P38979

PR
Gene name
sta
Protein name
40S ribosomal protein SA
Names
K14, Laminin receptor homolog, Protein stubarista
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG14792
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-80 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P38979

Entry ID Method Resolution Chain Position Source
4V6W EM 600 A AA 1-270 PDB
6XU6 EM 350 A AA 6-223 PDB
6XU7 EM 490 A AA 6-223 PDB
6XU8 EM 300 A AA 6-223 PDB
AF-P38979-F1 Predicted AlphaFoldDB

No variants for P38979

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P38979

No associated diseases with P38979

4 regional properties for P38979

Type Name Position InterPro Accession
domain Ras-like guanine nucleotide exchange factor, N-terminal 488 - 623 IPR000651
domain SH3 domain 1 - 60 IPR001452
domain Ras guanine-nucleotide exchange factors catalytic domain 659 - 895 IPR001895
conserved_site Ras guanine-nucleotide exchange factor, conserved site 811 - 852 IPR019804

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • May associate with nascent RNP complexes within the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosolic ribosome A ribosome located in the cytosol.
cytosolic small ribosomal subunit The small subunit of a ribosome located in the cytosol.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.

2 GO annotations of molecular function

Name Definition
ribosome binding Binding to a ribosome.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

3 GO annotations of biological process

Name Definition
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
ribosomal small subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P46654 RPS0B 40S ribosomal protein S0-B Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P32905 RPS0A 40S ribosomal protein S0-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P46769 rps-0 40S ribosomal protein SA Caenorhabditis elegans PR
10 20 30 40 50 60
MSGGLDILSL KEDDITKMLV ATTHLGSENV NFQMEQYVYK RRADGVNILN LGKTWEKLQL
70 80 90 100 110 120
AARAIVAIDN PSDIFVISSR PIGQRAVLKF AKYTDTTPIA GRFTPGAFTN QIQPAFREPR
130 140 150 160 170 180
LLVVTDPNTD HQPIMEASYV NIPVIAFTNT DSPLRYIDIA IPCNNKSAHS IGLMWWLLAR
190 200 210 220 230 240
EVLRLRGTIS RSVEWPVVVD LFFYRDPEEA EKEEAAAKEL LPPPKIEEAV DHPVEETTNW
250 260
ADEVAAETVG GVEDWNEDTV KTSWGSDGQF