AiPD: Autoinhibited Protein Database

P51398

Gene name	DAP3 (MRPS29)
Protein name	28S ribosomal protein S29, mitochondrial
Names	MRP-S29, S29mt, Death-associated protein 3, DAP-3, Ionizing radiation resistance conferring protein, Mitochondrial small ribosomal subunit protein mS29
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7818
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-100 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

5-100 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

43 structures for P51398

Entry ID	Method	Resolution	Chain	Position	Source
3J9M	EM	350 A	AX	1-398	PDB
6NU2	EM	390 A	AX	51-398	PDB
6NU3	EM	440 A	AX	1-398	PDB
6RW4	EM	297 A	X	1-398	PDB
6RW5	EM	314 A	X	1-398	PDB
6VLZ	EM	297 A	AX	1-398	PDB
6VMI	EM	296 A	AX	1-398	PDB
6ZM5	EM	289 A	AX	1-398	PDB
6ZM6	EM	259 A	AX	1-398	PDB
6ZS9	EM	400 A	AX	51-398	PDB
6ZSA	EM	400 A	AX	51-398	PDB
6ZSB	EM	450 A	AX	51-398	PDB
6ZSC	EM	350 A	AX	51-398	PDB
6ZSD	EM	370 A	AX	51-398	PDB
6ZSE	EM	500 A	AX	51-398	PDB
6ZSG	EM	400 A	AX	51-398	PDB
7A5F	EM	440 A	X6	1-398	PDB
7A5G	EM	433 A	X6	1-398	PDB
7A5I	EM	370 A	X6	1-398	PDB
7A5K	EM	370 A	X6	1-398	PDB
7L08	EM	349 A	AX	1-398	PDB
7OG4	EM	380 A	AX	1-398	PDB
7P2E	EM	240 A	X	1-398	PDB
7PNX	EM	276 A	X	1-398	PDB
7PNY	EM	306 A	X	1-398	PDB
7PNZ	EM	309 A	X	1-398	PDB
7PO0	EM	290 A	X	1-398	PDB
7PO1	EM	292 A	X	1-398	PDB
7PO2	EM	309 A	X	1-398	PDB
7PO3	EM	292 A	X	1-398	PDB
7QI4	EM	221 A	AX	1-398	PDB
7QI5	EM	263 A	AX	1-398	PDB
7QI6	EM	298 A	AX	1-398	PDB
8ANY	EM	285 A	AX	1-398	PDB
8CSP	EM	266 A	X	1-398	PDB
8CSQ	EM	254 A	X	1-398	PDB
8CSR	EM	254 A	X	1-398	PDB
8CSS	EM	236 A	X	1-398	PDB
8CST	EM	285 A	X	1-398	PDB
8CSU	EM	303 A	X	1-398	PDB
8OIR	EM	310 A	AX	1-398	PDB
8OIS	EM	300 A	AX	1-398	PDB
AF-P51398-F1	Predicted				AlphaFoldDB

333 variants for P51398

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA30989433 rs372811843	2	M>I		No	ClinGen ESP TOPMed gnomAD
rs61755343 CA1149136	5	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1410395608 CA342775069 COSM243954	5	G>R	prostate [Cosmic]	No	ClinGen cosmic curated Ensembl
rs61755343 CA1149137	5	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772166563 CA1149139	7	T>I		No	ClinGen ExAC
rs1432674029 CA342775098	8	R>G		No	ClinGen gnomAD
rs775495982 CA1149140	10	I>L		No	ClinGen ExAC gnomAD
rs760898731 CA1149141	12	R>K		No	ClinGen ExAC TOPMed gnomAD
CA342775152 rs1470221997	13	I>N		No	ClinGen TOPMed gnomAD
CA342775159 rs1397911722	14	H>D		No	ClinGen gnomAD
CA1149142 rs764152940	14	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1345656156 CA342763540	17	D>V		No	ClinGen gnomAD
CA342763559 rs1278123325	18	P>L		No	ClinGen gnomAD
TCGA novel	19	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770793096 COSM243953 CA1149159	20	R>C	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM896969 rs1274099843 CA342763578	20	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs560216710 CA342763627	23	H>P		No	ClinGen 1000Genomes
CA30936823 rs560216710	23	H>R		No	ClinGen 1000Genomes
rs775549205 CA1149160	24	M>T		No	ClinGen ExAC TOPMed gnomAD
CA342763639 rs1557781464	24	M>V		No	ClinGen Ensembl
CA342763687 rs1571507494	26	T>I		No	ClinGen Ensembl
CA342763678 rs1333441738	26	T>S		No	ClinGen Ensembl
CA342763692 rs1490553650	27	Q>*		No	ClinGen gnomAD
CA1149164 rs145929335	29	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1149165 rs369774038	29	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA1149166 rs370992701	31	S>G		No	ClinGen ESP ExAC gnomAD
TCGA novel	31	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200523835 CA1149167	32	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1149168 rs763561074	32	I>S		No	ClinGen ExAC gnomAD
rs200523835 CA30936958	32	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1019811247 CA30936959	34	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA342763815 rs1418571902	35	H>R		No	ClinGen TOPMed gnomAD
rs1365737302 CA342763810 COSM3802125	35	H>Y	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1295753368 CA342763831	36	L>R		No	ClinGen gnomAD
rs752102492 CA1149170	38	N>K		No	ClinGen ExAC gnomAD
rs755677116 CA30936990	39	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs755677116 CA342763871	39	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA1149173 COSM896970 rs752327968	39	Q>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs755677116 CA1149171	39	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA1149172 rs146211768	39	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs925547082 CA30937004	40	V>F		No	ClinGen TOPMed
CA342763900 rs1317435523	41	P>A		No	ClinGen gnomAD
rs755738906 CA1149175	42	V>A		No	ClinGen ExAC gnomAD
rs755738906 CA1149174	42	V>D		No	ClinGen ExAC gnomAD
CA1149176 rs749012692	43	E>K		No	ClinGen ExAC gnomAD
rs757038621 CA1149177	44	S>R		No	ClinGen ExAC gnomAD
rs370236932 CA30937036	45	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA1149179 rs373966776	45	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs370236932 CA1149178	45	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA30937045 rs936896915	46	R>K		No	ClinGen TOPMed gnomAD
rs1185138220 CA342764008	48	I>V		No	ClinGen gnomAD
rs1385496823 CA342764034	49	S>F		No	ClinGen gnomAD
CA1149182 rs377474444	50	R>C		No	ClinGen ExAC TOPMed gnomAD
rs149919712 CA1149183 COSM1334693	50	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1319635829 CA342764058	51	T>I		No	ClinGen gnomAD
CA1149184 rs773565559	51	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1571508083 CA342764132	55	D>G		No	ClinGen Ensembl
CA30937095 rs201385663	56	P>L		No	ClinGen TOPMed gnomAD
rs774733542 CA1149205	58	K>N		No	ClinGen ExAC gnomAD
rs1321458708 CA342764968	59	H>R		No	ClinGen TOPMed gnomAD
CA1149206 rs759970366	59	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1357449951 CA342764972	60	G>R		No	ClinGen TOPMed
CA1149207 rs767996923	61	D>N		No	ClinGen ExAC gnomAD
CA1149208 rs775853011	61	D>V		No	ClinGen ExAC gnomAD
CA342764994 rs1411226963	63	H>Y		No	ClinGen TOPMed
rs1196459888 CA342765000	64	E>K		No	ClinGen TOPMed gnomAD
CA342765003 rs1443574435	64	E>V		No	ClinGen TOPMed
CA342765010 rs763570884	65	G>D		No	ClinGen ExAC gnomAD
rs879023821 CA342765008	65	G>R		No	ClinGen gnomAD
CA30939461 rs879023821	65	G>S		No	ClinGen gnomAD
rs763570884 CA1149210	65	G>V		No	ClinGen ExAC gnomAD
CA342765016 rs1256281261	66	Q>R		No	ClinGen TOPMed
CA342765032 rs1437998180	68	Y>C		No	ClinGen gnomAD
TCGA novel	68	Y>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753527370 CA1149211	69	N>S		No	ClinGen ExAC TOPMed gnomAD
rs112771778 CA1149215	71	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs112771778 CA1149214	71	S>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1481123806 CA342765056	72	P>S		No	ClinGen gnomAD
CA1149217 rs758124736	73	Q>K		No	ClinGen ExAC gnomAD
rs1465445158 CA342765063	73	Q>L		No	ClinGen TOPMed gnomAD
rs757230517	73	Q>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs757230517	73	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA342765064 rs1465445158	73	Q>R		No	ClinGen TOPMed gnomAD
rs751431768 CA1149219	80	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1391190094 CA342765120	81	H>Q		No	ClinGen TOPMed
rs374151645 CA1149220	81	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs187192135 CA30939500	81	H>Y		No	ClinGen 1000Genomes TOPMed
CA30939515 rs1802737	83	L>F		No	ClinGen Ensembl
CA342765137 rs1283859728	84	P>L		No	ClinGen gnomAD
rs749547998 CA1149222	86	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1224997587 CA342765146	86	R>H		No	ClinGen gnomAD
CA1149224 rs779146216	88	V>A		No	ClinGen ExAC gnomAD
rs766255365 CA30939524 CA1149225	89	M>I		No	ClinGen ExAC TOPMed gnomAD
CA342765171 rs1287295551	90	Q>*		No	ClinGen gnomAD
rs1571538948 CA342766565	92	K>E		No	ClinGen Ensembl
CA342766581 rs1239831582	93	T>A		No	ClinGen TOPMed
CA1149268 rs747307421	94	F>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	95	S>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1149269 rs755321949	98	C>Y		No	ClinGen ExAC gnomAD
CA1149270 rs781700081	107	E>K		No	ClinGen ExAC
CA1149271 rs748621976	108	L>I		No	ClinGen ExAC gnomAD
CA1149272 rs769374598	110	H>R		No	ClinGen ExAC TOPMed gnomAD
rs772546005 CA1149273	111	Y>D		No	ClinGen ExAC gnomAD
rs748979582 CA1149274	112	L>V		No	ClinGen ExAC gnomAD
CA342766821 rs1330274964	115	T>S		No	ClinGen gnomAD
rs1557790875 CA342766839	116	S>N		No	ClinGen Ensembl
CA1149275 rs147691190	117	F>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1392652652 CA342766871	118	A>V		No	ClinGen gnomAD
rs548531604 CA1149277	120	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	121	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342766904 rs1223493932	121	A>S		No	ClinGen gnomAD
TCGA novel	121	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1149278 rs138952726	122	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA342766914 rs1440910600	122	I>V		No	ClinGen TOPMed gnomAD
CA30941951 rs916908988	123	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs567143323 CA1149279	124	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs1204642983 CA342766933	124	Y>H		No	ClinGen gnomAD
TCGA novel	127	Y>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342766966 rs1479757419	127	Y>H		No	ClinGen gnomAD
CA30942357 rs200299293	129	E>Q		No	ClinGen TOPMed gnomAD
rs1244860052 CA342767313	130	K>R		No	ClinGen gnomAD
rs751809259 CA1149303	131	G>E		No	ClinGen ExAC gnomAD
CA1149304 rs759703250	132	T>I		No	ClinGen ExAC TOPMed gnomAD
CA1149305 rs759703250	132	T>R		No	ClinGen ExAC TOPMed gnomAD
CA342767334 rs1288779045	134	K>E		No	ClinGen gnomAD
CA1149306 rs752934883	134	K>N		No	ClinGen ExAC gnomAD
CA342767336 rs1360393656	134	K>R		No	ClinGen gnomAD
rs1024150834 CA30942388	135	T>A		No	ClinGen TOPMed gnomAD
CA342767347 rs1243912189	136	L>P		No	ClinGen gnomAD
rs1358938352 CA342767345	136	L>V		No	ClinGen gnomAD
CA1149307 rs756492236	138	L>F		No	ClinGen ExAC
rs1294098843 CA342767374	140	H>R		No	ClinGen gnomAD
CA1149308 rs778205623	141	V>L		No	ClinGen ExAC gnomAD
rs971530058 CA30942400	142	I>T		No	ClinGen Ensembl
rs756760074 CA1149310	144	F>S		No	ClinGen ExAC gnomAD
rs756760074 CA342767400	144	F>Y		No	ClinGen ExAC gnomAD
rs1186832758 CA342767416	146	A>G		No	ClinGen gnomAD
rs1486728831 CA342767413	146	A>P		No	ClinGen gnomAD
rs778529321 CA1149311	147	K>R		No	ClinGen ExAC TOPMed gnomAD
rs369933128 CA1149312	148	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA30942430 rs926948524	149	D>N		No	ClinGen TOPMed gnomAD
CA1149314 rs771793968	151	L>P		No	ClinGen ExAC gnomAD
TCGA novel	152	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1343886243 CA342767460	153	L>I		No	ClinGen TOPMed gnomAD
CA342767481 rs568206981	156	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs953049679 CA30942444	156	P>L		No	ClinGen TOPMed gnomAD
rs953049679 CA342767483	156	P>R		No	ClinGen TOPMed gnomAD
rs568206981 CA1149317	156	P>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs12096547 CA30942447	157	D>N		No	ClinGen Ensembl
rs768367176 CA1149338	158	A>G		No	ClinGen ExAC gnomAD
CA1149337 rs768367176	158	A>V		No	ClinGen ExAC gnomAD
rs1362816967 CA342767523	161	W>G		No	ClinGen TOPMed
rs1362816967 CA342767522	161	W>R		No	ClinGen TOPMed
CA1149340 rs769648994	162	V>M		No	ClinGen ExAC TOPMed
CA1149342 rs759666299	165	C>Y		No	ClinGen ExAC gnomAD
rs772121458 CA1149344	166	R>G		No	ClinGen ExAC TOPMed gnomAD
CA1149345 rs760914706	166	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs772121458 CA1149343	166	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA30943448 rs200493494	169	L>P		No	ClinGen 1000Genomes
rs202169688 CA30943449	170	Q>R		No	ClinGen 1000Genomes
rs146215312 CA1149347	172	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA342767618 rs1429125945	175	K>R		No	ClinGen gnomAD
CA342767617 rs1429125945	175	K>T		No	ClinGen gnomAD
rs762415303 CA1149348	176	Q>R		No	ClinGen ExAC gnomAD
rs1178975472 CA342767629	177	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1149349 rs141747463	177	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1149350 rs141747463 COSM3979878	177	R>L	ovary [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	180	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1149351 rs758021996	181	P>L		No	ClinGen ExAC gnomAD
CA1149352 rs765872809	182	L>*		No	ClinGen ExAC
rs1327083426 CA342767669	183	E>Q		No	ClinGen gnomAD
rs751192310 CA1149353	186	T>A		No	ClinGen ExAC TOPMed gnomAD
CA30943491 rs946995325	189	K>E		No	ClinGen TOPMed gnomAD
rs754599105 CA1149354	189	K>T		No	ClinGen ExAC gnomAD
rs201777168 CA1149355	192	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1232488909 CA342767746	194	T>I		No	ClinGen TOPMed
rs748000917 CA1149356	194	T>S		No	ClinGen ExAC gnomAD
CA1149357 rs755886022	196	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs150553683 CA1149359	197	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs772079263 CA1149360	197	R>H		No	ClinGen ExAC TOPMed gnomAD
CA1149361 rs775592927	198	F>L		No	ClinGen ExAC gnomAD
CA342767815 rs1451536392	202	I>M		No	ClinGen gnomAD
CA1149395 rs752381978	207	K>E		No	ClinGen ExAC TOPMed gnomAD
CA1149396 rs371263118	207	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs752381978 CA1149394	207	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs545683945 CA30944391	208	Y>C		No	ClinGen Ensembl
TCGA novel	210	W>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA30944400 rs975191251	212	K>E		No	ClinGen TOPMed gnomAD
CA30944409 rs760795857	212	K>R		No	ClinGen TOPMed
TCGA novel	213	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1149398 rs756999098 COSM3728009	213	R>T	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs778968624 CA1149399	214	E>G		No	ClinGen ExAC gnomAD
CA1149402 rs781370831	217	E>A		No	ClinGen ExAC gnomAD
rs1188280780 CA342767932	219	G>E		No	ClinGen gnomAD
rs748394462 CA1149403	221	P>L		No	ClinGen ExAC TOPMed gnomAD
rs748394462 CA1149404	221	P>R		No	ClinGen ExAC TOPMed gnomAD
CA342767955 rs1571553195	223	G>E		No	ClinGen Ensembl
rs1186080468 CA342767970	225	V>A		No	ClinGen TOPMed
CA1149406 rs749717538	226	V>D		No	ClinGen ExAC TOPMed gnomAD
rs1452874782 CA342767972	226	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	227	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	228	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA30944579 rs552936757	231	T>A		No	ClinGen Ensembl
CA342768018 rs757669207	231	T>K		No	ClinGen ExAC TOPMed gnomAD
CA1149427 rs757669207	231	T>R		No	ClinGen ExAC TOPMed gnomAD
rs145328544 CA342768021	232	R>L		No	ClinGen ESP ExAC gnomAD
CA1149429 rs145328544	232	R>P		No	ClinGen ESP ExAC gnomAD
CA30944612 rs145328544	232	R>Q		No	ClinGen ESP ExAC gnomAD
CA1149428 rs200984755	232	R>W		No	ClinGen ExAC TOPMed gnomAD
rs373985177 CA1149430	233	V>M		No	ClinGen ESP ExAC gnomAD
CA30944628 rs867839385	235	N>S		No	ClinGen Ensembl
CA30944632 rs868612639	236	A>T		No	ClinGen TOPMed gnomAD
CA342768055 rs1250903021	238	D>V		No	ClinGen gnomAD
CA1149432 rs147699097	239	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA342768062 rs1431045753	239	A>S		No	ClinGen TOPMed
CA342768064 rs147699097	239	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs776387238 CA1149435	240	V>A		No	ClinGen ExAC TOPMed gnomAD
RCV000974037 CA1149434 rs57692591 VAR_061811	240	V>F		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA1149436 rs761333313	246	E>*		No	ClinGen ExAC gnomAD
rs1437091159 CA342768119	248	K>N		No	ClinGen gnomAD
CA1149439 rs371226776	248	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA1149440 rs766481911	250	Q>R		No	ClinGen ExAC gnomAD
CA30944703 rs1802736	253	L>F		No	ClinGen Ensembl
rs751517938 CA342768155	254	G>R		No	ClinGen ExAC TOPMed gnomAD
CA1149441 rs751517938	254	G>S		No	ClinGen ExAC TOPMed gnomAD
CA1149442 rs756299657	254	G>V		No	ClinGen ExAC gnomAD
CA30944712 rs1025391605	255	M>T		No	ClinGen TOPMed gnomAD
rs764225657 CA1149443	257	H>P		No	ClinGen ExAC gnomAD
TCGA novel	261	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs536698370 CA1149448	262	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA30944760 rs750472379	263	D>G		No	ClinGen Ensembl
rs1305941570 CA342768222	264	G>V		No	ClinGen gnomAD
rs780589326 CA1149449	266	N>S		No	ClinGen ExAC gnomAD
CA342768241 rs1275503948	267	A>D		No	ClinGen TOPMed gnomAD
rs1275503948 CA342768242	267	A>G		No	ClinGen TOPMed gnomAD
rs754890180 CA1149450	268	L>F		No	ClinGen ExAC TOPMed gnomAD
CA1149451 rs754890180	268	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	271	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	271	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747840157 CA1149454	274	L>M		No	ClinGen ExAC gnomAD
rs1259275986 CA342768301	277	E>Q		No	ClinGen gnomAD
rs1450992107 CA342768324	278	D>E		No	ClinGen TOPMed gnomAD
rs375689451 CA1149456	281	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1149455 rs375689451	281	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs748905247 CA1149476	282	I>F		No	ClinGen ExAC TOPMed gnomAD
rs1571562477 CA342769023	282	I>T		No	ClinGen Ensembl
rs774233914 CA1149478	285	E>K		No	ClinGen ExAC TOPMed gnomAD
rs200201625 CA342769070	289	L>H		No	ClinGen 1000Genomes TOPMed
CA30946130 rs200201625	289	L>P		No	ClinGen 1000Genomes TOPMed
rs947849567 CA30946133	291	H>Q		No	ClinGen TOPMed gnomAD
CA342769092 rs1330963248 COSM1319909	292	N>K	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA342769099 rs1557799139	293	L>F		No	ClinGen Ensembl
rs137992488 CA30946134	294	R>S		No	ClinGen ESP gnomAD
rs775488543 CA1149481	295	K>E		No	ClinGen ExAC
CA1149482 rs200594001	296	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA342769124 rs1459731258	297	M>T		No	ClinGen gnomAD
CA342769123 rs1571562723	297	M>V		No	ClinGen Ensembl
CA1149483 rs765328982	300	D>E		No	ClinGen ExAC gnomAD
rs750677739 CA1149484	301	W>*		No	ClinGen ExAC TOPMed gnomAD
CA1149499 rs745719677	303	G>R		No	ClinGen ExAC TOPMed gnomAD
CA342769193 rs369936772	305	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs369936772 CA1149501	305	A>T	Variant assessed as Somatic; 4.675e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1477244495 CA342769197	306	I>V		No	ClinGen gnomAD
rs769788706 CA1149503	307	V>L		No	ClinGen ExAC TOPMed gnomAD
rs371707774 CA1149504	308	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA30946534 rs1021780329	309	A>P		No	ClinGen Ensembl
rs79717735 CA30946552	310	L>F		No	ClinGen gnomAD
CA342769284 rs1571564446	319	P>L		No	ClinGen Ensembl
rs766644128 CA1149506	320	R>G		No	ClinGen ExAC TOPMed gnomAD
rs759857997 CA1149508	320	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs766644128 CA1149507	320	R>W		No	ClinGen ExAC TOPMed gnomAD
CA1149510 rs753162108	322	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1041724474 CA342769306	323	Y>C		No	ClinGen TOPMed gnomAD
CA30946576 rs1041724474	323	Y>F		No	ClinGen TOPMed gnomAD
rs1228497740 CA342769310	324	L>V		No	ClinGen TOPMed
rs1571564561 CA342769318	325	P>L		No	ClinGen Ensembl
rs373125599 CA30946588	325	P>S		No	ClinGen Ensembl
rs767022342 CA1149512	326	Q>*		No	ClinGen ExAC gnomAD
CA342769324 rs1276218579	326	Q>H		No	ClinGen gnomAD
CA1149532 rs539027947	333	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1254239988 CA342769797	335	D>N		No	ClinGen gnomAD
CA1149533 rs750065441	336	A>T		No	ClinGen ExAC gnomAD
rs758012904 CA1149534	337	L>V		No	ClinGen ExAC gnomAD
CA342769831 rs1161147412	340	F>C		No	ClinGen gnomAD
CA342769828 rs1471502421	340	F>L		No	ClinGen gnomAD
rs984834933 CA30949222	342	P>L		No	ClinGen Ensembl
rs930724668 CA342769841	342	P>S		No	ClinGen gnomAD
rs930724668 CA30949217	342	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1149536 rs41264967	345	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1300706225 CA342769869	347	N>D		No	ClinGen gnomAD
rs1403724735 CA342769880	348	Y>C		No	ClinGen gnomAD
rs1557805320 CA342769896	350	P>R		No	ClinGen Ensembl
CA342769913 rs373938510	352	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	352	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1350365247 CA342769920	353	F>L		No	ClinGen gnomAD
CA342769919 rs1557805366	353	F>S		No	ClinGen Ensembl
rs940706352 CA30949229	356	C>R		No	ClinGen Ensembl
rs771017753 CA342769949	357	I>S		No	ClinGen ExAC TOPMed gnomAD
CA1149540 rs771017753	357	I>T		No	ClinGen ExAC TOPMed gnomAD
CA1149541 rs150623601	358	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1149543 rs772402501	364	N>S		No	ClinGen ExAC TOPMed gnomAD
CA342770010 rs1254420128 COSM896975	365	W>*	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	366	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA30949251 rs901113004	367	Q>*		No	ClinGen Ensembl
rs1411968226 CA342770034	369	E>K		No	ClinGen TOPMed
CA342770436 rs1571586421	374	E>A		No	ClinGen Ensembl
rs772026004 CA1149564	374	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772026004 CA342770431	374	E>Q		No	ClinGen ExAC gnomAD
TCGA novel	379	E>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342770572 rs1431035105 COSM529253	382	F>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs747163345 CA1149566	382	F>S		No	ClinGen ExAC gnomAD
rs769165051 CA1149568	383	L>V		No	ClinGen ExAC gnomAD
rs148826948 CA1149570	385	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773568256 CA1149571	386	A>T		No	ClinGen ExAC TOPMed gnomAD
CA1149572 rs762562887	386	A>V		No	ClinGen ExAC TOPMed gnomAD
CA342770650 rs1571586563	387	N>T		No	ClinGen Ensembl
CA30949762 rs953474208	388	P>R		No	ClinGen TOPMed gnomAD
CA30949756 rs1802733	388	P>T		No	ClinGen Ensembl
CA1149576 rs575591189	389	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759126801 CA1149575	389	S>P		No	ClinGen ExAC gnomAD
CA1149579 rs777818536	390	L>P		No	ClinGen ExAC gnomAD
TCGA novel	390	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA30949770 rs559561890	391	L>P		No	ClinGen Ensembl
rs536103220 CA1149580	392	E>K		No	ClinGen ExAC gnomAD
CA1149582 rs779948728	393	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1149581 rs758540792	393	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1450821688 CA342770708	394	H>Y		No	ClinGen gnomAD
CA1149584 rs111463064	395	C>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1149585 rs781562698	395	C>Y		No	ClinGen ExAC gnomAD
rs1466143859 CA342770725	396	A>V		No	ClinGen TOPMed
CA342770730 rs1423798192	397	Y>C		No	ClinGen gnomAD
CA342770736 rs1351987058	398	L>H		No	ClinGen gnomAD
CA1149586 rs748570143	398	L>V		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with P51398

No regional properties for P51398

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P51398

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial small ribosomal subunit	The smaller of the two subunits of a mitochondrial ribosome.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

3 GO annotations of molecular function

Name	Definition
GTP binding	Binding to GTP, guanosine triphosphate.
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

2 GO annotations of biological process

Name	Definition
apoptotic signaling pathway	The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
mitochondrial translation	The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q01163	RSM23	37S ribosomal protein S23, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P82922	DAP3	28S ribosomal protein S29, mitochondrial	Bos taurus (Bovine)	PR

10	20	30	40	50	60
MMLKGITRLI	SRIHKLDPGR	FLHMGTQARQ	SIAAHLDNQV	PVESPRAISR	TNENDPAKHG
70	80	90	100	110	120
DQHEGQHYNI	SPQDLETVFP	HGLPPRFVMQ	VKTFSEACLM	VRKPALELLH	YLKNTSFAYP
130	140	150	160	170	180
AIRYLLYGEK	GTGKTLSLCH	VIHFCAKQDW	LILHIPDAHL	WVKNCRDLLQ	SSYNKQRFDQ
190	200	210	220	230	240
PLEASTWLKN	FKTTNERFLN	QIKVQEKYVW	NKRESTEKGS	PLGEVVEQGI	TRVRNATDAV
250	260	270	280	290	300
GIVLKELKRQ	SSLGMFHLLV	AVDGINALWG	RTTLKREDKS	PIAPEELALV	HNLRKMMKND
310	320	330	340	350	360
WHGGAIVSAL	SQTGSLFKPR	KAYLPQELLG	KEGFDALDPF	IPILVSNYNP	KEFESCIQYY
370	380	390
LENNWLQHEK	APTEEGKKEL	LFLSNANPSL	LERHCAYL