AiPD: Autoinhibited Protein Database

Gene name	CLK3
Protein name	Dual specificity protein kinase CLK3
Names	CDC-like kinase 3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1198
EC number	2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

127-310 (Predicted disordered autoinhibitory region) PR

127-310 (Predicted disordered autoinhibitory region)

cis-regPred

Entry ID	Method	Resolution	Chain	Position	Source
2EU9	X-ray	153 A	A	284-638	PDB
2EXE	X-ray	235 A	A	275-631	PDB
2WU6	X-ray	192 A	A	275-632	PDB
2WU7	X-ray	225 A	A	275-632	PDB
3RAW	X-ray	209 A	A/B	275-632	PDB
6FT7	X-ray	202 A	A/B	275-632	PDB
6FYP	X-ray	229 A	A	275-632	PDB
6FYR	X-ray	142 A	A	275-632	PDB
6KHF	X-ray	260 A	A	149-638	PDB
6RCT	X-ray	232 A	A/B	275-632	PDB
6YTW	X-ray	200 A	A/B	275-632	PDB
6YTY	X-ray	176 A	A	275-632	PDB
6YU1	X-ray	190 A	a/c	275-632	PDB
6Z2V	X-ray	260 A	A	275-632	PDB
6Z51	X-ray	192 A	A	275-632	PDB
6Z52	X-ray	212 A	A/B	275-632	PDB
6Z53	X-ray	165 A	A	275-632	PDB
6Z54	X-ray	173 A	A	275-632	PDB
6Z55	X-ray	170 A	A/B	275-632	PDB
AF-P49761-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
VAR_040413 rs975796055	486	R>C	No	UniProt dbSNP
VAR_045579 rs910378995	607	Q>R	No	UniProt dbSNP
rs920443187 VAR_045580	628	R>W	No	UniProt dbSNP

Type	Name	Position	InterPro Accession
domain	GPCR, rhodopsin-like, 7TM	22 - 605	IPR017452

		Description
EC Number	2.7.12.1	Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization	[Isoform 1]: Nucleus Cytoplasm Cytoplasmic vesicle, secretory vesicle, acrosome ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
acrosomal vesicle	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
intermediate filament cytoskeleton	Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
RNA binding	Binding to an RNA molecule or a portion thereof.

Name	Definition
peptidyl-tyrosine phosphorylation	The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of RNA splicing	Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P49760	CLK2	Dual specificity protein kinase CLK2	Homo sapiens (Human)	PR
P51566	AFC1	Serine/threonine-protein kinase AFC1	Arabidopsis thaliana (Mouse-ear cress)	PR