P46286

PR
Gene name
RPL8A (EMB2296, RPL2, At2g18020, T27K22.11)
Protein name
60S ribosomal protein L8-1
Names
60S ribosomal protein L2, Protein EMBRYO DEFECTIVE 2296
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G18020
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P46286

Entry ID Method Resolution Chain Position Source
AF-P46286-F1 Predicted AlphaFoldDB

1 variants for P46286

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_7837920_G_A 179 M>I No 1000Genomes

No associated diseases with P46286

3 regional properties for P46286

Type Name Position InterPro Accession
domain Ribosomal Proteins L2, RNA binding domain 13 - 89 IPR022666
domain Ribosomal protein L2, C-terminal 96 - 231 IPR022669
conserved_site Ribosomal protein L2, conserved site 197 - 208 IPR022671

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytosolic large ribosomal subunit The large subunit of a ribosome located in the cytosol.
cytosolic ribosome A ribosome located in the cytosol.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
plant-type vacuole A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
polysomal ribosome A ribosome bound to mRNA that forms part of a polysome.
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

3 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA binding Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9XVF7 rpl-2 60S ribosomal protein L8 Caenorhabditis elegans PR
P0DKI4 PUX14 Putative plant UBX domain-containing protein 14 Arabidopsis thaliana (Mouse-ear cress) PR
Q42064 RPL8C 60S ribosomal protein L8-3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGRVIRAQRK GAGSVFKSHT HHRKGPAKFR SLDFGERNGY LKGVVTEIIH DPGRGAPLAR
70 80 90 100 110 120
VTFRHPFRFK KQKELFVAAE GMYTGQFLYC GKKATLVVGN VLPLRSIPEG AVVCNVEHHV
130 140 150 160 170 180
GDRGVLARAS GDYAIVIAHN PDSDTTRIKL PSGSKKIVPS GCRAMIGQVA GGGRTEKPML
190 200 210 220 230 240
KAGNAYHKYR VKRNSWPKVR GVAMNPVEHP HGGGNHQHIG HASTVRRDAP PGQKVGLIAA
250
RRTGRLRGQA AASAAKAD