P38090
Gene name |
AGP2 (YBR132C, YBR1007) |
Protein name |
General amino acid permease AGP2 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YBR132C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38090
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38090-F1 | Predicted | AlphaFoldDB |
11 variants for P38090
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-501418 | 7 | T>A | No | SGRP | |
| s02-501280 | 53 | P>S | No | SGRP | |
| s02-501195 | 81 | F>S | No | SGRP | |
| s02-500998 | 147 | F>L | No | SGRP | |
| s02-500938 | 167 | V>L | No | SGRP | |
| s02-500830 | 203 | I>V | No | SGRP | |
| s02-500671 | 256 | H>Y | No | SGRP | |
| s02-500314 | 375 | N>H | No | SGRP | |
| s02-499797 | 547 | G>D | No | SGRP | |
| s02-499774 | 555 | I>V | No | SGRP | |
| s02-499698 | 580 | N>I | No | SGRP |
No associated diseases with P38090
1 regional properties for P38090
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphoribosyltransferase domain | 60 - 182 | IPR000836 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| amino acid transmembrane transporter activity | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| amino acid transmembrane transport | The process in which an amino acid is transported across a membrane. |
| positive regulation of (R)-carnitine transmembrane transport | Any process that activates or increases the frequency, rate or extent of (R)-carnitine transmembrane transport. |
| positive regulation of polyamine transmembrane transport | Any process that activates or increases the frequency, rate or extent of polyamine transmembrane transport. |
2 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTKERMTIDY | ENDGDFEYDK | NKYKTITTRI | KSIEPSEGWL | EPSGSVGHIN | TIPEAGDVHV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DEHEDRGSSI | DDDSRTYLLY | FTETRRKLEN | RHVQLIAISG | VIGTALFVAI | GKALYRGGPA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLLLAFALWC | VPILCITVST | AEMVCFFPVS | SPFLRLATKC | VDDSLAVMAS | WNFWFLECVQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IPFEIVSVNT | IIHYWRDDYS | AGIPLAVQVV | LYLLISICAV | KYYGEMEFWL | ASFKIILALG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LFTFTFITML | GGNPEHDRYG | FRNYGESPFK | KYFPDGNDVG | KSSGYFQGFL | ACLIQASFTI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AGGEYISMLA | GEVKRPRKVL | PKAFKQVFVR | LTFLFLGSCL | CVGIVCSPND | PDLTAAINEA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RPGAGSSPYV | IAMNNLKIRI | LPDIVNIALI | TAAFSAGNAY | TYCSSRTFYG | MALDGYAPKI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FTRCNRHGVP | IYSVAISLVW | ALVSLLQLNS | NSAVVLNWLI | NLITASQLIN | FVVLCIVYLF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FRRAYHVQQD | SLPKLPFRSW | GQPYTAIIGL | VSCSAMILIQ | GYTVFFPKLW | NTQDFLFSYL |
| 550 | 560 | 570 | 580 | 590 | |
| MVFINIGIYV | GYKFIWKRGK | DHFKNPHEID | FSKELTEIEN | HEIESSFEKF | QYYSKA |