P40541
PR
Gene name |
IRR1 (SCC3, YIL026C) |
Protein name |
Cohesin subunit SCC3 |
Names |
Irregular cell behavior protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YIL026C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P40541
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4UVJ | X-ray | 210 A | A/B | 674-1072 | PDB |
| 6H8Q | X-ray | 363 A | A/B | 1-1150 | PDB |
| AF-P40541-F1 | Predicted | AlphaFoldDB |
18 variants for P40541
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s09-307878 | 17 | I>T | No | SGRP | |
| s09-307777 | 51 | T>P | No | SGRP | |
| s09-307414 | 172 | I>L | No | SGRP | |
| s09-307248 | 227 | K>R | No | SGRP | |
| s09-306504 | 475 | T>M | No | SGRP | |
| s09-306115 | 605 | N>D | No | SGRP | |
| s09-306045 | 628 | S>T | No | SGRP | |
| s09-306035 | 631 | E>D | No | SGRP | |
| s09-305814 | 705 | S>T | No | SGRP | |
| s09-305749 | 727 | T>S | No | SGRP | |
| s09-305566 | 788 | K>E | No | SGRP | |
| s09-305475 | 818 | R>K | No | SGRP | |
| s09-305283 | 882 | E>V | No | SGRP | |
| s09-305238 | 897 | A>V | No | SGRP | |
| s09-305215 | 905 | T>A | No | SGRP | |
| s09-304998 | 977 | K>I | No | SGRP | |
| s09-304736 | 1064 | M>I | No | SGRP | |
| s09-304638 | 1097 | T>N | No | SGRP |
No associated diseases with P40541
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| chromosome, centromeric region | The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| cohesin complex | A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitotic cohesin complex | A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| establishment of meiotic sister chromatid cohesion | The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle. |
| establishment of mitotic sister chromatid cohesion | The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle. |
| mitotic sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. |
| protein acetylation | The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic |
| sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UJ98 | STAG3 | Cohesin subunit SA-3 | Homo sapiens (Human) | PR |
| Q8N3U4 | STAG2 | Cohesin subunit SA-2 | Homo sapiens (Human) | PR |
| O70576 | Stag3 | Cohesin subunit SA-3 | Mus musculus (Mouse) | PR |
| O35638 | Stag2 | Cohesin subunit SA-2 | Mus musculus (Mouse) | PR |
| Q99M76 | Stag3 | Cohesin subunit SA-3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTAVRRSTRI | RTKSQVIEED | YDDEQNTSAQ | HVESDKITAK | TQHEEEEEQD | TGESEESSSE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDYEDQDDDD | YVDTATAKRK | SRKRKPKSAS | NTSSKRQKKK | PTSAQKSAVS | HAPAYHRSKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DQDQYLEIAK | DFQPTELFDI | LSTSEDVSIE | ELLREWLETY | SENRDKFLQE | FINLLLNCCG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVARVEDHDV | HSNESSNETI | GEIQLLFQRQ | KLHEFYLLIS | KENKKRKNFK | MGPLYQNFAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FMTKLLEVAN | DLQLLYVESD | EDDTQIVTGN | LVLDLLTWLS | SFSVCKIRCF | RYISTLTLYL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FQDYLTQQAV | NLEKNYLAKL | SKQLSLEEKK | KRPNNKTLEK | LESTIAETQG | SKVVIDSIID |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NIVKLCFVHR | YKDVSDLIRS | ESMLHLSIWI | KNYPEYFLKV | TFLKYFGWLL | SDNSVSVRLQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VTKILPHLII | QNHNSKSTDN | SAIRQVFERF | KTKILEVAIR | DVNLDVRIHS | IQVLTEASSL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GYLDDSEILI | ISSLMFDEEF | DPFKTSSFNK | RSKFLSTVAK | FLARVIKEKF | DEFIKTHEDL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PKEVDGLEVG | PVVQVGIFIK | ILNDSLIYHL | KDCAEVDSRT | KIRMLTQAAE | FLSPYISTHL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KTICNLLISD | TESNELIQKL | QNSANNNSDD | EDVDDEELDI | TPLFPIDRNS | TILYLNVFHG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LCAGANNPKI | QTKDSVKEIV | LPLFYDLLNA | ASIESADILC | PLLESFITFS | LDDWISIGYE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TELKKITDKT | IKAFMDSTIG | NSKVDMKYDI | FAKFIHHIHH | FEKKELQEKF | LNQIATLKIH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LKKFLQEKMD | PNNSRDDYKD | LTCSLYELYI | NKLTILGRDY | PIEVDEELLQ | LFLNNFVSRI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PIMFQDFDDS | TAQEINFKML | VLLATWNLEK | WREIIEKVRD | YENSISKDLR | SVWKPIAAII |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GRLNTLVISL | AATNETFENI | NSLFYLKWSA | CTSLMDIIVA | IKIFELKLPA | DATTWRYSMS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EQFPFYLHDN | ASKVLLKIFL | YLESLFAKQV | DVQLERVADE | DANLNDLPET | GFFENIETEF |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LLFTVKLKGL | MKLNILDERF | ASRVALNKEK | LGPLFKKIVD | DTIMENPEPN | KKNIQKAKSN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| QTQREKAPLQ | PNSERETDHA | NTENNDPDIP | MTIDLEPIEE | SSQNNSELAP | IEEHPTVVDA |
| IDNSDEITQD |