P52020

PR
Gene name
Sqle (Erg1)
Protein name
Squalene monooxygenase
Names
Squalene epoxidase, SE
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:29230
EC number
1.14.14.17: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

66-138 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P52020

Entry ID Method Resolution Chain Position Source
AF-P52020-F1 Predicted AlphaFoldDB

No variants for P52020

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P52020

No associated diseases with P52020

8 regional properties for P52020

Type Name Position InterPro Accession
domain RNA recognition motif domain 4 - 72 IPR000504-1
domain RNA recognition motif domain 155 - 230 IPR000504-2
domain RNA recognition motif domain 284 - 360 IPR000504-3
domain RNA recognition motif domain 400 - 477 IPR000504-4
domain RNA recognition motif domain 925 - 1001 IPR000504-5
domain RBM12B, RNA recognition motif 2 153 - 238 IPR034588
domain RBM12B, RNA recognition motif 3 284 - 363 IPR034858
domain RNA-binding protein 12B, RNA recognition motif 4 400 - 475 IPR047188

Functions

Description
EC Number 1.14.14.17 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Microsome membrane ; Peripheral membrane protein
  • Endoplasmic reticulum membrane; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

2 GO annotations of molecular function

Name Definition
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
squalene monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).

6 GO annotations of biological process

Name Definition
cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
cholesterol metabolic process The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
lipid droplet formation A process that results in the assembly, arrangement of constituent parts of a lipid droplet.
regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation.
response to organic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32476 ERG1 Squalene epoxidase ERG1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q14534 SQLE Squalene monooxygenase Homo sapiens (Human) PR
P52019 Sqle Squalene monooxygenase Mus musculus (Mouse) PR
10 20 30 40 50 60
MWTFLGIATF TYFYKKCGDV TLANKELLLC VLVFLSLGLV LSYRCRHRNG GLLGRHQSGS
70 80 90 100 110 120
QFAAFSDILS ALPLIGFFWA KSPPESEKKE QLESKRRRKE VNLSETTLTG AATSVSTSSV
130 140 150 160 170 180
TDPEVIIIGS GVLGSALATV LSRDGRTVTV IERDLKEPDR ILGECLQPGG YRVLRELGLG
190 200 210 220 230 240
DTVESLNAHH IHGYVIHDCE SRSEVQIPYP VSENNQVQSG VAFHHGKFIM SLRKAAMAEP
250 260 270 280 290 300
NVKFIEGVVL RLLEEDDAVI GVQYKDKETG DTKELHAPLT VVADGLFSKF RKNLISNKVS
310 320 330 340 350 360
VSSHFVGFIM KDAPQFKANF AELVLVDPSP VLIYQISPSE TRVLVDIRGE LPRNLREYMT
370 380 390 400 410 420
EQIYPQIPDH LKESFLEACQ NARLRTMPAS FLPPSSVNKR GVLLLGDAYN LRHPLTGGGM
430 440 450 460 470 480
TVALKDIKIW RQLLKDIPDL YDDAAIFQAK KSFFWSRKRS HSFVVNVLAQ ALYELFSATD
490 500 510 520 530 540
DSLRQLRKAC FLYFKLGGEC LTGPVGLLSI LSPDPLLLIR HFFSVAVYAT YFCFKSEPWA
550 560 570
TKPRALFSSG AILYKACSII FPLIYSEMKY LVH