P50478
Gene name |
AMPH |
Protein name |
Amphiphysin |
Names |
|
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:420761 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P50478
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P50478-F1 | Predicted | AlphaFoldDB |
No variants for P50478
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P50478 | |||||
No associated diseases with P50478
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| neuron projection terminus | The specialized, terminal region of a neuron projection such as an axon or a dendrite. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| synaptic vesicle membrane | The lipid bilayer surrounding a synaptic vesicle. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UBW5 | BIN2 | Bridging integrator 2 | Homo sapiens (Human) | PR |
| O00499 | BIN1 | Myc box-dependent-interacting protein 1 | Homo sapiens (Human) | PR |
| P49418 | AMPH | Amphiphysin | Homo sapiens (Human) | PR |
| O08539 | Bin1 | Myc box-dependent-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q7TQF7 | Amph | Amphiphysin | Mus musculus (Mouse) | PR |
| O08839 | Bin1 | Myc box-dependent-interacting protein 1 | Rattus norvegicus (Rat) | PR |
| O08838 | Amph | Amphiphysin | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADMKTGIFA | KNVQKRLNRA | QEKVLQKLGK | ADETKDEQFE | EYVQNFKRQE | AEGSRLQREL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RAYLAAIKGM | QDASKKLTES | LHEVYEPDWY | GREDVKMIGE | KCDELWEDFH | QKLVDGSLLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDTYLGQFPD | IKTRIAKRSR | KLVDYDSARH | HLEALQSSKR | KDEGRITKAE | EEFQKAQKVF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEFNTDLQEE | LPSLWSRRVG | FYVNTFKNVS | SLEAKFHKEI | ALLCHKLYEV | MTKLGDQHAD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KAFTIQGAPS | DSGPLRIAKT | PSPPEEVSPL | PSPTASPNHM | LAPASPAPAR | PKSPTQLRKG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PPVPPLPKLT | PTKELQQENI | INLFDDNFVP | EINVTTPSQN | EIPETKKVES | LLDLDFDPFK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEVVSTGVTH | SPMSQTLPWD | LWTTTSELVQ | PASSTAFNGF | AQDTTAFAVQ | SNENVTETLT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EAEEAPLGEL | KVEETPTAAV | VEKEAILAEP | DEPTEQAAES | IEAGDKETTG | IAEKESEVVS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AAGGAVAVED | SVVVAAGAGE | GAVRTEQEAA | AEGDKPQGEE | KDVDVSQEKV | SSIPSVVIEP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ASNNEGEGEE | HHVIMNESKD | AAAEMGTQGT | DSETSQIGSE | QKATEEIQTT | PSQDQPASAG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DTASDMPPGF | LFKVEVLHDF | EAANSDELNL | KRGDIVLVIP | SETTADQEAG | WLTGIKESEW |
| 670 | 680 | ||||
| LQYRDANSYK | GLFPENFTRH | LE |