O35638
PR
Gene name |
Stag2 (Sa2, Sap2) |
Protein name |
Cohesin subunit SA-2 |
Names |
SCC3 homolog 2, Stromal antigen 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20843 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35638
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35638-F1 | Predicted | AlphaFoldDB |
50 variants for O35638
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3410012705 | 30 | I>M | No | EVA | |
| rs3409860608 | 38 | G>A | No | EVA | |
| rs3410220178 | 42 | T>S | No | EVA | |
| rs3409594685 | 55 | K>N | No | EVA | |
| rs3389551352 | 68 | N>H | No | EVA | |
| rs3407873093 | 137 | R>* | No | EVA | |
| rs3410221535 | 145 | I>L | No | EVA | |
| rs3409595741 | 158 | D>E | No | EVA | |
| rs3410083121 | 158 | D>Y | No | EVA | |
| rs3410083135 | 159 | Y>S | No | EVA | |
| rs3409862024 | 162 | T>N | No | EVA | |
| rs3389551867 | 166 | P>R | No | EVA | |
| rs3389537484 | 201 | I>F | No | EVA | |
| rs3407873055 | 202 | S>T | No | EVA | |
| rs3389537430 | 204 | L>P | No | EVA | |
| rs3413085868 | 214 | A>E | No | EVA | |
| rs3410221492 | 214 | A>P | No | EVA | |
| rs3389573266 | 218 | T>I | No | EVA | |
| rs3389551860 | 254 | K>I | No | EVA | |
| rs3409971125 | 271 | R>L | No | EVA | |
| rs3408785019 | 272 | K>N | No | EVA | |
| rs3389558653 | 313 | G>V | No | EVA | |
| rs3389551358 | 315 | W>* | No | EVA | |
| rs3389554453 | 327 | S>R | No | EVA | |
| rs3389554408 | 357 | N>Y | No | EVA | |
| rs3389537424 | 428 | A>S | No | EVA | |
| rs3389525105 | 434 | K>I | No | EVA | |
| rs3389561025 | 450 | R>G | No | EVA | |
| rs3389558267 | 471 | S>N | No | EVA | |
| rs3389554400 | 524 | I>K | No | EVA | |
| rs3389568792 | 531 | Q>P | No | EVA | |
| rs3409595719 | 539 | V>A | No | EVA | |
| rs3410112570 | 539 | V>M | No | EVA | |
| rs3409235279 | 541 | R>G | No | EVA | |
| rs3409862076 | 542 | G>W | No | EVA | |
| rs3409862072 | 583 | E>A | No | EVA | |
| rs3409971132 | 583 | E>K | No | EVA | |
| rs3409595768 | 588 | L>F | No | EVA | |
| rs3410221511 | 640 | C>F | No | EVA | |
| rs3409595766 | 640 | C>K | No | EVA | |
| rs3389525168 | 685 | Y>F | No | EVA | |
| rs3409595718 | 705 | K>M | No | EVA | |
| rs3389556538 | 717 | K>N | No | EVA | |
| rs3409235071 | 721 | E>S | No | EVA | |
| rs3389573206 | 726 | P>H | No | EVA | |
| rs3389551887 | 959 | F>V | No | EVA | |
| rs3389573211 | 988 | Q>L | No | EVA | |
| rs3410014191 | 1114 | V>A | No | EVA | |
| rs3408786793 | 1156 | N>S | No | EVA | |
| rs3389558575 | 1183 | E>D | No | EVA |
No associated diseases with O35638
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| chromosome, centromeric region | The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| cohesin complex | A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| mitotic spindle pole | Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
| nuclear matrix | The dense fibrillar network lying on the inner side of the nuclear membrane. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| mitotic spindle assembly | Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. |
| sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other. |
| stem cell population maintenance | The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40541 | IRR1 | Cohesin subunit SCC3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9UJ98 | STAG3 | Cohesin subunit SA-3 | Homo sapiens (Human) | PR |
| Q8N3U4 | STAG2 | Cohesin subunit SA-2 | Homo sapiens (Human) | PR |
| O70576 | Stag3 | Cohesin subunit SA-3 | Mus musculus (Mouse) | PR |
| Q99M76 | Stag3 | Cohesin subunit SA-3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIAAPEIPTD | FNLLQESETH | FSSDTDFEDI | EGKNQKQGKG | KTCKKGKKGP | AEKGKSGNGG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GKPPSGSNRM | NGHHQQNGVE | NMMLFEVVKM | GKSAMQSVVD | DWIESYKHDR | DIALLDLINF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FIQCSGCKGV | VTAEMFRHMQ | NSEIIRKMTE | EFDEDSGDYP | LTMAGPQWKK | FKSSFCEFIG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLVRQCQYSI | IYDEYMMDTV | ISLLTGLSDS | QVRAFRHTST | LAAMKLMTAL | VNVALNLSIN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MDNTQRQYEA | ERNKMIGKRA | NERLELLLQK | RKELQENQDE | IENMMNAIFK | GVFVHRYRDA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IAEIRAICIE | EIGIWMKMYS | DAFLNDSYLK | YVGWTMHDKQ | GEVRLKCLTA | LQGLYYNKEL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NSKLELFTSR | FKDRIVSMTL | DKEYDVAVQA | IKLLTLVLQS | SEEVLTAEDC | ENVYHLVYSA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HRPVAVAAGE | FLYKKLFSRR | DPEEDGLMKR | RGRQGPNANL | VKTLVFFFLE | SELHEHAAYL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VDSMWDCATE | LLKDWECMNS | LLLEEPLSGE | EALTDRQESA | LIEIMLCTIR | QAAECHPPVG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RGTGKRVLTA | KEKKTQLDDR | TRITELFAVA | LPQLLAKYSV | DAEKVTNLLQ | LPQYFDLEIY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TTGRLEKHLD | ALLRQIRNIV | EKHTDTDVLE | ACSKTYHALC | NEEFTIFNRV | DISRSQLIDE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LADKFNRLLE | DFLQEGEEPD | EDDAYQVLST | LKRITAFHNA | HDLSKWDLFA | CNYKLLKTGI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ENGDMPEQIV | IHALQCAHYV | ILWQLAKITE | STSTKEDLLR | LKKQMRVFCQ | ICQHYLTNVN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TTVKEQAFTI | LCDILMIFSH | QIMSGGRDML | EPLVYTPDSS | LQSELLSFIL | DHVFIEQDDD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SNSADGQQED | EASKIEALHK | RRNLLAAFCK | LIVYTVVEMN | TAADIFKQYM | KYYNDYGDII |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KETMSKTRQI | DKIQCAKTLI | LSLQQLFNEM | IQENGYNFDR | SSSTFSGIKE | LARRFALTFG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LDQLKTREAI | AMLHKDGIEF | AFKEPNPQGE | SHPPLNLAFL | DILSEFSSKL | LRQDKRTVYV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| YLEKFMTFQM | SLRREDVWLP | LMSYRNSLLA | GGDDDTMSVI | SGMSSRGSTV | RSKKSKPSTG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KRKVVEGMQL | ALPEESSSSD | SMWLSREQTL | HTPVMMQTPQ | LTSTIMREPK | RLRPEDSFMS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VYPMQAEHHQ | TPLDYNRRGT | SLMEDDEEPI | VEDVMMSSEG | RIEDLNEGMD | FDTMDIDLPP |
| 1210 | 1220 | 1230 | |||
| SKNRRERTEL | KPDFFDPASI | MDESVLGVSM | F |