P46975

PR
Gene name
stt-3
Protein name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3
Names
Oligosaccharyl transferase subunit stt-3
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_T12A2.2
EC number
2.4.99.18: Transferring other glycosyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-41 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P46975

Entry ID Method Resolution Chain Position Source
AF-P46975-F1 Predicted AlphaFoldDB

No variants for P46975

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P46975

No associated diseases with P46975

No regional properties for P46975

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P46975

Functions

Description
EC Number 2.4.99.18 Transferring other glycosyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
oligosaccharyltransferase complex A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected.

2 GO annotations of molecular function

Name Definition
dolichyl-diphosphooligosaccharide-protein glycotransferase activity Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine.
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
post-translational protein modification The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
protein N-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.
protein N-linked glycosylation via asparagine The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39007 STT3 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q2KJI2 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Bos taurus (Bovine) PR
P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Homo sapiens (Human) PR
Q8TCJ2 STT3B Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B Homo sapiens (Human) PR
P46978 Stt3a Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Mus musculus (Mouse) PR
Q3TDQ1 Stt3b Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B Mus musculus (Mouse) PR
Q7XQ88 STT3B Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B Oryza sativa subsp japonica (Rice) PR
Q93ZY3 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Arabidopsis thaliana (Mouse-ear cress) PR
Q9FX21 STT3B Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTSTTAARTA SSRVGATTLL TIVVLALAWF VGFASRLFAI VRFESIIHEF DPWFNYRATH
70 80 90 100 110 120
HMVQHGFYKF LNWFDERAWY PLGRIVGGTV YPGLMVTSGL IHWILDSLNF HVHIREVCVF
130 140 150 160 170 180
LAPTFSGLTA IATYLLTKEL WSPGAGLFAA CFIAISPGYT SRSVAGSYDN EGIAIFALQF
190 200 210 220 230 240
TYYLWVKSLK TGSIMWASLC ALSYFYMVSA WGGYVFIINL IPLHALALII MGRYSSRLFV
250 260 270 280 290 300
SYTSFYCLAT ILSMQVPFVG FQPVRTSEHM PAFGVFGLLQ IVALMHYARN RITRQQFMTL
310 320 330 340 350 360
FVGGLTILGA LSVVVYFALV WGGYVAPFSG RFYSLWDTGY AKIHIPIIAS VSEHQPTTWV
370 380 390 400 410 420
SFFFDLHITA AVFPVGLWYC IKKVNDERVF IILYAVSAVY FAGVMVRLML TLTPAVCVLA
430 440 450 460 470 480
GIGFSYTFEK YLKDEETKER SSSQSGTTKD EKLYDKAAKN VKSRNANDGD ESGVSSNVRT
490 500 510 520 530 540
IISIILVIFL LMFVVHATYV TSNAYSHPSV VLQSSTNNGD RIIMDDFREA YHWLRENTAD
550 560 570 580 590 600
DARVMSWWDY GYQIAGMANR TTLVDNNTWN NSHIALVGKA MSSNESAAYE IMTELDVDYI
610 620 630 640 650 660
LVIFGGVIGY SGDDINKFLW MVRIAQGEHP KDIREENYFT STGEYSTGAG ASETMLNCLM
670 680 690 700 710 720
YKMSYYRFGE TRVGYNQAGG FDRTRGYVIG KKDITLEYIE EAYTTENWLV RIYKRKKLPN
730 740 750
RPTVKSEEAT IPIKGKKATQ GKNKKGVIRP APTASKA