P32476
Gene name |
ERG1 |
Protein name |
Squalene epoxidase ERG1 |
Names |
SE, Ergosterol biosynthetic protein 1, Squalene monooxygenase ERG1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR175C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P32476
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P32476-F1 | Predicted | AlphaFoldDB |
7 variants for P32476
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-847926 | 168 | T>I | No | SGRP | |
| s07-847759 | 224 | V>F | No | SGRP | |
| s07-847732 | 233 | G>C | No | SGRP | |
| 251 | L>F | strain: A2-M8; confers resistance to the allylamine antifungal terbinafine [UniProt] | No | ||
| s07-847635 | 265 | P>R | No | SGRP | |
| s07-847354 | 359 | I>V | No | SGRP | |
| s07-847307 | 374 | L>F | No | SGRP |
No associated diseases with P32476
1 regional properties for P32476
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | SsrA-binding protein, conserved site | 30 - 42 | IPR020081 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| squalene monooxygenase activity | Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| ergosterol biosynthetic process | The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. |
| sterol biosynthetic process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAVNVAPEL | INADNTITYD | AIVIGAGVIG | PCVATGLARK | GKKVLIVERD | WAMPDRIVGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LMQPGGVRAL | RSLGMIQSIN | NIEAYPVTGY | TVFFNGEQVD | IPYPYKADIP | KVEKLKDLVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DGNDKVLEDS | TIHIKDYEDD | ERERGVAFVH | GRFLNNLRNI | TAQEPNVTRV | QGNCIEILKD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EKNEVVGAKV | DIDGRGKVEF | KAHLTFICDG | IFSRFRKELH | PDHVPTVGSS | FVGMSLFNAK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NPAPMHGHVI | LGSDHMPILV | YQISPEETRI | LCAYNSPKVP | ADIKSWMIKD | VQPFIPKSLR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSFDEAVSQG | KFRAMPNSYL | PARQNDVTGM | CVIGDALNMR | HPLTGGGMTV | GLHDVVLLIK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KIGDLDFSDR | EKVLDELLDY | HFERKSYDSV | INVLSVALYS | LFAADSDNLK | ALQKGCFKYF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QRGGDCVNKP | VEFLSGVLPK | PLQLTRVFFA | VAFYTIYLNM | EERGFLGLPM | ALLEGIMILI |
| 490 | |||||
| TAIRVFTPFL | FGELIG |