P27514
Gene name |
PHO91 (YNR013C, N2052) |
Protein name |
Low-affinity phosphate transporter PHO91 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YNR013C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P27514
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P27514-F1 | Predicted | AlphaFoldDB |
9 variants for P27514
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s14-651579 | 46 | V>M | No | SGRP | |
| s14-651575 | 47 | E>G | No | SGRP | |
| s14-650843 | 291 | T>M | No | SGRP | |
| s14-650760 | 319 | D>Y | No | SGRP | |
| s14-650573 | 381 | P>R | No | SGRP | |
| s14-650570 | 382 | N>S | No | SGRP | |
| s14-650443 | 424 | M>I | No | SGRP | |
| s14-649816 | 633 | D>E | No | SGRP | |
| s14-649812 | 635 | S>P | No | SGRP |
No associated diseases with P27514
No regional properties for P27514
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P27514 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| vacuole-mitochondrion membrane contact site | A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glycerol-3-phosphate transmembrane transporter activity | Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol. |
| inorganic phosphate transmembrane transporter activity | Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| anion transmembrane transport | The process in which an anion is transported across a membrane. |
| glycerol-3-phosphate transmembrane transport | The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol. |
| phosphate ion transport | The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| polyphosphate metabolic process | The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid. |
| regulation of phosphate transmembrane transport | Any process that modulates the frequency, rate or extent of phosphate transmembrane transport. |
2 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P25360 | PHO87 | Inorganic phosphate transporter PHO87 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P39535 | PHO90 | Low-affinity phosphate transporter PHO90 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKFSHSLQFN | SVPEWSTKYL | AYSQLKKLIY | SLQKDKLYSN | NKHHVVEPHD | ANDENLPLLA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DASPDDQFYI | SKFVAALNQE | LKKIDKFYIS | QETGLIANYN | ELKDDVMELE | NTNKATQLFN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QQQQHQLQSV | ARNRKSKSQQ | RQRRFSSVSS | TDSNPSLTDM | SIDSAPVIHT | QVSNTTNNGN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SMQNLASASV | SLSNSNPVYL | SPFTQHRLSL | KKRLISIYTQ | LSELKDFIEL | NQTGFSKICK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KFDKSLNTNL | KQNYLNYIKF | HSHVFNPATI | NRIQHHITET | ILTYASLNKG | TRRPSNTFNL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DADRINNDEN | SSGNEEDEDG | NRQEVLDFQD | AERELSSHLR | DHVVWERNTV | WKDMMNLERK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YQSAKTDNKK | FSKLSSSQLR | PNANITESMA | MSSGGAGIIA | PSTDSLTFRE | LMHLPPKQWL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QFIMGQTSLL | KFLLITSCFI | ALLTFNLTPF | TQDSLQKNCF | AILIYASLLW | ATETIPLFVT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SLMIPLLIVV | FPVIKDPITS | QPMSPRDSSQ | FILSTMWSSV | IMLLLGGFTL | AAALSKYNIA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KVLSTHILAS | AGTNPHFILL | TNMFVALFVS | MWVSNVAAPV | LCYSIVQPLL | RTLPRNCSYA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KALILGIALA | SNIGGMSSPI | ASPQNIFSIG | IMDPSPSWAE | WFMIALPVCF | ICVMAIWVLL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IITFPPEPNV | KILQLHPSRD | PFTLKQWFVT | LVCIITIVLW | CLSNQISGIF | GEMGIISIIP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IVVFFGTGLL | TSDDFNNFMW | TIVVLAMGGT | TLGKAVSSSG | LLSTMAQLIK | AQVEHEPIFI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IVLIFGLVIL | VMATFVSHTV | AAMIIVPLMS | EIGSNLPSGD | HSRLLIVIAA | LLCSSAMGLP |
| 850 | 860 | 870 | 880 | 890 | |
| TSGFPNVTAI | SMIDEVGDRY | LTVGTFITRG | VPASLLSYAA | IVTVGYGILK | VMGF |