O70576
PR
Gene name |
Stag3 |
Protein name |
Cohesin subunit SA-3 |
Names |
SCC3 homolog 3, Stromal antigen 3, Stromalin-3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:50878 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O70576
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O70576-F1 | Predicted | AlphaFoldDB |
73 variants for O70576
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388805336 | 31 | Q>* | No | EVA | |
| rs224718698 | 44 | C>S | No | EVA | |
| rs3388804120 | 61 | N>T | No | EVA | |
| rs3388805403 | 67 | E>D | No | EVA | |
| rs3388797836 | 68 | D>A | No | EVA | |
| rs3388803178 | 75 | K>* | No | EVA | |
| rs231887894 | 100 | S>P | No | EVA | |
| rs3388807475 | 105 | K>N | No | EVA | |
| rs252092298 | 135 | D>E | No | EVA | |
| rs3388809032 | 140 | D>Y | No | EVA | |
| rs215434427 | 149 | I>V | No | EVA | |
| rs3396336031 | 152 | F>Y | No | EVA | |
| rs3388804081 | 162 | V>L | No | EVA | |
| rs3396337749 | 184 | N>KLFR* | No | EVA | |
| rs3388795393 | 186 | D>N | No | EVA | |
| rs3388807505 | 242 | Q>P | No | EVA | |
| rs3388774242 | 243 | V>I | No | EVA | |
| rs3388788389 | 276 | Q>K | No | EVA | |
| rs252479499 | 305 | F>L | No | EVA | |
| rs226461449 | 306 | Q>R | No | EVA | |
| rs255769017 | 321 | R>K | No | EVA | |
| rs221485590 | 321 | R>S | No | EVA | |
| rs3388805383 | 323 | V>I | No | EVA | |
| rs3388804112 | 402 | F>L | No | EVA | |
| rs3388807503 | 412 | D>N | No | EVA | |
| rs3388801941 | 431 | N>I | No | EVA | |
| rs3388803189 | 461 | E>A | No | EVA | |
| rs249701404 | 474 | A>P | No | EVA | |
| rs3388805404 | 528 | E>G | No | EVA | |
| rs3412732023 | 571 | T>I | No | EVA | |
| rs247472890 | 589 | M>V | No | EVA | |
| rs3396039707 | 609 | D>A | No | EVA | |
| rs3396127392 | 609 | D>Y | No | EVA | |
| rs3388804095 | 617 | L>P | No | EVA | |
| rs3388785690 | 619 | L>P | No | EVA | |
| rs3388774270 | 620 | L>F | No | EVA | |
| rs3388807538 | 621 | S>T | No | EVA | |
| rs3388796597 | 622 | Y>H | No | EVA | |
| rs3396440958 | 641 | L>Q | No | EVA | |
| rs3396264410 | 642 | Q>H | No | EVA | |
| rs3396326397 | 643 | Q>H | No | EVA | |
| rs3396245142 | 645 | Q>L | No | EVA | |
| rs3388804080 | 646 | E>D | No | EVA | |
| rs3396440927 | 647 | V>L | No | EVA | |
| rs3396261650 | 648 | V>L | No | EVA | |
| rs3396326426 | 649 | V>E | No | EVA | |
| rs3396440941 | 649 | V>L | No | EVA | |
| rs3388799066 | 724 | F>C | No | EVA | |
| rs3388807460 | 739 | C>R | No | EVA | |
| rs3388805414 | 751 | E>* | No | EVA | |
| rs3388804170 | 770 | W>* | No | EVA | |
| rs3396337719 | 771 | T>I | No | EVA | |
| rs3396127376 | 775 | I>T | No | EVA | |
| rs3396337708 | 776 | S>* | No | EVA | |
| rs3396202436 | 778 | S>Y | No | EVA | |
| rs3396336037 | 781 | H>D | No | EVA | |
| rs3388774201 | 788 | K>* | No | EVA | |
| rs3388796624 | 805 | V>M | No | EVA | |
| rs3388795363 | 810 | Q>H | No | EVA | |
| rs3388795322 | 879 | E>Q | No | EVA | |
| rs3395897181 | 913 | N>I | No | EVA | |
| rs3388803890 | 943 | L>P | No | EVA | |
| rs3388803166 | 965 | L>P | No | EVA | |
| rs3388796620 | 991 | D>N | No | EVA | |
| rs3388808994 | 1050 | Q>* | No | EVA | |
| rs3388803903 | 1070 | L>F | No | EVA | |
| rs236926910 | 1072 | P>S | No | EVA | |
| rs36692794 | 1075 | I>N | No | EVA | |
| rs3388774276 | 1093 | E>G | No | EVA | |
| rs3388804140 | 1118 | T>S | No | EVA | |
| rs3388795344 | 1140 | K>N | No | EVA | |
| rs3388795367 | 1162 | T>S | No | EVA | |
| rs3388795352 | 1223 | S>C | No | EVA |
No associated diseases with O70576
Functions
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| chromosome, centromeric region | The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| cohesin complex | A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). |
| condensed nuclear chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. |
| lateral element | A proteinaceous core found between sister chromatids during meiotic prophase. |
| male germ cell nucleus | The nucleus of a male germ cell, a reproductive cell in males. |
| meiotic cohesin complex | A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| synaptonemal complex | A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element. |
| transverse filament | A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| establishment of meiotic sister chromatid cohesion | The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle. |
| female meiosis sister chromatid cohesion | The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female. |
| homologous chromosome pairing at meiosis | The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. |
| male meiosis sister chromatid cohesion | The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male. |
| protein localization to chromosome | Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. |
| sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40541 | IRR1 | Cohesin subunit SCC3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q8N3U4 | STAG2 | Cohesin subunit SA-2 | Homo sapiens (Human) | PR |
| Q9UJ98 | STAG3 | Cohesin subunit SA-3 | Homo sapiens (Human) | PR |
| O35638 | Stag2 | Cohesin subunit SA-2 | Mus musculus (Mouse) | PR |
| Q99M76 | Stag3 | Cohesin subunit SA-3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPTLWSPSTQ | HHGSSSGSES | SPLQKSVRRA | QMALSPCSSS | ILPCDDRDSQ | GTAEWDSPST |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NEDSDFEDSL | RRNVKKRAAK | QPPKAVPAAK | HRKKQSRIVS | SGNGKNESVP | STNYLFDAVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AARSCMQSLV | DEWLDNYKQD | ENAGFLELIN | FFIRACGCKS | TVTPEMFKTM | SNSEIIQHLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEFNEDSGDY | PLTAPGPSWK | KFQGSFCEFV | KTLVYQCQYS | LLYDGFPMDD | LISLLIGLSD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SQVRAFRHTS | TLAAMKLMTS | LVKVALQLSL | HKDNNQRQYE | AERNKGPEQR | APERLESLLE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KRKEFQENQE | DIEGMMNAIF | RGVFVHRYRD | ILPEIRAICI | EEIGYWMQSY | STSFLNDSYL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KYIGWTLHDK | HKEVRLKCVK | ALAGLYSNQE | LSLRMELFTN | RFKDRMVSMV | MDRECEVAVE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AIRLLTLILK | NMEGVLTSAD | CEKIYSIVYI | SNRAMASSAG | EFVYWKIFHP | ECGAKAVSDR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ERRRSPQAQK | TFIYLLLAFF | MESEHHNHAA | YLVDSLWDCA | GSYLKDWESL | TNLLLQKDQN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LGDMQERMLI | EILVSSARQA | AEGHPPVGRI | TGKKSLTAKE | RKLQAYDKMK | LAEHLIPLLP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QLLAKFSADA | ENVAPLLQLL | SYFDLSIYCT | QRLEKHLELL | LQQLQEVVVK | HVEPEVLEAA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AHALYLLCKP | EFTFFSRVDF | ARSQLVDFLT | DRFQQELDDL | MQSSFLDEDE | VYSLTATLKR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LSAFYNAHDL | TRWEISEPCS | RLLRKAVDTG | EVPHQVILPA | LTLVYFSILW | TVTHISESTS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| HKQLMSLKKR | MVAFCELCQS | CLSDVDPEIQ | EQAFVLLSDL | LLIFSPQMIV | GGRDFLRPLV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FFPEATLQSE | LASFLMDHVF | LQPGELGNGQ | SQEDHVQIEL | LHQRRRLLAG | FCKLLLYGVL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ELDAASDVFK | HYNKFYEDYG | DIIKETLTRA | RQIDRCQCSR | ILLLSLKQLY | TELIQEQGPQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GLTELPAFIE | MRDLARRFAL | SFGPQQLHNR | DLVVMLHKEG | IKFSLSELPP | AGSSHEPPNL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AFLELLSEFS | PRLFHQDKRL | LLSYLEKCLQ | RVSKAPNHPW | GPVTTYCHSL | HPLEITAEAS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| PRGPPHSKKR | CVEGPCRPQE | EESSSQEESL | QLNSGPTTPT | LTSTAVKRKQ | SLRTVGKKQK |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GRPGPGPGPG | PELICSQQLL | GTQRLKMSSA | PCFQIRCDPS | GSGLGKQLTR | LSLMEEDEEE |
| 1210 | 1220 | 1230 | |||
| ELRLLDEEWQ | RGDKMLHSPS | SPSEHGLDLL | DTTELNMEDF |