P46682
Gene name |
APL6 (YKS5, YGR261C, G9331) |
Protein name |
AP-3 complex subunit beta |
Names |
Adaptor-related protein complex 3 subunit beta, Beta-3-adaptin, Clathrin assembly protein complex 3 beta large chain, Clathrin assembly protein large beta chain |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR261C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P46682
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7P3X | EM | 910 A | B | 1-809 | PDB |
| 7P3Y | EM | 1010 A | B | 1-809 | PDB |
| 7P3Z | EM | 1050 A | B | 1-809 | PDB |
| AF-P46682-F1 | Predicted | AlphaFoldDB |
14 variants for P46682
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-1016201 | 186 | N>D | No | SGRP | |
| s07-1016091 | 222 | H>Q | No | SGRP | |
| s07-1016044 | 238 | K>R | No | SGRP | |
| s07-1015936 | 274 | P>L | No | SGRP | |
| s07-1015834 | 308 | C>Y | No | SGRP | |
| s07-1015756 | 334 | M>K | No | SGRP | |
| s07-1015499 | 420 | A>S | No | SGRP | |
| s07-1015153 | 535 | Q>P | No | SGRP | |
| s07-1015022 | 579 | P>S | No | SGRP | |
| s07-1014841 | 639 | S>N | No | SGRP | |
| s07-1014730 | 676 | N>S | No | SGRP | |
| s07-1014623 | 712 | S>P | No | SGRP | |
| s07-1014562 | 732 | N>I | No | SGRP | |
| s07-1014436 | 774 | S>N | No | SGRP |
No associated diseases with P46682
1 regional properties for P46682
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Clathrin/coatomer adaptor, adaptin-like, N-terminal | 40 - 621 | IPR002553 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| AP-3 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). |
| clathrin-coated vesicle membrane | The lipid bilayer surrounding a clathrin-coated vesicle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| Golgi to vacuole transport | The directed movement of substances from the Golgi to the vacuole. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| protein targeting to vacuole | The process of directing proteins towards the vacuole, usually using signals contained within the protein. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVDSIHRIAS | ALDTAKVITR | EAAAVATSKL | GESSYTYYSQ | NINPQQLVTL | LNSRNSREVR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DAMKRIISIM | ASDDDSIDVQ | LYFADVVKNI | TTNDTKVKRL | IHLYLLRFAE | NDPNLTLLSI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NSLQKSLSDS | NSELRCFALS | ALSDMKMSSL | APIILHTVKK | LVTDPSAMVR | GEVALAIIKL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YRAGKNDYHE | ELLDILKELM | ADTDPKVISC | AVLAYKECYA | DHLELLHGHF | RRYCRIIKQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DSWSQSYLIE | LLIKYCKQYL | PKPTVVDKSS | EGSPRSCPLP | DKYNEIEYPS | YEVVNDPDLD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LFLQSLNCLI | YSSNPTVILS | CCNALYQLAS | PLQMKNTKFI | EALVRTVTMT | ENQGNKEMLL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QAIHFLSILD | QTLFLPYTKK | FYVFPKDPIV | ASIWKIQILS | TLINESNVKE | IFKELKYYVA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SAHFPENVVI | MAVKSLSRCG | QLSTSWESHV | MKWLIDHMES | HNLSASVLDA | YVNVIRMLVQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KNPTKHLRII | FKLADLLTVQ | TSLADNARAG | IVWLFGEIAS | IEFKICPDVL | RRLIQNFSNE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GPETRCQILV | LSAKLLSYDI | DNFKQAQVTG | SEENNQNPPY | YDFSGSRISQ | MYNAVLYLAK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YDDEFDIRDR | ARMISSLFDS | GKYEIVSLLL | QAPKPTARSD | DFIVSARLET | HTPEIKEFFR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MLPWNTEITE | VGETGNDIRE | GAELKDYNKY | KKSFSSQSFI | TNNSARSFTS | SSNAKLTGIN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DGDSNSISGK | GNVNTFTSQN | GKKYRLQSLD | EFFSDIPERK | SKPRKIIKVV | EESSDEDEDE |
| 790 | 800 | ||||
| SEESSDDDEY | SDSSLGTSSS | GTSSSHLEL |