AiPD: Autoinhibited Protein Database

P54725

Gene name	RAD23A
Protein name	UV excision repair protein RAD23 homolog A
Names	HR23A, hHR23A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5886
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-339 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

49-339 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

17 structures for P54725

Entry ID	Method	Resolution	Chain	Position	Source
1DV0	NMR	-	A	319-363	PDB
1F4I	NMR	-	A	319-363	PDB
1IFY	NMR	-	A	156-204	PDB
1OQY	NMR	-	A	1-363	PDB
1P98	NMR	-	A	1-78	PDB
1P9D	NMR	-	U	1-78	PDB
1QZE	NMR	-	A	2-363	PDB
1TP4	NMR	-	A	223-317	PDB
2WYQ	X-ray	165 A	A	1-82	PDB
5XBO	NMR	-	B	156-204	PDB
6W2G	X-ray	110 A	A/B	155-204	PDB
6W2H	X-ray	160 A	A	155-204	PDB
6W2I	X-ray	145 A	A	155-204	PDB
6XQI	X-ray	234 A	F/G	319-358	PDB
6XQJ	NMR	-	A	223-363	PDB
7TGP	X-ray	140 A	A	155-204	PDB
AF-P54725-F1	Predicted				AlphaFoldDB

258 variants for P54725

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1411161505 CA404317709	2	A>S		No	ClinGen gnomAD
CA404317721 rs1426172837	4	T>A		No	ClinGen TOPMed
rs753433859 CA9236116	4	T>N		No	ClinGen ExAC TOPMed gnomAD
CA9236118 rs778413534	5	I>S		No	ClinGen ExAC gnomAD
CA9236117 rs756873359	5	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1312576686 CA404317746	8	K>R		No	ClinGen gnomAD
CA305523208 rs45546235	11	Q>*		No	ClinGen TOPMed gnomAD
CA9236119 rs745342405	13	Q>*		No	ClinGen ExAC gnomAD
rs1411756392 CA404317787	14	T>I		No	ClinGen gnomAD
CA9236120 rs769191860	15	F>L		No	ClinGen ExAC gnomAD
rs1234650768 CA404317798	16	K>Q		No	ClinGen TOPMed gnomAD
CA9236122 rs748569014	19	M>I		No	ClinGen ExAC gnomAD
CA404317819 rs1274910168	19	M>V		No	ClinGen gnomAD
rs770051390 CA9236123	20	E>D		No	ClinGen ExAC TOPMed gnomAD
CA9236124 rs773560731	21	P>A		No	ClinGen ExAC gnomAD
rs771137182 CA9236126	22	D>E		No	ClinGen ExAC gnomAD
CA9236127 rs774608082	23	E>Q		No	ClinGen ExAC gnomAD
CA305523308 rs759661066	24	T>K		No	ClinGen ExAC TOPMed gnomAD
CA9236128 rs759661066	24	T>M		No	ClinGen ExAC TOPMed gnomAD
CA404319572 rs1261308140	26	K>R		No	ClinGen gnomAD
rs756611226 CA9236163	27	V>A		No	ClinGen ExAC gnomAD
rs141708834 CA9236162	27	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA404319678 rs1415818834	30	E>D		No	ClinGen gnomAD
CA404319708 rs1474915283	32	I>T		No	ClinGen gnomAD
TCGA novel	32	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778316310 CA9236164	34	A>S		No	ClinGen ExAC gnomAD
rs749668247 CA9236165 COSM991547	38	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs749668247 CA9236166	38	R>G		No	ClinGen ExAC TOPMed gnomAD
CA404319859 rs1452100267	38	R>H		No	ClinGen TOPMed gnomAD
rs1288610281 CA404319947	42	P>S		No	ClinGen gnomAD
rs746097976 CA9236168	43	V>M		No	ClinGen ExAC gnomAD
CA404320358 CA9236175 rs146958349	58	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs761578570 CA9236174	58	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	59	V>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404320442 rs1484093479	62	R>M		No	ClinGen gnomAD
CA9236176 rs772935104	64	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs765976759 CA9236178	65	R>C		No	ClinGen ExAC TOPMed gnomAD
CA404320501 rs1182917616	66	I>V		No	ClinGen gnomAD
CA404320515 rs751071968	67	D>H		No	ClinGen ExAC gnomAD
CA9236179 rs751071968	67	D>N		No	ClinGen ExAC gnomAD
CA9236180 rs759068052	68	E>K		No	ClinGen ExAC gnomAD
TCGA novel	73	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754368275 CA9236182	74	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	78	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9236202 rs750863392	79	T>I		No	ClinGen ExAC gnomAD
rs199689360 CA9236204	82	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA404320800 rs1272107992	83	Q>P		No	ClinGen TOPMed
rs1384036048 CA404320817	84	G>A		No	ClinGen TOPMed
rs1384036048 CA404320815	84	G>D		No	ClinGen TOPMed
rs73505386 CA9236205	84	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1286422563 CA404320837	86	S>A		No	ClinGen TOPMed
CA9236206 rs538175343	88	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	89	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	90	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	91	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1340447793 CA404320902	91	A>S		No	ClinGen TOPMed
rs923397006 CA305525592	91	A>V		No	ClinGen gnomAD
rs781356707 CA9236207	93	P>R		No	ClinGen ExAC gnomAD
rs748188762 CA9236208	94	T>I		No	ClinGen ExAC gnomAD
rs1329620240 CA404320956	95	A>P		No	ClinGen TOPMed
CA305525611 rs908908485	96	A>T		No	ClinGen TOPMed gnomAD
rs1450454506 CA404320976	96	A>V		No	ClinGen TOPMed gnomAD
CA404320981 rs1416940431	97	P>A		No	ClinGen gnomAD
rs1168205750 CA404320990	97	P>L		No	ClinGen TOPMed
CA9236210 rs777666414	100	S>A		No	ClinGen ExAC TOPMed gnomAD
rs1164807985 CA404321054	102	S>F		No	ClinGen gnomAD
CA9236211 rs375981873	104	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs773952708 CA9236213	107	P>A		No	ClinGen ExAC TOPMed gnomAD
CA404321149 rs1437005388	109	S>L		No	ClinGen TOPMed gnomAD
rs771580434 CA9236215	110	G>S		No	ClinGen ExAC gnomAD
CA9236216 rs775176242	113	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1360056343 CA404321216	113	H>Y		No	ClinGen gnomAD
TCGA novel	115	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404321273 rs765900414	115	P>L		No	ClinGen ExAC gnomAD
CA9236218 rs765900414	115	P>R		No	ClinGen ExAC gnomAD
CA305525701 rs1006063317	115	P>S		No	ClinGen TOPMed gnomAD
CA9236221 rs766779899	118	A>T		No	ClinGen ExAC TOPMed gnomAD
rs751822670 CA9236222	119	R>T		No	ClinGen ExAC TOPMed gnomAD
rs1280661165 CA404321377	120	E>G		No	ClinGen TOPMed
rs1474855136 CA404321393	121	D>N		No	ClinGen gnomAD
CA9236224 rs767606169	122	K>N		No	ClinGen ExAC TOPMed gnomAD
CA9236225 rs752825559	123	S>I		No	ClinGen ExAC TOPMed gnomAD
rs1412540965 CA404321509	125	S>P		No	ClinGen gnomAD
rs777756589 CA9236227	129	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs749232374 CA9236228	130	P>S		No	ClinGen ExAC TOPMed gnomAD
VAR_016251 rs11558955 CA9236230	131	T>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA9236231 rs148187629	131	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9236232 rs148187629	131	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs558256837 CA9236234	132	T>K		No	ClinGen ExAC gnomAD
CA9236233 rs558256837	132	T>M		No	ClinGen ExAC gnomAD
rs776223624 CA9236236	134	P>L		No	ClinGen ExAC gnomAD
CA404321711 rs1282647501	135	E>G		No	ClinGen gnomAD
CA9236237 rs763537337	136	S>P		No	ClinGen ExAC TOPMed gnomAD
CA9236240 rs759798483	137	V>A		No	ClinGen ExAC TOPMed gnomAD
CA9236239 rs200107326	137	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9236238 rs200107326	137	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1381401815 CA404321772	138	S>L		No	ClinGen TOPMed
rs200506311 CA9236241	139	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1186528553 CA404321779	139	G>D		No	ClinGen gnomAD
CA404321849 rs1568453170	140	S>C		No	ClinGen Ensembl
CA404321857 rs1463931095	141	V>L		No	ClinGen TOPMed
rs1306029963 CA404321881	142	P>L		No	ClinGen gnomAD
CA9236257 rs760016308	143	S>P		No	ClinGen ExAC gnomAD
CA9236259 rs141369284	145	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9236260 rs369026746	147	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA9236262 rs753994476 CA9236263	148	G>R		No	ClinGen ExAC gnomAD
rs1055842383 CA305526093	149	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs765282021 CA9236264	149	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA404321966 rs201128109	152	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9236266 rs758351125	153	A>T		No	ClinGen ExAC TOPMed gnomAD
rs376900039 CA9236267	153	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA9236269 rs200238909	154	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780970129 CA9236270	155	S>F		No	ClinGen ExAC TOPMed gnomAD
CA305526165 rs1030984404	156	T>K		No	ClinGen gnomAD
rs1030984404 CA404322086	156	T>M		No	ClinGen gnomAD
rs1030984404 CA404322085	156	T>R		No	ClinGen gnomAD
rs150788485 CA9236291	159	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1160441898 CA404322236	161	S>F		No	ClinGen gnomAD
rs748795390 CA9236293	165	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9236295 rs780521795	166	M>V		No	ClinGen ExAC TOPMed gnomAD
rs538880947 CA9236296	168	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA404322357 rs1309037665	171	M>I		No	ClinGen gnomAD
rs547432572 CA9236298	171	M>T		No	ClinGen 1000Genomes ExAC gnomAD
CA404322350 rs1354230142	171	M>V		No	ClinGen TOPMed gnomAD
CA404322364 rs1314975685	173	M>V		No	ClinGen gnomAD
rs1256385036 CA404322377	174	G>A		No	ClinGen gnomAD
rs1237972905 CA404322373	174	G>S		No	ClinGen gnomAD
rs778646826 CA305526468	176	E>K		No	ClinGen Ensembl
rs1348809848 CA404322395	177	R>*		No	ClinGen gnomAD
CA9236300 rs200493290	177	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs565619875 CA9236302	178	E>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9236303 rs565619875	178	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
VAR_020377 rs4987203 CA9236305	179	R>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA9236304 rs774428190	179	R>W		No	ClinGen ExAC TOPMed gnomAD
CA404322407 rs1417722670	180	V>I		No	ClinGen gnomAD
CA9236307 rs554597904	181	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9236308 rs755757631	182	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	183	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404322453 rs1568453423	187	S>R		No	ClinGen Ensembl
rs756752141 CA9236311	187	S>T		No	ClinGen ExAC
rs778325372 CA9236312	190	N>T		No	ClinGen ExAC gnomAD
rs1371016644 CA404322486	192	H>P		No	ClinGen TOPMed gnomAD
rs747524787 COSM1711887 CA9236313	193	R>*	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs755462298 CA9236314	193	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA404322498 rs1372869284	194	A>G		No	ClinGen gnomAD
CA404322499 COSM233228 rs1372869284	194	A>V	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
CA404322503 rs1268388032	195	V>A		No	ClinGen TOPMed
rs748513382 CA9236316	195	V>M		No	ClinGen ExAC TOPMed gnomAD
CA305527961 rs769180661	198	L>V		No	ClinGen TOPMed gnomAD
VAR_016252 CA9236317 rs4987202	200	T>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA404322562 rs1218017273	203	P>S		No	ClinGen TOPMed gnomAD
CA9236343 rs779167454	204	G>V		No	ClinGen ExAC
CA404322574 rs1225395350	205	S>N		No	ClinGen gnomAD
rs139644856 CA9236344	206	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA305528200 rs977516182	207	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA305528202 rs924695646	208	P>L		No	ClinGen TOPMed gnomAD
CA305528208 rs868641497	209	E>K		No	ClinGen gnomAD
CA404322596 rs868641497	209	E>Q		No	ClinGen gnomAD
CA9236349 rs776358401	211	G>D		No	ClinGen ExAC gnomAD
rs768506976 CA9236348	211	G>S		No	ClinGen ExAC TOPMed gnomAD
CA9236350 rs761483338	212	S>F		No	ClinGen ExAC gnomAD
CA404322654 rs1205455830	217	Q>R		No	ClinGen TOPMed
rs531597926 CA9236353	219	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9236352 rs542397046	219	S>P		No	ClinGen ExAC TOPMed gnomAD
rs756523126 CA9236356	220	E>A		No	ClinGen ExAC gnomAD
rs756523126 CA404322671	220	E>G		No	ClinGen ExAC gnomAD
CA9236358 COSM1390693 rs778306837	222	P>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA9236357 rs778306837	222	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1357601475 CA404322685	222	P>S		No	ClinGen TOPMed
TCGA novel	223	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404322692 rs1313514139	223	A>V		No	ClinGen gnomAD
rs148708384 CA9236361	224	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA305528366 rs11558954	227	A>V		No	ClinGen Ensembl
rs1163586176 CA404322742	229	E>A		No	ClinGen gnomAD
CA404322743 rs1366709657	229	E>D		No	ClinGen gnomAD
rs1237392203 CA404322749	230	N>S		No	ClinGen gnomAD
rs1237392203 CA404322748	230	N>T		No	ClinGen gnomAD
CA305528368 rs922436091	231	P>T		No	ClinGen gnomAD
TCGA novel	232	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs41561218 CA305528376	233	E>*		No	ClinGen Ensembl
rs1229162656 CA404322779	235	L>V		No	ClinGen Ensembl
CA9236386 rs754956151	236	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9236385 rs747026594	236	R>W		No	ClinGen ExAC TOPMed gnomAD
rs910578874 CA305528408	237	D>H		No	ClinGen Ensembl
CA9236387 rs781094089	237	D>V		No	ClinGen ExAC gnomAD
rs1400116042 CA404322809	240	Q>P		No	ClinGen gnomAD
CA9236389 rs769581525	243	N>I		No	ClinGen ExAC TOPMed gnomAD
CA9236390 rs772826183	244	M>T		No	ClinGen ExAC TOPMed gnomAD
rs201928561 CA9236392	245	R>L		No	ClinGen ExAC TOPMed gnomAD
rs201928561 CA9236393	245	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA404322846 rs1270308155	245	R>W		No	ClinGen gnomAD
rs1599668535 CA404322861	247	V>G		No	ClinGen Ensembl
rs1219918662 CA404322857	247	V>L		No	ClinGen TOPMed
rs547674173 CA9236395	249	Q>E		No	ClinGen 1000Genomes ExAC gnomAD
rs267605293 CA305528472	252	P>S		No	ClinGen Ensembl
rs777277641 CA404322902	253	A>G		No	ClinGen ExAC TOPMed gnomAD
rs777277641 CA9236397	253	A>V		No	ClinGen ExAC TOPMed gnomAD
CA9236400 rs750711569	257	A>T		No	ClinGen ExAC TOPMed gnomAD
rs758684522 CA9236401	260	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	261	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs2242518 CA305528492	261	Q>R		No	ClinGen Ensembl
rs766487138 CA9236402	264	Q>K		No	ClinGen ExAC gnomAD
TCGA novel	264	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404323000 rs1462311750	269	L>H		No	ClinGen gnomAD
CA404323008 rs1167495427	270	L>F		No	ClinGen gnomAD
TCGA novel	271	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305531337 rs151314000	273	I>V		No	ClinGen ESP TOPMed
CA9236425 rs760520920	275	R>L		No	ClinGen ExAC gnomAD
CA9236424 rs760520920	275	R>Q		No	ClinGen ExAC gnomAD
CA305531342 rs1046715911	275	R>W		No	ClinGen TOPMed gnomAD
CA305531388 rs1050265071	277	Q>*		No	ClinGen Ensembl
CA305531398 rs902501491	278	E>G		No	ClinGen TOPMed
rs778878178 CA9236428	278	E>Q		No	ClinGen ExAC gnomAD
CA9236429 rs752902956	284	L>V		No	ClinGen ExAC gnomAD
rs778120001 CA9236431	287	P>R		No	ClinGen ExAC gnomAD
CA9236432 rs747360004	288	P>L		No	ClinGen ExAC gnomAD
CA9236434 rs771465178	290	E>G		No	ClinGen ExAC gnomAD
rs1344742558 CA404323158	291	L>V		No	ClinGen gnomAD
rs781751879 CA9236435	292	A>V		No	ClinGen ExAC TOPMed gnomAD
rs887596156 CA305531492	293	D>Y		No	ClinGen Ensembl
rs773739832 CA9236440	296	D>V		No	ClinGen ExAC gnomAD
CA9236441 rs761453504	297	V>A		No	ClinGen ExAC gnomAD
rs1053804917 CA305531552	299	G>E		No	ClinGen TOPMed
rs772899507 CA9236443	299	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	301	V>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9236446 rs753723172	303	A>T		No	ClinGen ExAC TOPMed gnomAD
CA305531590 rs1018065445	304	I>T		No	ClinGen TOPMed gnomAD
rs1599671529 CA404323237	304	I>V		No	ClinGen Ensembl
rs1213042423 CA404323245	305	G>E		No	ClinGen gnomAD
CA404323259 rs1401343234	307	E>A		No	ClinGen TOPMed
CA404323275 rs1483231608	309	P>L		No	ClinGen gnomAD
rs752710312 CA9236449	311	M>I		No	ClinGen ExAC
CA404323308 rs758558966	314	I>F		No	ClinGen ExAC gnomAD
CA9236450 rs758558966	314	I>L		No	ClinGen ExAC gnomAD
rs758558966 CA9236451	314	I>V		No	ClinGen ExAC gnomAD
TCGA novel	317	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751865333 CA9236452	317	T>M		No	ClinGen ExAC TOPMed gnomAD
CA404323332 rs781702169	318	P>A		No	ClinGen ExAC gnomAD
CA9236455 rs746311517	318	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9236454 rs781702169	318	P>T		No	ClinGen ExAC gnomAD
CA404323339 rs1568455387	319	Q>P		No	ClinGen Ensembl
TCGA novel CA9236459 rs747588545	320	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC TOPMed gnomAD NCI-TCGA
rs772809602 CA9236460	322	E>A		No	ClinGen ExAC gnomAD
TCGA novel	322	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	323	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	325	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776319080 CA9236485	329	A>T		No	ClinGen ExAC gnomAD
CA404323468 rs1187715755	336	L>V		No	ClinGen gnomAD
rs916747485 CA305531830	340	A>V		No	ClinGen TOPMed
rs762963923 CA9236489	343	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	347	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	349	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404323601 rs767826146	354	F>L		No	ClinGen ExAC gnomAD
rs1399995264 CA404323613	357	S>G		No	ClinGen gnomAD
rs775051740 CA305531878	357	S>N		No	ClinGen Ensembl
rs756392712 CA404323658	362	D>E		No	ClinGen ExAC TOPMed gnomAD
CA9236496 rs766788097	363	E>K		No	ClinGen ExAC gnomAD
CA404323660 rs766788097	363	E>Q		No	ClinGen ExAC gnomAD

No associated diseases with P54725

1 regional properties for P54725

Type	Name	Position	InterPro Accession
domain	Small GTP-binding protein domain	7 - 162	IPR005225

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome complex	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

7 GO annotations of molecular function

Name	Definition
damaged DNA binding	Binding to damaged DNA.
kinase binding	Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
polyubiquitin modification-dependent protein binding	Binding to a protein upon poly-ubiquitination of the target protein.
proteasome binding	Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
single-stranded DNA binding	Binding to single-stranded DNA.
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
ubiquitin-specific protease binding	Binding to a ubiquitin-specific protease.

7 GO annotations of biological process

Name	Definition
nucleotide-excision repair	A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
positive regulation of cell cycle	Any process that activates or increases the rate or extent of progression through the cell cycle.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
positive regulation of viral genome replication	Any process that activates or increases the frequency, rate or extent of viral genome replication.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein destabilization	Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
regulation of proteasomal ubiquitin-dependent protein catabolic process	Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32628	RAD23	UV excision repair protein RAD23	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
A3KMV2	RAD23A	UV excision repair protein RAD23 homolog A	Bos taurus (Bovine)	PR
P54726	Rad23a	UV excision repair protein RAD23 homolog A	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAVTITLKTL	QQQTFKIRME	PDETVKVLKE	KIEAEKGRDA	FPVAGQKLIY	AGKILSDDVP
70	80	90	100	110	120
IRDYRIDEKN	FVVVMVTKTK	AGQGTSAPPE	ASPTAAPESS	TSFPPAPTSG	MSHPPPAARE
130	140	150	160	170	180
DKSPSEESAP	TTSPESVSGS	VPSSGSSGRE	EDAASTLVTG	SEYETMLTEI	MSMGYERERV
190	200	210	220	230	240
VAALRASYNN	PHRAVEYLLT	GIPGSPEPEH	GSVQESQVSE	QPATEAAGEN	PLEFLRDQPQ
250	260	270	280	290	300
FQNMRQVIQQ	NPALLPALLQ	QLGQENPQLL	QQISRHQEQF	IQMLNEPPGE	LADISDVEGE
310	320	330	340	350	360
VGAIGEEAPQ	MNYIQVTPQE	KEAIERLKAL	GFPESLVIQA	YFACEKNENL	AANFLLSQNF

DDE