P51979
PR
Gene name |
HFM1 (MER3, YGL251C, NRE1046) |
Protein name |
ATP-dependent DNA helicase MER3 |
Names |
Protein HFM1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGL251C |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51979
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51979-F1 | Predicted | AlphaFoldDB |
23 variants for P51979
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-31372 | 38 | R>P | No | SGRP | |
| s07-31305 | 60 | E>D | No | SGRP | |
| s07-30161 | 442 | A>S | No | SGRP | |
| s07-30029 | 486 | V>I | No | SGRP | |
| s07-29522 | 655 | S>T | No | SGRP | |
| s07-29465 | 674 | I>V | No | SGRP | |
| s07-29398 | 696 | R>K | No | SGRP | |
| s07-29287 | 733 | L>P | No | SGRP | |
| s07-29227 | 753 | S>N | No | SGRP | |
| s07-29049 | 812 | Q>H | No | SGRP | |
| s07-28932 | 851 | E>D | No | SGRP | |
| s07-28799 | 896 | V>L | No | SGRP | |
| s07-28634 | 951 | N>H | No | SGRP | |
| s07-28345 | 1047 | T>M | No | SGRP | |
| s07-28288 | 1066 | K>R | No | SGRP | |
| s07-28256 | 1077 | P>S | No | SGRP | |
| s07-28204 | 1094 | H>R | No | SGRP | |
| s07-28187 | 1100 | N>D | No | SGRP | |
| s07-28127 | 1120 | P>S | No | SGRP | |
| s07-28114 | 1124 | Y>C | No | SGRP | |
| s07-28100 | 1129 | Q>K | No | SGRP | |
| s07-28096 | 1130 | M>T | No | SGRP | |
| s07-28081 | 1135 | A>V | No | SGRP |
No associated diseases with P51979
No regional properties for P51979
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P51979 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| heteroduplex DNA loop binding | Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration. |
| metal ion binding | Binding to a metal ion. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA unwinding involved in DNA replication | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
| homologous chromosome pairing at meiosis | The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| protein localization to site of double-strand break | Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred. |
| reciprocal meiotic recombination | The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. |
| resolution of meiotic recombination intermediates | The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKTKFDRLGT | GKRSRPSPNN | IDFNDQSATF | KRNKKNSRQP | SFKVGLSYNS | LLDDCDDENE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TEEIFEGRGL | QFFDKDDNFS | ITADDTQVTS | KLFDHDLEQT | PDEEAKKPKK | VTIRKSAKKC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSTTILPDSF | RGVFKFTEFN | KMQSEAFPSI | YESNENCIIS | SPTGSGKTVL | FELAILRLIK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ETNSDTNNTK | IIYIAPTKSL | CYEMYKNWFP | SFVNLSVGML | TSDTSFLETE | KAKKCNIIIT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TPEKWDLLTR | RWSDYSRLFE | LVKLVLVDEI | HTIKEKRGAS | LEVILTRMNT | MCQNIRFVAL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SATVPNIEDL | ALWLKTNNEL | PANILSFDES | YRQVQLTKFV | YGYSFNCKND | FQKDAIYNSK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LIEIIEKHAD | NRPVLIFCPT | RASTISTAKF | LLNNHIFSKS | KKRCNHNPSD | KILNECMQQG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IAFHHAGISL | EDRTAVEKEF | LAGSINILCS | TSTLAVGVNL | PAYLVIIKGT | KSWNSSEIQE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YSDLDVLQMI | GRAGRPQFET | HGCAVIMTDS | KMKQTYENLI | HGTDVLESSL | HLNLIEHLAA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ETSLETVYSI | ETAVNWLRNT | FFYVRFGKNP | AAYQEVNRYV | SFHSVEDSQI | NQFCQYLLDT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LVKVKIIDIS | NGEYKSTAYG | NAMTRHYISF | ESMKQFINAK | KFLSLQGILN | LLATSEEFSV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MRVRHNEKKL | FKEINLSPLL | KYPFLTEKKQ | SQIIDRVSQK | VSLLIQYELG | GLEFPSYEGA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SKLHQTLVQD | KFLVFRHCFR | LLKCMVDTFI | EKSDGTSLKN | TLFLLRSLNG | HCWENTPMVL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RQLKTIGLVS | VRRLIRHGIT | NLEEMGHLSD | TQIEYYLNLK | IGNGIKIKND | ISLLPCLNIR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TKLENCKIEN | EELWLTFKVE | ISATFKSSIW | HGQHLSLDIE | TEKSSGELID | FRRLQVNKLQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SPRGFRISAK | ISPKLEKIEF | SIHCQEIAGL | GKTIVYSTDH | LASQFSAKTP | NIRKDLNSLE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KCLFYESSSD | GEVGKTSRVS | HKDGLEESLS | SDDSILDYLN | ERKKSSKAVE | SAAVIHPEAH |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SSSHFSNGRQ | VRSNGNYECF | HSCKDKTQCR | HLCCKEGIPV | KYIKEKGPSS | IKPVSKPDQI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RQPLLAKNIN | TTPHLEKRLN | SKPKQWQEEN | TDIATVHTLP | SKIYNLSQQM | SSMEAGEQVL |
| 1150 | 1160 | 1170 | 1180 | ||
| KSGPENCPEI | IPIDLESSDS | YSSNTAASSI | SDPNGDLDFL | GSDIEFE |