AiPD: Autoinhibited Protein Database

Gene name	LYP1 (YNL268W, N0790)
Protein name	Lysine-specific permease
Names
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YNL268W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-133 (Predicted disordered autoinhibitory region) PR

1-133 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P32487-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s14-138657	36	E>G	No	SGRP
s14-138666	39	A>V	No	SGRP
s14-138678	43	S>N	No	SGRP
s14-138690	47	T>I	No	SGRP
s14-138699	50	S>F	No	SGRP
s14-138713	55	Q>K	No	SGRP
s14-138752	68	G>S	No	SGRP
s14-138758	70	I>F	No	SGRP
s14-138798	83	L>S	No	SGRP
s14-138801	84	Q>R	No	SGRP
s14-138803	85	V>I	No	SGRP
s14-138818	90	T>P	No	SGRP
s14-138822	91	D>G	No	SGRP
s14-138827	93	N>D	No	SGRP
s14-139010	154	I>V	No	SGRP
s14-139333	261	M>I	No	SGRP
s14-139452	301	S>N	No	SGRP
s14-139631	361	I>V	No	SGRP
s14-139775	409	V>I	No	SGRP
s14-139833	428	R>K	No	SGRP
s14-139836	429	T>S	No	SGRP
s14-139898	450	V>I	No	SGRP
s14-140041	497	M>I	No	SGRP
s14-140231	561	V>M	No	SGRP
s14-140322	591	A>E	No	SGRP

Type	Name	Position	InterPro Accession
conserved_site	Amino acid permease, conserved site	139 - 170	IPR004840
domain	Amino acid permease/ SLC12A domain	114 - 577	IPR004841

		Description
EC Number
Subcellular Localization	Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
eisosome	A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
amino acid transmembrane transporter activity	Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
basic amino acid transmembrane transporter activity	Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3.

Name	Definition
amino acid transmembrane transport	The process in which an amino acid is transported across a membrane.
basic amino acid transport	The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38090	AGP2	General amino acid permease AGP2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P19145	GAP1	General amino-acid permease GAP1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR