P39535

PR
Gene name
PHO90 (YJL198W, J0336)
Protein name
Low-affinity phosphate transporter PHO90
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJL198W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-243 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P39535

Entry ID Method Resolution Chain Position Source
AF-P39535-F1 Predicted AlphaFoldDB

11 variants for P39535

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-60958 39 V>A No SGRP
s10-60978 46 F>I No SGRP
s10-61390 183 D>G No SGRP
s10-61544 234 I>M No SGRP
s10-61707 289 S>T No SGRP
s10-61735 298 A>V No SGRP
s10-61813 324 R>Q No SGRP
s10-62043 401 N>Y No SGRP
s10-62856 672 T>A No SGRP
s10-62901 687 I>V No SGRP
s10-63278 812 L>F No SGRP

No associated diseases with P39535

2 regional properties for P39535

Type Name Position InterPro Accession
domain PiggyBac transposable element-derived protein 103 - 468 IPR029526
domain PiggyBac transposable element-derived protein 4, C-terminal zinc-ribbon 539 - 575 IPR032718

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
inorganic phosphate transmembrane transporter activity Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.

4 GO annotations of biological process

Name Definition
anion transmembrane transport The process in which an anion is transported across a membrane.
phosphate ion transport The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
polyphosphate metabolic process The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid.
regulation of phosphate transmembrane transport Any process that modulates the frequency, rate or extent of phosphate transmembrane transport.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P25360 PHO87 Inorganic phosphate transporter PHO87 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P27514 PHO91 Low-affinity phosphate transporter PHO91 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MRFSHFLKYN AVPEWQNHYM DYSELKNLIY TLQTDELQVG DNEEGFGAGK SSNITDRFKN
70 80 90 100 110 120
KFSFKNAKED TSSGMNKDAG IVEETIELRE LPTAQTVAAK PSPFRRMKEK IFYKRRSSSA
130 140 150 160 170 180
SSVSSTANEN LQLDTYDTFV GDLTAEKQKV DDFYKRTEAK FYDKFDALVK DLKKIGVIEY
190 200 210 220 230 240
DIDDDTLFNE PIASTNDEVP PLDLDDDEDD DEFYDDQSNI EDNTALLHHS QYNIKSQKKS
250 260 270 280 290 300
LLKKSIVNLY IDLCQLKSFI ELNRIGFAKI TKKSDKVLHL NTRTELIESE QFFKDTYAFQ
310 320 330 340 350 360
AETIELLNSK ISQLVTFYAR ITDRPHNISH SKQELKSYLH DHIVWERSNT WKDMLGLLSQ
370 380 390 400 410 420
ADELTPKETE YNANKLVGKL DLEYYRWPLP RPINLKFTSI NNVALPKLFF TKKAYKIYFI
430 440 450 460 470 480
ILVTGLLLGI KTFNDAAQHR CMALVECVAF LWASEAIPLH ITAFLVPLLV VLFKVLKTSD
490 500 510 520 530 540
GAIMSAASAS SEILAAMWSS TIMILLAGFT LGEVLAQYNI AKVLASWLLA FAGCKPRNVL
550 560 570 580 590 600
LMAMCVVFFL SMWISNVAAP VLTYSLLSPL LDAMDADSPF AQALVLGVAL AANIGGMSSP
610 620 630 640 650 660
ISSPQNIISM SYLKPYGIGW GQFFAVALPS GILAMLLVWI LLFTTFKMNK TKLEKFKPIK
670 680 690 700 710 720
TKFTVKQYYI ITVTVATILL WCVESQIEGA FGSSGQIAII PIVLFFGTGL LSTQDLNAFP
730 740 750 760 770 780
WSIVILAMGG IALGKAVSSS GLLSTIAKAL QKKIENDGVF AILCIFGILM LVVGTFVSHT
790 800 810 820 830 840
VSAIIIIPLV QEVGDKLGNP KAAPILVFGC ALLSSCGMGL ASSGFPNVTA ISKVDRKGDR
850 860 870 880
YLSVMTFLTR GVPASILAFL CVITLGYGIM ASVVKGNATS A