P38630

PR
Gene name
RFC1 (CDC44, YOR217W, YOR50-7)
Protein name
Replication factor C subunit 1
Names
Replication factor C1, Activator 1 95 kDa subunit, Cell division control protein 44
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOR217W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-177 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

26 structures for P38630

Entry ID Method Resolution Chain Position Source
1SXJ X-ray 285 A A 295-785 PDB
7TFH EM 309 A A 1-861 PDB
7TFI EM 341 A A 1-861 PDB
7TFJ EM 330 A A 1-861 PDB
7TFK EM 325 A A 1-861 PDB
7TFL EM 333 A A 1-861 PDB
7THJ EM 380 A A 1-861 PDB
7THV EM 400 A A 1-861 PDB
7TI8 EM 350 A A 1-861 PDB
7TIB EM 340 A A 1-861 PDB
7TIC EM 390 A A 1-861 PDB
7TID EM 330 A A 1-861 PDB
7TKU EM 400 A A 1-861 PDB
7U19 EM 370 A A 1-861 PDB
7U1A EM 330 A A 1-861 PDB
7U1P EM 300 A A 1-861 PDB
8DQX EM 210 A A 1-861 PDB
8DQZ EM 292 A A 1-861 PDB
8DR0 EM 242 A A 1-861 PDB
8DR1 EM 214 A A 1-861 PDB
8DR3 EM 220 A A 1-861 PDB
8DR4 EM 245 A A 1-861 PDB
8DR5 EM 276 A A 1-861 PDB
8DR6 EM 239 A A 1-861 PDB
8DR7 EM 270 A A 1-861 PDB
AF-P38630-F1 Predicted AlphaFoldDB

22 variants for P38630

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-749380 27 G>C No SGRP
s15-749609 103 N>S No SGRP
s15-749732 144 V>A No SGRP
s15-749764 155 P>S No SGRP
s15-749803 168 V>I No SGRP
s15-750145 282 G>S No SGRP
s15-750184 295 D>N No SGRP
s15-750221 307 L>P No SGRP
s15-750301 334 S>G No SGRP
s15-750397 366 V>I No SGRP
s15-750685 462 K>* No SGRP
s15-750687 462 K>N No SGRP
s15-750786 495 K>N No SGRP
s15-750971 557 K>R No SGRP
s15-751063 588 T>A No SGRP
s15-751145 615 A>D No SGRP
s15-751266 655 K>N No SGRP
s15-751331 677 A>G No SGRP
s15-751397 699 I>T No SGRP
s15-751477 726 S>A No SGRP
s15-751858 853 G>C No SGRP
s15-751858 853 G>S No SGRP

No associated diseases with P38630

4 regional properties for P38630

Type Name Position InterPro Accession
domain BRCT domain 153 - 233 IPR001357
domain AAA+ ATPase domain 345 - 479 IPR003593
domain ATPase, AAA-type, core 350 - 449 IPR003959
domain DNA replication factor RFC1, C-terminal 621 - 776 IPR013725

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
DNA replication factor C complex A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA clamp loader activity Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis.

6 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
leading strand elongation The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork.
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P49956 CTF18 Chromosome transmission fidelity protein 18 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P35251 RFC1 Replication factor C subunit 1 Homo sapiens (Human) PR
P35601 Rfc1 Replication factor C subunit 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MVNISDFFGK NKKSVRSSTS RPTRQVGSSK PEVIDLDTES DQESTNKTPK KMPVSNVIDV
70 80 90 100 110 120
SETPEGEKKL PLPAKRKASS PTVKPASSKK TKPSSKSSDS ASNITAQDVL DKIPSLDLSN
130 140 150 160 170 180
VHVKENAKFD FKSANSNADP DEIVSEIGSF PEGKPNCLLG LTIVFTGVLP TLERGASEAL
190 200 210 220 230 240
AKRYGARVTK SISSKTSVVV LGDEAGPKKL EKIKQLKIKA IDEEGFKQLI AGMPAEGGDG
250 260 270 280 290 300
EAAEKARRKL EEQHNIATKE AELLVKKEEE RSKKLAATRV SGGHLERDNV VREEDKLWTV
310 320 330 340 350 360
KYAPTNLQQV CGNKGSVMKL KNWLANWENS KKNSFKHAGK DGSGVFRAAM LYGPPGIGKT
370 380 390 400 410 420
TAAHLVAQEL GYDILEQNAS DVRSKTLLNA GVKNALDNMS VVGYFKHNEE AQNLNGKHFV
430 440 450 460 470 480
IIMDEVDGMS GGDRGGVGQL AQFCRKTSTP LILICNERNL PKMRPFDRVC LDIQFRRPDA
490 500 510 520 530 540
NSIKSRLMTI AIREKFKLDP NVIDRLIQTT RGDIRQVINL LSTISTTTKT INHENINEIS
550 560 570 580 590 600
KAWEKNIALK PFDIAHKMLD GQIYSDIGSR NFTLNDKIAL YFDDFDFTPL MIQENYLSTR
610 620 630 640 650 660
PSVLKPGQSH LEAVAEAANC ISLGDIVEKK IRSSEQLWSL LPLHAVLSSV YPASKVAGHM
670 680 690 700 710 720
AGRINFTAWL GQNSKSAKYY RLLQEIHYHT RLGTSTDKIG LRLDYLPTFR KRLLDPFLKQ
730 740 750 760 770 780
GADAISSVIE VMDDYYLTKE DWDSIMEFFV GPDVTTAIIK KIPATVKSGF TRKYNSMTHP
790 800 810 820 830 840
VAIYRTGSTI GGGGVGTSTS TPDFEDVVDA DDNPVPADDE ETQDSSTDLK KDKLIKQKAK
850 860
PTKRKTATSK PGGSKKRKTK A