P38121
Gene name |
POL12 (YBL035C, YBL0414) |
Protein name |
DNA polymerase alpha subunit B |
Names |
DNA polymerase I subunit B, DNA polymerase alpha:primase complex p86 subunit, Pol alpha-primase complex p86 subunit, DNA polymerase-primase complex p74 subunit |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YBL035C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
11 structures for P38121
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3FLO | X-ray | 250 A | A/C/E/G | 246-705 | PDB |
| 8B9A | EM | 350 A | B | 1-705 | PDB |
| 8B9B | EM | 350 A | B | 1-705 | PDB |
| 8B9C | EM | 460 A | B | 1-705 | PDB |
| 8FOC | EM | 370 A | C | 1-705 | PDB |
| 8FOD | EM | 380 A | C | 1-705 | PDB |
| 8FOE | EM | 560 A | C | 1-705 | PDB |
| 8FOH | EM | 493 A | C | 1-705 | PDB |
| 8FOJ | EM | 480 A | C | 1-705 | PDB |
| 8FOK | EM | 356 A | C | 1-705 | PDB |
| AF-P38121-F1 | Predicted | AlphaFoldDB |
18 variants for P38121
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-153550 | 22 | T>A | No | SGRP | |
| s02-153423 | 64 | F>C | No | SGRP | |
| s02-153372 | 81 | S>L | No | SGRP | |
| s02-153274 | 114 | L>I | No | SGRP | |
| s02-153231 | 128 | S>F | No | SGRP | |
| s02-153088 | 176 | K>* | No | SGRP | |
| s02-153010 | 202 | E>K | No | SGRP | |
| s02-152952 | 221 | V>A | No | SGRP | |
| s02-152458 | 386 | A>T | No | SGRP | |
| s02-152454 | 387 | N>S | No | SGRP | |
| s02-152369 | 415 | E>D | No | SGRP | |
| s02-152179 | 479 | H>Y | No | SGRP | |
| s02-152076 | 513 | R>K | No | SGRP | |
| s02-151966 | 550 | T>A | No | SGRP | |
| s02-151924 | 564 | I>V | No | SGRP | |
| s02-151868 | 582 | I>M | No | SGRP | |
| s02-151851 | 588 | S>F | No | SGRP | |
| s02-151786 | 610 | A>T | No | SGRP |
No associated diseases with P38121
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| alpha DNA polymerase:primase complex | A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA biosynthetic process | The biosynthetic process resulting in the formation of DNA. |
| DNA replication initiation | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
| lagging strand elongation | The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. |
| telomere capping | A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGSIDVITH | FGPDADKPEI | ITALENLTKL | HALSVEDLYI | KWEQFSNQRR | QTHTDLTSKN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IDEFKQFLQL | QMEKRANQIS | SSSKVNTSTK | KPVIKKSLNS | SPLFGLSIPK | TPTLKKRKLH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GPFSLSDSKQ | TYNVGSEAET | NEKGNSSLKL | EFTPGMAEDA | VGDSAPLSHA | KSSDAKTPGS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| STFQTPTTNT | PTTSRQNVPA | GEILDSLNPE | NIEISSGNPN | VGLLSTEEPS | YNQVKVEPFY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DAKKYKFRTM | RQNLQEASDV | LDDQIESFTK | IIQNHYKLSP | NDFADPTIQS | QSEIYAVGRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VPDSPTYDKF | LNPESLSLET | SRMGGVGRRV | RLDLSQVNEL | SFFLGQIVAF | KGKNANGDYF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVNSILPLPY | PNSPVSTSQE | LQEFQANLEG | SSLKVIVTCG | PYFANDNFSL | ELLQEFIDSI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NNEVKPHVLI | MFGPFIDITH | PLIASGKLPN | FPQFKTQPKT | LDELFLKLFT | PILKTISPHI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QTVLIPSTKD | AISNHAAYPQ | ASLIRKALQL | PKRNFKCMAN | PSSFQINEIY | FGCSNVDTFK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DLKEVIKGGT | TSSRYRLDRV | SEHILQQRRY | YPIFPGSIRT | RIKPKDVSTK | KETNDMESKE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EKVYEHISGA | DLDVSYLGLT | EFVGGFSPDI | MIIPSELQHF | ARVVQNVVVI | NPGRFIRATG |
| 670 | 680 | 690 | 700 | ||
| NRGSYAQITV | QCPDLEDGKL | TLVEGEEPVY | LHNVWKRARV | DLIAS |