AiPD: Autoinhibited Protein Database

Gene name	Pola2
Protein name	DNA polymerase alpha subunit B
Names	DNA polymerase alpha 70 kDa subunit
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:18969
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

48-225 (Predicted disordered autoinhibitory region) PR

48-225 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P33611-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389520980	12	L>P	No	EVA
rs3389521002	23	L>M	No	EVA
rs3389429085	69	V>I	No	EVA
rs36911197	90	T>A	No	EVA
rs3389514685	93	I>N	No	EVA
rs3389519982	135	R>G	No	EVA
rs3389512888	168	G>E	No	EVA
rs37481512	180	L>V	No	EVA
rs39525324	184	G>R	No	EVA
rs3389525309	187	G>D	No	EVA
rs215603600	196	V>M	No	EVA
rs3389529062	253	L>F	No	EVA
rs219041009	271	I>V	No	EVA
rs3389525345	281	G>R	No	EVA
rs3389525287	315	T>S	No	EVA
rs36292020	317	T>I	No	EVA
rs3389518912	350	T>N	No	EVA
rs3389429071	362	D>A	No	EVA
rs3389521036	408	T>I	No	EVA
rs3389518840	409	V>L	No	EVA
rs3389535393	424	P>L	No	EVA
rs3389468285	435	Y>*	No	EVA
rs3389499880	456	V>L	No	EVA
rs3413090673	464	I>K	No	EVA
rs3407824842	474	T>M	No	EVA
rs3389525296	477	L>V	No	EVA
rs3389525352	483	E>D	No	EVA
rs3389514634	501	H>Q	No	EVA
rs3389512013	532	P>S	No	EVA
rs3389519912	584	D>E	No	EVA

Type	Name	Position	InterPro Accession
domain	DNA polymerase alpha/delta/epsilon, subunit B	342 - 549	IPR007185
domain	DNA polymerase alpha, subunit B, N-terminal	22 - 239	IPR013627

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
alpha DNA polymerase:primase complex	A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity	Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

Name	Definition
DNA replication	The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
DNA replication initiation	The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
DNA replication, synthesis of RNA primer	The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis.
protein import into nucleus	The directed movement of a protein from the cytoplasm to the nucleus.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38121	POL12	DNA polymerase alpha subunit B	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q14181	POLA2	DNA polymerase alpha subunit B	Homo sapiens (Human)	PR
O89043	Pola2	DNA polymerase alpha subunit B	Rattus norvegicus (Rat)	PR