P27351
Gene name |
APL1 (YAP80, YJR005W, J1422) |
Protein name |
AP-2 complex subunit beta |
Names |
Beta-2-adaptin, Beta-adaptin, Clathrin assembly protein complex 2 beta large chain, Clathrin assembly protein large beta chain |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YJR005W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P27351
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P27351-F1 | Predicted | AlphaFoldDB |
13 variants for P27351
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s10-446042 | 43 | A>T | No | SGRP | |
| s10-446078 | 55 | V>L | No | SGRP | |
| s10-446300 | 129 | A>T | No | SGRP | |
| s10-446685 | 257 | Y>S | No | SGRP | |
| s10-447105 | 397 | V>A | No | SGRP | |
| s10-447366 | 484 | S>N | No | SGRP | |
| s10-447426 | 504 | S>N | No | SGRP | |
| s10-447477 | 521 | I>T | No | SGRP | |
| s10-447546 | 544 | K>R | No | SGRP | |
| s10-447572 | 553 | T>S | No | SGRP | |
| s10-447800 | 629 | F>I | No | SGRP | |
| s10-447872 | 653 | A>T | No | SGRP | |
| s10-447945 | 677 | N>S | No | SGRP |
No associated diseases with P27351
No regional properties for P27351
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P27351 | |||
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| AP-2 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
| cellular bud neck | The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. |
| endocytic vesicle | A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| clathrin binding | Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDQKVFARY | KANEIVTDLQ | HFGVKKFKSN | ITRRKNALRK | IIANLVLGNY | GEMSVLFSEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKFWQIEDDL | EVKRICHEYI | RVIGALKPQQ | AREALPFIMD | DFKSRDEKLQ | IMALRTLVLV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PVKELSDQAF | DCIISLVNHK | SPPEQVTRTA | IYALLDLDEI | DHERVLGLSS | ILHDIVKAQS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSPEVIVAAL | HTLYSIHEKN | ANMEPFRIPL | ELAFDMLELL | PELNEWNKAT | VLEVLTTSVV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PQHYLDTHEM | IELALPYLQQ | VNTYVVLNSL | KFIMYLLNYV | DVIKETLAEK | LSNSVIALLD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPPELQFLVL | RNVILLLLSR | ESSLLRLDIS | YFFIEYNDPI | YIKDTKLECL | YLLANKETLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RILEELEQYA | TDIDIQMSRK | SVRAIGNLAV | KLDEDSVHDC | VAVLLDLLEF | GVDYVVQEII |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SVFRNILRKY | PNNFKANVTE | LVKHTEVVQE | PESKNAMIWI | ITQYSDVIPN | YLELFRVFSS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NMFSETLEVQ | FSILNSAIKF | FIRSPTKETE | ELCMDLLKGC | IDHENNPDLR | DKTLMYWRLL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SLTKTSRISN | AITFESLKSV | LDGELPLIEM | NTKLDPTVLE | ELELNIGTIV | SIYLKPVSHI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FRLNKTKLLP | QSPILNPNKD | LLPVVGNSFP | PTGANRDRQN | SESQSSTKSR | KTAMMDDYDK |
| 670 | 680 | 690 | |||
| PAEKINQLKG | KRKSSSNNPS | KLSRKPSTLL | RKLSMKRPFS |