEICQR ACKLAIRESI EKEIRIEKER
730 740 750 760 770 780
QDRQARGEEL MEDDAVDPVP EITRAHFEEA MKFARRSVTD NDIRKYEMFA QTLQQSRGFG
790 800
NNFKFPGEQR GSDAPSAPVP AQDDDDLYN