AiPD: Autoinhibited Protein Database

P49760

Gene name	CLK2
Protein name	Dual specificity protein kinase CLK2
Names	CDC-like kinase 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1196
EC number	2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-139 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-139 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

326-346 (Activation loop from InterPro)

Target domain	163-479 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for P49760

Entry ID	Method	Resolution	Chain	Position	Source
3NR9	X-ray	289 A	A/B/C	135-496	PDB
5UNP	X-ray	292 A	A/B	129-496	PDB
6FYI	X-ray	260 A	A	132-496	PDB
6FYK	X-ray	239 A	A/B/C	136-496	PDB
6FYL	X-ray	195 A	A	136-496	PDB
6KHE	X-ray	280 A	A	1-499	PDB
AF-P49760-F1	Predicted				AlphaFoldDB

349 variants for P49760

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1374504332 CA342706973	2	P>L		No	TOPMed gnomAD ClinGen
rs1331576395 CA342706921	3	H>Q		No	gnomAD ClinGen
CA1143311 rs547649719	3	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs377306413 CA1143310	4	P>S		No	ESP ExAC TOPMed gnomAD ClinGen
CA30886100 rs377306413	4	P>T		No	ESP ExAC TOPMed gnomAD ClinGen
CA342706874 rs766279692	5	R>*		No	ClinGen ExAC TOPMed gnomAD
CA1143309 rs766279692	5	R>G		No	ExAC TOPMed gnomAD ClinGen
rs776525886 CA1143308	5	R>P		No	ExAC TOPMed gnomAD ClinGen
CA30886095 rs776525886	5	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs143471041 CA1143307	6	R>K		No	ClinGen ESP ExAC gnomAD
CA342706716 rs1341549419	8	H>L		No	ClinGen TOPMed gnomAD
CA342706719 rs1341549419	8	H>P		No	TOPMed gnomAD ClinGen
rs1180828272 CA342706684	10	S>T		No	ClinGen TOPMed
CA342706626 rs761469877	12	R>P		No	ClinGen ExAC TOPMed gnomAD
CA1143305 rs761469877	12	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs776026424 CA1143304	13	G>R		No	ClinGen ExAC gnomAD
TCGA novel	14	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1143301 rs776199117	15	R>L		No	ExAC TOPMed gnomAD ClinGen
COSM1741830 rs776199117 CA1143302	15	R>Q	urinary_tract [Cosmic]	No	ExAC TOPMed gnomAD ClinGen cosmic curated
CA1143303 rs768170507	15	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
CA342706493 rs1414830821	16	G>A		No	ClinGen TOPMed gnomAD
CA30886069 rs770813929	17	S>N		No	ClinGen Ensembl
rs12749700 COSM896858 CA1143296	19	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA1143294 rs756263438	19	R>H		No	ExAC TOPMed gnomAD ClinGen
CA1143295 rs12749700	19	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	20	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1143292 rs780028946	21	H>R		No	ExAC TOPMed gnomAD ClinGen
CA342706246 rs1175437235	21	H>Y		No	ClinGen TOPMed gnomAD
CA1143290 rs750231467	23	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs367780359 CA1143291	23	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1143289 rs765032461	24	S>R		No	ExAC TOPMed gnomAD ClinGen
CA342706057 rs761402681	25	R>L		No	ExAC TOPMed gnomAD ClinGen
CA1143288 rs761402681	25	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs772830334 CA30886022	29	R>*		No	ClinGen Ensembl
rs1182369122 CA342705933	29	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1203747560 CA342705915	30	R>Q		No	ClinGen TOPMed
CA342705890 rs1439632421	31	R>K		No	ClinGen gnomAD
CA1143286 rs199688580	33	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs199688580 CA1143285	33	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA342705794 rs760329747	33	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
CA1143284 rs760329747	33	R>L		No	ClinGen ExAC gnomAD
rs775074284 CA1143283	34	S>A		No	ClinGen ExAC gnomAD
CA342705767 rs775074284	34	S>P		No	ExAC gnomAD ClinGen
rs772720347 CA1143282	37	S>G		No	ExAC TOPMed gnomAD ClinGen
CA30886001 rs566634888	37	S>N		No	Ensembl ClinGen
CA1143280 rs141175277	38	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA342705580 rs1444942424	39	S>N		No	TOPMed gnomAD ClinGen
CA342705579 rs1444942424	39	S>T		No	ClinGen TOPMed gnomAD
TCGA novel	40	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761583683 CA30885997	40	D>Y		No	ClinGen gnomAD
rs749596664 CA342705531	41	R>G		No	ClinGen ExAC gnomAD
rs563407962 CA342705527	41	R>P		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA1143277 rs563407962	41	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs749596664 CA1143278	41	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA30885994 rs187700818	42	T>I		No	ClinGen 1000Genomes gnomAD
rs1166994501 CA342705519	42	T>P		No	TOPMed ClinGen
TCGA novel	43	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342705473 rs1572022122	43	R>Q		No	ClinGen Ensembl
rs1466665990 CA342705464	44	R>Q		No	ClinGen TOPMed
CA1143276 rs577592800	44	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781186813 CA1143274	45	R>C		No	ClinGen ExAC gnomAD
rs140726494 CA1143273	45	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1143272 rs745763311	46	R>Q	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA342705433 rs1375518303	46	R>W		No	TOPMed gnomAD ClinGen
CA1143271 rs373922154 COSM1498618	47	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen cosmic curated NCI-TCGA
CA1143270 rs757135453	48	E>D		No	ClinGen ExAC gnomAD
rs926850657 CA30885949	48	E>G		No	TOPMed ClinGen
rs753573218 CA1143269	49	D>N		No	ClinGen ExAC TOPMed gnomAD
CA30885938 rs983903046	52	H>R		No	TOPMed ClinGen
rs200641226 CA1143266	54	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs767100429 CA1143265	54	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA342705140 rs1210319635	55	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	TOPMed ClinGen NCI-TCGA
rs1557936784 CA342705125	56	R>*		No	ClinGen Ensembl
CA1143264 rs146590055	56	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1461851557 CA342704635	59	Y>C		No	TOPMed gnomAD ClinGen
rs1460983451 CA342704554	61	D>V		No	ClinGen gnomAD
CA1143238 rs146292560	62	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	1000Genomes ExAC gnomAD ClinGen NCI-TCGA
rs140461010 CA1143237	62	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC gnomAD ClinGen NCI-TCGA
rs200236285 CA1143236	63	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs866145868 CA30885222	64	S>F		No	ClinGen Ensembl
rs201508123 CA1143232	65	D>N		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA1143230 rs760538057	66	R>Q		No	ExAC TOPMed gnomAD ClinGen
CA1143231 rs151218471	66	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs747946686 CA1143229	68	V>L		No	ClinGen ExAC TOPMed gnomAD
CA1143228 rs781055739	69	Y>C		No	ExAC TOPMed gnomAD ClinGen
CA1143227 rs754608592	70	D>G		No	ClinGen ExAC gnomAD
CA342704181 rs1001352514	71	R>G		No	TOPMed gnomAD ClinGen
CA1143226 rs773202479	71	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs1001352514 CA30885168	71	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	TOPMed gnomAD ClinGen NCI-TCGA
TCGA novel	72	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342704148 rs1435869687	72	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	TOPMed gnomAD ClinGen NCI-TCGA
rs1210374181 CA342704033	75	G>D		No	ClinGen TOPMed
rs1459763850 CA342704045	75	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA342703981 rs1408372748	76	S>R		No	ClinGen gnomAD
CA342703967 rs1419043196	77	Y>C		No	gnomAD ClinGen
CA342703941 rs1455849940	78	R>G		No	ClinGen gnomAD
rs1251740272 CA342703917	78	R>I		No	gnomAD ClinGen
CA1143222 rs201974382	79	R>C		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA1143220 rs771757999	79	R>H		No	ExAC TOPMed gnomAD ClinGen
CA1143221 rs771757999	79	R>L		No	ClinGen ExAC TOPMed gnomAD
CA342703891 rs771757999	79	R>P		No	ClinGen ExAC TOPMed gnomAD
rs764316833 CA1143219	81	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs760760459 CA1143218	82	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs772087495 CA1143216 COSM239345	84	R>Q	prostate [Cosmic]	No	ExAC TOPMed gnomAD ClinGen cosmic curated
CA1143217 rs775672278	84	R>W		No	ClinGen ExAC gnomAD
TCGA novel	85	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769853194 CA1143214	86	R>G		No	ExAC TOPMed gnomAD ClinGen
rs1026872571 CA30885091	86	R>Q		No	TOPMed gnomAD ClinGen
CA1143213 rs769853194	86	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1300015211 CA342703657	87	G>R		No	ClinGen gnomAD
rs1487688989 CA342703585	88	D>G		No	Ensembl ClinGen
rs1440069903 CA342703606	88	D>H		No	ClinGen gnomAD
CA342703574 rs1246373607	89	A>T		No	Ensembl ClinGen
rs1370257671 CA342703567	89	A>V		No	ClinGen gnomAD
rs994507989 CA342703513	90	Y>C		No	TOPMed ClinGen
rs994507989 CA30885087	90	Y>F		No	ClinGen TOPMed
rs747958840 CA1143212	91	Y>C		No	ExAC TOPMed ClinGen
CA30885075 rs200422260	92	D>G		No	1000Genomes gnomAD ClinGen
rs1405039435 CA342703424	93	T>A		No	TOPMed ClinGen
CA342703410 rs1393584577	93	T>I		No	ClinGen gnomAD
rs768373002 CA1143210	94	D>Y		No	ExAC TOPMed gnomAD ClinGen
CA1143209 rs779725189 COSM1334610	95	Y>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1143208 rs779725189	95	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA1143206 rs201143899	96	R>Q		No	1000Genomes ESP ExAC gnomAD ClinGen
CA342703346 rs1479365780	96	R>W		No	TOPMed gnomAD ClinGen
CA1143205 rs779399122	98	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs757704895 CA1143204	99	Y>C		No	ExAC TOPMed gnomAD ClinGen
rs1309048156 CA342703145	101	Y>C		No	ClinGen gnomAD
CA342703155 rs1361010427	101	Y>H		No	TOPMed gnomAD ClinGen
CA342703116 rs1222192857	102	Q>*		No	gnomAD ClinGen
CA30884995 rs761073274	102	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA342703078 rs1416811814	103	R>Q		No	gnomAD ClinGen
rs1294139605 CA342703096	103	R>W		No	TOPMed gnomAD ClinGen
CA342702942 rs1374050701	107	S>N		No	gnomAD ClinGen
CA342702909 rs1302674849	108	Y>C		No	gnomAD ClinGen
CA342702917 rs1183600208	108	Y>H		No	ClinGen TOPMed
CA1143200 rs139555196	109	R>C		No	ESP ExAC TOPMed gnomAD ClinGen
rs1347527146 CA342702880	109	R>H		No	TOPMed gnomAD ClinGen
CA30884980 rs139555196	109	R>S		No	ESP ExAC TOPMed gnomAD ClinGen
CA342702824 rs1157486372	111	Q>K		No	TOPMed gnomAD ClinGen
CA342702814 rs1471328129	111	Q>R		No	ClinGen gnomAD
rs144510106 CA1143199	112	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA342702782 rs1188249873	112	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs1476014274 CA342702765	113	S>G		No	ClinGen gnomAD
CA1143198 rs759604508	113	S>N		No	ExAC gnomAD ClinGen
rs369467509 CA1143196	115	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs774503604 CA1143197	115	R>W		No	ClinGen ExAC TOPMed gnomAD
rs768375384 CA1143194 COSM122198	116	R>S	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
TCGA novel	117	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA30884917 rs989038220	120	R>Q		No	TOPMed gnomAD ClinGen
CA1143191 rs766225958	120	R>W		No	ExAC TOPMed gnomAD ClinGen
CA342702524 rs771750477	121	R>G		No	ClinGen ExAC TOPMed gnomAD
rs201854491 CA1143189	121	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA1143190 rs771750477	121	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs138362443 CA1143188	124	R>C		No	ESP ExAC TOPMed gnomAD ClinGen
CA1143187 rs757792688	124	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs551504532 CA1143185	126	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1143186 rs375441160	126	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756498577 CA1143184	128	F>L		No	ExAC gnomAD ClinGen
CA1143183 rs374127255	130	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs767641115 CA1143182	130	R>H		No	ClinGen ExAC TOPMed gnomAD
rs755167954 CA1143181	131	S>P		No	ExAC TOPMed gnomAD ClinGen
rs1186333457 CA342702088	133	S>L		No	ClinGen TOPMed gnomAD
rs1305733956 CA342700310	134	Q>R		No	gnomAD ClinGen
rs767387241 CA1143152	135	H>R		No	ExAC gnomAD ClinGen
rs1395411616 CA342700143	136	S>G		No	ClinGen gnomAD
rs1378931801 CA342700093	136	S>R		No	ClinGen Ensembl
CA342700009 rs1477026654	138	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs1175461757 CA342700012	138	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA342699999 rs1376963596	139	R>G		No	gnomAD ClinGen
TCGA novel	139	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1182701451 CA342699994	139	R>K		No	gnomAD ClinGen
CA1143151 rs759306469	140	A>P		No	ExAC gnomAD ClinGen
rs866964574 CA30884416	142	S>R		No	ClinGen Ensembl
CA1143150 rs774051104	146	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
rs1481030425 CA342699608	147	A>T		No	ClinGen TOPMed
CA1143147 rs368035965	155	V>I		No	ClinGen ESP ExAC gnomAD
CA1143146 rs770221235	160	Q>K		No	ExAC gnomAD ClinGen
rs748644267 CA1143145	161	E>K		No	ExAC gnomAD ClinGen
TCGA novel	162	R>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs533711087 CA1143126	166	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1411043333 CA342698468	167	S>N		No	ClinGen TOPMed
rs780507898 CA1143121	175	G>S		No	ExAC gnomAD ClinGen
rs1402327889 COSM896854 CA342698104	176	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs746358026 CA1143120	176	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA342698042 rs1572017847	178	V>A		No	ClinGen Ensembl
CA342697928 rs1462026099	181	V>F		No	ClinGen gnomAD
CA1143118 rs781752901	184	R>C		No	ExAC TOPMed gnomAD ClinGen
CA1143117 rs187165846	184	R>H		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs753861220 CA1143116	185	R>G		No	ExAC ClinGen
CA1143100 rs770993954	188	A>S		No	ExAC gnomAD ClinGen
rs749403911 CA1143099	188	A>V		No	ClinGen ExAC gnomAD
CA1143097 rs201284792	189	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	196	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1215910765 CA342697205	200	K>*		No	TOPMed ClinGen
CA342696930 rs1291897471	204	A>T		No	ClinGen TOPMed gnomAD
CA1143092 rs564730169	206	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1355390646 CA342696620	210	N>D		No	gnomAD ClinGen
COSM529316 rs1310022416 CA342696600	210	N>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs756802558 CA1143090	211	V>A		No	ClinGen ExAC TOPMed gnomAD
CA342696394 rs1170981353	216	N>H		No	ClinGen TOPMed
CA30883866 rs961903526	221	D>N		No	TOPMed gnomAD ClinGen
CA342696152 rs1401321012	222	N>D		No	ClinGen TOPMed
CA1143086 rs143729992	223	K>N		No	ESP ExAC TOPMed gnomAD ClinGen
rs1317694393 CA342696082	223	K>R		No	TOPMed ClinGen
rs1317694393 CA342696091	223	K>T		No	TOPMed ClinGen
rs1344067937 CA342694761	224	N>K		No	gnomAD ClinGen
rs753594210 CA1143068	225	L>F	Variant assessed as Somatic; 4.626e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1143067 rs777555478	226	C>Y		No	ClinGen ExAC gnomAD
TCGA novel	229	M>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1432171217 CA342694631	229	M>I		No	gnomAD ClinGen
CA30883110 rs1030201676	230	F>L		No	TOPMed gnomAD ClinGen
rs752190602 CA1143065	232	W>C		No	ClinGen ExAC gnomAD
rs1236460336 CA342694405	235	Y>C		No	ClinGen gnomAD
CA342694208 CA342694198 rs1425362515	239	M>I		No	TOPMed gnomAD ClinGen
rs759915329 CA1143063	239	M>V		No	ExAC gnomAD ClinGen
CA342693825 rs1253764511	247	G>D		No	ClinGen gnomAD
CA342693786 rs1572015492	248	L>R		No	ClinGen Ensembl
TCGA novel	252	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	254	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342693322 rs1557933159	258	N>K		No	ClinGen Ensembl
rs962276315 CA30883083	258	N>S		No	TOPMed ClinGen
CA1143061 rs766689748	263	P>A		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	263	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342693070 rs766689748	263	P>S		No	ClinGen ExAC TOPMed gnomAD
rs763277877 CA1143060	265	H>Y		No	ClinGen ExAC gnomAD
rs772583996 CA30883070	267	V>A		No	ClinGen Ensembl
COSM3740692 CA1143059 rs773477474	268	R>C	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM1201407 CA1143058 rs769997230	268	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs145678484 CA1143056	269	H>N		No	ESP ExAC TOPMed gnomAD ClinGen
CA342692858 rs1319057560	270	M>V		No	gnomAD ClinGen
CA342692802 rs894521183 COSM1600919 CA30883046	272	F>L	liver [Cosmic]	No	gnomAD ClinGen cosmic curated
rs142261254 CA30883052 COSM1600919	272	F>L	liver [Cosmic]	No	ESP TOPMed ClinGen cosmic curated
rs1012915404 CA30883049	272	F>S		No	ClinGen Ensembl
CA342692667 rs1293776904	276	Q>H		No	gnomAD ClinGen
rs772069185 CA1143055	279	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1465813637 CA342692587	279	K>T		No	ClinGen TOPMed
rs1557932429 CA342691383	303	Y>*		No	Ensembl ClinGen
rs546295338 CA30882560	305	L>F		No	1000Genomes ClinGen
rs773095255 CA1143033	309	L>I		No	ClinGen ExAC TOPMed gnomAD
CA342691107 rs1173638120	311	K>E		No	ClinGen gnomAD
CA1143006 rs779179029	313	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA30881554 rs1038581662	315	E>D		No	TOPMed gnomAD ClinGen
CA342689369 rs1485987205	316	R>C		No	TOPMed ClinGen
CA1143005 rs779370556	316	R>H		No	ExAC TOPMed gnomAD ClinGen
CA342689209 rs1553224310	321	T>A		No	ClinGen Ensembl
rs1158621556 CA342689108	322	A>D		No	gnomAD ClinGen
CA342689181 rs1245603899	322	A>T		No	TOPMed ClinGen
CA1143004 rs139698018	323	V>M		No	ESP ExAC TOPMed gnomAD ClinGen
rs749488583 CA1143003	324	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	324	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1143000 rs752753326	335	H>R		No	ClinGen ExAC TOPMed gnomAD
rs759670888 CA1142998	341	I>V		No	ClinGen ExAC gnomAD
CA342688126 rs1356582454	342	V>F		No	gnomAD ClinGen
rs1382022788 CA342687699	350	P>L		No	ClinGen gnomAD
rs1553224286 CA342687318	357	G>R		No	Ensembl ClinGen
rs979260595 CA30881386	362	C>S		No	ClinGen TOPMed
rs1487463579 CA342686807	367	I>V		No	ClinGen TOPMed
CA342686613 rs1178889023	372	F>I		No	TOPMed ClinGen
CA1142977 rs761763945	375	Y>F		No	ClinGen ExAC gnomAD
CA342686310 rs1156729216	379	T>I		No	TOPMed ClinGen
CA342686288 rs1420261248	380	L>V		No	ClinGen TOPMed
TCGA novel	382	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	386	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756330013 CA30881199	387	R>G		No	Ensembl ClinGen
CA342685952 rs1411657034	387	R>K		No	ClinGen TOPMed
rs374917896 CA1142961	391	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA342685614 rs1232264391	395	R>S		No	gnomAD ClinGen
CA342685502 rs1210667925	398	G>D		No	ClinGen gnomAD
CA342685432 rs758379259	400	I>F		No	ClinGen ExAC TOPMed gnomAD
rs758379259 CA1142959	400	I>L		No	ExAC TOPMed gnomAD ClinGen
rs758379259 CA342685436	400	I>V		No	ExAC TOPMed gnomAD ClinGen
rs753864417 CA1142958	402	S>F		No	ExAC TOPMed gnomAD ClinGen
CA1142955 rs752431100	403	R>P		No	ExAC TOPMed gnomAD ClinGen
CA1142956 rs752431100	403	R>Q		No	ExAC TOPMed gnomAD ClinGen
CA342685314 rs1572011721	403	R>W		No	Ensembl ClinGen
rs148639197 CA1142953	406	R>G		No	ESP ExAC TOPMed gnomAD ClinGen
CA1142952 rs534718482 COSM1334608	406	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1165286297 CA342684868	410	K>N		No	ClinGen gnomAD
rs1425273085 CA342684861	411	Q>E		No	gnomAD ClinGen
CA1142931 rs139015683	412	K>I		No	ESP ExAC gnomAD ClinGen
COSM3849288 CA1142929 rs368819963	416	R>W	pancreas [Cosmic]	No	ESP ExAC gnomAD ClinGen cosmic curated
CA342684532 COSM239343 rs1410623667	418	R>C	Variant assessed as Somatic; impact. prostate [NCI-TCGA, Cosmic]	No	TOPMed ClinGen cosmic curated NCI-TCGA
CA1142927 rs777248821	418	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs777248821 CA1142928	418	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1055840529 CA30880881	420	D>N		No	TOPMed gnomAD ClinGen
rs769193580 CA1142926	422	D>N		No	ClinGen ExAC TOPMed gnomAD
rs937909218 CA30880875	424	N>D		No	ClinGen TOPMed
CA1142925 rs747366037	425	T>A		No	ClinGen ExAC gnomAD
rs920869976 CA30880856	426	S>T		No	Ensembl ClinGen
CA1142924 rs374761483	428	G>E		No	ClinGen ESP ExAC gnomAD
TCGA novel	428	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342684159 rs1320246214	429	R>C		No	TOPMed gnomAD ClinGen
rs1314989986 CA342684151	429	R>H		No	ClinGen TOPMed gnomAD
COSM3802099 rs959560795 CA30880852	430	Y>C	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	Ensembl ClinGen cosmic curated NCI-TCGA
CA1142923 rs759554148	432	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
RCV000974861 CA1142922 rs138254335	432	R>H		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA342683978 rs138254335	432	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA342683999 rs759554148	432	R>S		No	ExAC TOPMed gnomAD ClinGen
rs751530422 CA30880840	433	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	Ensembl ClinGen NCI-TCGA
CA342683928 rs1224497403	434	N>Y		No	TOPMed ClinGen
CA1142920 rs757293960	436	K>R		No	ExAC gnomAD ClinGen
CA1142919 rs748129698 COSM1668028	437	P>L	large_intestine Variant assessed as Somatic; 4.619e-05 impact. [Cosmic, NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen cosmic curated NCI-TCGA
rs754830374 CA1142917	439	R>Q		No	ExAC TOPMed gnomAD ClinGen
CA342683720 rs1278093582	439	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs748615667 CA1142897	440	R>W		No	ClinGen ExAC TOPMed gnomAD
CA1142896 rs139671051	441	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA342683376 rs1364614857	443	T>I		No	gnomAD ClinGen
CA30880478 rs1019418225	444	S>P		No	Ensembl ClinGen
CA342683289 rs1484202557	448	E>D		No	gnomAD ClinGen
rs890531904 CA30880463	448	E>Q		No	Ensembl ClinGen
rs756894509 CA1142892 COSM896847	454	D>N	Variant assessed as Somatic; 4.645e-05 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ExAC gnomAD ClinGen cosmic curated NCI-TCGA
rs369716792 CA1142890	455	L>V		No	ESP ExAC TOPMed gnomAD ClinGen
CA30880424 rs150456292	459	M>T		No	ESP TOPMed ClinGen
CA342682908 rs1321048899	461	E>G		No	ClinGen TOPMed gnomAD
CA342682811 rs1410216383	464	P>T		No	gnomAD ClinGen
CA30880411 rs1049090	465	A>V		No	ClinGen Ensembl
rs774619061 CA342682672	469	T>I		No	ClinGen ExAC gnomAD
CA1142886 rs759928699	469	T>P		No	ExAC TOPMed gnomAD ClinGen
rs774619061 CA1142885	469	T>S		No	ExAC gnomAD ClinGen
rs1304721156 CA342682626	470	L>F		No	gnomAD ClinGen
rs534870900 CA1142883	471	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1456924579 CA342682588	472	E>K		No	TOPMed ClinGen
rs1428863605 CA342682536	474	L>V		No	gnomAD ClinGen
rs773231332 CA1142882	477	P>L		No	ClinGen ExAC gnomAD
CA1142880 rs746962823	480	A>T	Variant assessed as Somatic; 9.271e-05 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs780021739 CA1142879	480	A>V		No	ClinGen ExAC TOPMed gnomAD
CA1142878 rs771821636	481	R>C	Variant assessed as Somatic; 4.636e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs745674031 CA1142877	481	R>H		No	ClinGen ExAC TOPMed gnomAD
rs745674031 CA342682281	481	R>P		No	ClinGen ExAC TOPMed gnomAD
CA342682285 rs771821636	481	R>S		No	ExAC TOPMed gnomAD ClinGen
CA342682243 rs1205035966	482	L>R		No	gnomAD ClinGen
rs200444017 CA1142875	483	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753428819 CA30880326	483	R>P		No	ExAC gnomAD ClinGen
CA1142874 rs753428819	483	R>Q		No	ClinGen ExAC gnomAD
rs200444017 CA1142876	483	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs768060382 CA1142870	486	P>L		No	ClinGen ExAC TOPMed gnomAD
CA30880292 rs1046542228	487	P>R		No	Ensembl ClinGen
CA1142868 rs751860229	488	N>Y		No	ExAC gnomAD ClinGen
CA1142867 rs147637184	489	K>N		No	ClinGen ESP ExAC TOPMed
rs1222174111 CA342681895	490	L>F		No	ClinGen TOPMed
CA342681823 rs1450579498	491	W>C		No	ClinGen gnomAD
CA1142865 rs763125375	492	D>A		No	ClinGen ExAC gnomAD
CA342681760 rs1557929673	493	S>C		No	ClinGen Ensembl
CA30880250 rs773395300	494	S>G		No	ExAC gnomAD ClinGen
rs1459059706 CA342681734	494	S>N		No	gnomAD ClinGen
CA1142864 rs773395300	494	S>R		No	ExAC gnomAD ClinGen
TCGA novel	495	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1158415401 CA342681646	496	D>G		No	ClinGen TOPMed gnomAD

No associated diseases with P49760

3 regional properties for P49760

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	163 - 479	IPR000719
active_site	Serine/threonine-protein kinase, active site	286 - 298	IPR008271
binding_site	Protein kinase, ATP binding site	169 - 193	IPR017441

Functions

		Description
EC Number	2.7.12.1	Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization	Nucleus ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

6 GO annotations of biological process

Name	Definition
negative regulation of gluconeogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
peptidyl-tyrosine phosphorylation	The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of RNA splicing	Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
response to ionizing radiation	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P49761	CLK3	Dual specificity protein kinase CLK3	Homo sapiens (Human)	PR
P51566	AFC1	Serine/threonine-protein kinase AFC1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MPHPRRYHSS	ERGSRGSYRE	HYRSRKHKRR	RSRSWSSSSD	RTRRRRREDS	YHVRSRSSYD
70	80	90	100	110	120
DRSSDRRVYD	RRYCGSYRRN	DYSRDRGDAY	YDTDYRHSYE	YQRENSSYRS	QRSSRRKHRR
130	140	150	160	170	180
RRRRSRTFSR	SSSQHSSRRA	KSVEDDAEGH	LIYHVGDWLQ	ERYEIVSTLG	EGTFGRVVQC
190	200	210	220	230	240
VDHRRGGARV	ALKIIKNVEK	YKEAARLEIN	VLEKINEKDP	DNKNLCVQMF	DWFDYHGHMC
250	260	270	280	290	300
ISFELLGLST	FDFLKDNNYL	PYPIHQVRHM	AFQLCQAVKF	LHDNKLTHTD	LKPENILFVN
310	320	330	340	350	360
SDYELTYNLE	KKRDERSVKS	TAVRVVDFGS	ATFDHEHHST	IVSTRHYRAP	EVILELGWSQ
370	380	390	400	410	420
PCDVWSIGCI	IFEYYVGFTL	FQTHDNREHL	AMMERILGPI	PSRMIRKTRK	QKYFYRGRLD
430	440	450	460	470	480
WDENTSAGRY	VRENCKPLRR	YLTSEAEEHH	QLFDLIESML	EYEPAKRLTL	GEALQHPFFA
490
RLRAEPPNKL	WDSSRDISR