AiPD: Autoinhibited Protein Database

Gene name	Sqle (Erg1)
Protein name	Squalene monooxygenase
Names	Squalene epoxidase, SE
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:20775
EC number	1.14.14.17: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

58-143 (Predicted disordered autoinhibitory region) PR

58-143 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P52019-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389357052	98	K>I	No	EVA
rs3406498403	136	L>*	No	EVA
rs3406265804	136	L>M	No	EVA
rs3389341904	138	A>E	No	EVA
rs3389352254	159	R>M	No	EVA
rs3389341898	204	V>F	No	EVA
rs248093556	218	S>N	No	EVA
rs3389333030	248	V>M	No	EVA
rs3404627817	278	L>Q	No	EVA
rs3389282376	317	P>H	No	EVA
rs3389341879	319	F>S	No	EVA
rs226152384	328	S>N	No	EVA
rs3389372040	344	V>I	No	EVA
rs251110350	361	Q>H	No	EVA
rs3389333075	362	I>F	No	EVA
rs246896570	381	G>C	No	EVA
rs260154688	397	N>S	No	EVA
rs3406498451	399	R>G	No	EVA
rs3389355900	436	I>T	No	EVA
rs3389282382	438	D>H	No	EVA
rs3389352264	458	R>K	No	EVA
rs3389371978	518	I>N	No	EVA
rs3389333062	526	I>N	No	EVA
rs3389363251	542	P>S	No	EVA
rs251691253	559	L>I	No	EVA

Type	Name	Position	InterPro Accession
domain	Squalene epoxidase	275 - 546	IPR013698

		Description
EC Number	1.14.14.17	With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization	Microsome membrane ; Peripheral membrane protein Endoplasmic reticulum membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

Name	Definition
FAD binding	Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
squalene monooxygenase activity	Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).

Name	Definition
cellular aromatic compound metabolic process	The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
cholesterol metabolic process	The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
lipid droplet formation	A process that results in the assembly, arrangement of constituent parts of a lipid droplet.
regulation of cell population proliferation	Any process that modulates the frequency, rate or extent of cell proliferation.
response to organic substance	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
sterol biosynthetic process	The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32476	ERG1	Squalene epoxidase ERG1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q14534	SQLE	Squalene monooxygenase	Homo sapiens (Human)	PR
P52020	Sqle	Squalene monooxygenase	Rattus norvegicus (Rat)	PR