P53917

PR
Gene name
FAR11 (YNL127W, N1221, N1875)
Protein name
Factor arrest protein 11
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YNL127W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-236 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P53917

Entry ID Method Resolution Chain Position Source
AF-P53917-F1 Predicted AlphaFoldDB

15 variants for P53917

Variant ID(s) Position Change Description Diseaes Association Provenance
s14-384022 12 P>S No SGRP
s14-384104 39 T>I No SGRP
s14-384103 39 T>P No SGRP
s14-384243 85 I>M No SGRP
s14-384244 86 S>R No SGRP
s14-384352 122 G>S No SGRP
s14-384509 174 G>D No SGRP
s14-384994 336 I>V No SGRP
s14-385523 512 I>N No SGRP
s14-385704 572 L>F No SGRP
s14-385810 608 L>F No SGRP
s14-385906 640 A>T No SGRP
s14-386231 748 R>L No SGRP
s14-386249 754 A>V No SGRP
s14-386542 852 H>D No SGRP

No associated diseases with P53917

2 regional properties for P53917

Type Name Position InterPro Accession
domain Far11/STRP, N-terminal 217 - 488 IPR012486
domain Far11/STRP, C-terminal 585 - 950 IPR021819

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
FAR/SIN/STRIPAK complex A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body.
Golgi trans cisterna The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name Definition
cellular response to pheromone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.
cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
mitotic intra-S DNA damage checkpoint signaling A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
positive regulation of macroautophagy Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
re-entry into mitotic cell cycle after pheromone arrest The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0P5J8 STRIP1 Striatin-interacting protein 1 Bos taurus (Bovine) PR
Q9ULQ0 STRIP2 Striatin-interacting protein 2 Homo sapiens (Human) PR
Q5VSL9 STRIP1 Striatin-interacting protein 1 Homo sapiens (Human) PR
Q8C9H6 Strip2 Striatin-interacting proteins 2 Mus musculus (Mouse) PR
Q8C079 Strip1 Striatin-interacting protein 1 Mus musculus (Mouse) PR
Q803T2 strip1 Striatin-interacting protein 1 homolog Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MNASGRSHSK GPIIRSVSLE DLKRNSSFKG NLKYKDEVTS HKEPQVGTLS NEELLKDLDN
70 80 90 100 110 120
MLRGKLNMGR NSFHADKRNK SDGNISALTF KARSGLEGDI RTIDIQQDSS DENDNFKFSD
130 140 150 160 170 180
DGVNKDRNNE KDNNTDNAVE FQDDAEEAEE ENEDESFANV DELDGFDLNK VSDGKHVPIN
190 200 210 220 230 240
EKGEVDYNMP VDKEFQKSLD QCAASLEERS SAPYALQRAV DWELKMFYSL EDELSEWFCS
250 260 270 280 290 300
SDYMHFGQTQ TLFKQKITQP QLFFDDENYA ASVVECLIED IPNSLASNLL ALSYISMGCF
310 320 330 340 350 360
AFTNSKSEHT KIIRRNNLML VPHIQEIVHA FKKIAISCRD DNRNLKKQTI LLFHSSTILY
370 380 390 400 410 420
FICSICIEGR GENPEAVNVV IDAFEKTDLL EFLTKYIENW RWNSRLAMRI RNMISLLFKL
430 440 450 460 470 480
IVLQFGDSSV YKQTKSSIYN LHGLTYPSKH PEKLSISPLH YQAFREDITS RFPDYNMPSS
490 500 510 520 530 540
GLPKDVDKSE SLSQFLEIPR PKSKNPLNMA LIVPEKHIAT PAPSPPSSPQ LMHLGEGPRP
550 560 570 580 590 600
RKSFQTNMAY PCLYPSDNEG SEDDTLEDRI DLNIERKPDN DIVIPFSTEE AARILSESLE
610 620 630 640 650 660
IKLSTKQLWY ERDLFMITER GWKQQLENEP YDYAALNHDA NSSKEEKSAI CIMQRIDKYY
670 680 690 700 710 720
KSCLSSFNSL VFVLLQTMES SLTNNFHRKS EVSDKNLLNM LTPQLEIVRA KELSLKSAAG
730 740 750 760 770 780
ILHALLKWFK LSHILKFEHL AVVIHDSRYI NTCASILSKY SEVYPERVFN KYVQTPNSFW
790 800 810 820 830 840
KECSLSNESY RESYSVDDSG EVDTEIMPSF AYLLRILRKV TGNKTQRLKE LPLSIGILFK
850 860 870 880 890 900
RYYRLFNLDM YHPILKITRE LTPFKNKRWK SEHMELISGV YLYEKLELTD NWVTGKDISG
910 920 930 940 950
ELSDACGQEI ALRALLQFYN FQHYEISMED LGYGHRNSSS QDLLNKESEY LNI