P51566

PR
Gene name
AFC1 (AME2, At3g53570, F4P12_270)
Protein name
Serine/threonine-protein kinase AFC1
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G53570
EC number
2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

284-304 (Activation loop from InterPro)

Target domain

115-443 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P51566

Entry ID Method Resolution Chain Position Source
AF-P51566-F1 Predicted AlphaFoldDB

14 variants for P51566

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06308854 12 S>L No 1000Genomes
ENSVATH06308852 17 L>F No 1000Genomes
tmp_3_19864058_A_C 23 V>G No 1000Genomes
ENSVATH02500582 25 F>L No 1000Genomes
tmp_3_19863992_G_A 45 A>V No 1000Genomes
ENSVATH02500581 55 P>H No 1000Genomes
ENSVATH06308842 70 S>N No 1000Genomes
tmp_3_19863764_C_T 71 G>S No 1000Genomes
ENSVATH06308841 74 P>S No 1000Genomes
ENSVATH00417650 82 F>L No 1000Genomes
ENSVATH12745389 162 V>A No 1000Genomes
tmp_3_19863229_C_A 173 G>C No 1000Genomes
ENSVATH06308821 381 D>A No 1000Genomes
ENSVATH12745385 449 Q>H No 1000Genomes

No associated diseases with P51566

2 regional properties for P51566

Type Name Position InterPro Accession
domain Protein kinase domain 115 - 443 IPR000719
active_site Serine/threonine-protein kinase, active site 236 - 248 IPR008271

Functions

Description
EC Number 2.7.12.1 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

2 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P49761 CLK3 Dual specificity protein kinase CLK3 Homo sapiens (Human) PR
P49760 CLK2 Dual specificity protein kinase CLK2 Homo sapiens (Human) PR
10 20 30 40 50 60
MQSSVYRDKA SSIAMILETQ RNVEFPHRIV DKRPRKRPRL TWDAAPPLLP PPPPPTVFQP
70 80 90 100 110 120
PLYYGPEFAS GLVPNFVYPN MFYNGLPRQG SPPWRPDDKD GHYVFVVGDT LTPRYQILSK
130 140 150 160 170 180
MGEGTFGQVL ECFDNKNKEV VAIKVIRSIN KYREAAMIEI DVLQRLTRHD VGGSRCVQIR
190 200 210 220 230 240
NWFDYRNHIC IVFEKLGPSL YDFLRKNSYR SFPIDLVREL GRQLLESVAY MHDLRLIHTD
250 260 270 280 290 300
LKPENILLVS SEYIKIPDYK FLSRPTKDGS YFKNLPKSSA IKLIDFGSTT FEHQDHNYIV
310 320 330 340 350 360
STRHYRAPEV ILGVGWNYPC DLWSIGCILV ELCSGEALFQ THENLEHLAM MERVLGPLPP
370 380 390 400 410 420
HMVLRADRRS EKYFRRGAKL DWPEGATSRD SLKAVWKLPR LPNLIMQHVD HSAGDLIDLL
430 440 450 460
QGLLRYDPTE RFKAREALNH PFFTRSREQS IPPFNPNPHP FLYNQKN