P37774

PR
Gene name
tcyN
Protein name
L-cystine transport system ATP-binding protein TcyN
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1917
EC number
7.4.2.12: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

87-174 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P37774

Entry ID Method Resolution Chain Position Source
AF-P37774-F1 Predicted AlphaFoldDB

No variants for P37774

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P37774

No associated diseases with P37774

3 regional properties for P37774

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 4 - 244 IPR003439
domain AAA+ ATPase domain 28 - 221 IPR003593
conserved_site ABC transporter-like, conserved site 145 - 159 IPR017871

Functions

Description
EC Number 7.4.2.12 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ABC-type amino acid transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
L-cystine transmembrane transporter activity Enables the transfer of L-cystine from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
cysteine transmembrane transport The directed movement of cysteine across a membrane.
L-cystine transport The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P07109 hisP Histidine transport ATP-binding protein HisP Escherichia coli (strain K12) PR
P30750 metN Methionine import ATP-binding protein MetN Escherichia coli (strain K12) PR
P10346 glnQ Glutamine transport ATP-binding protein GlnQ Escherichia coli (strain K12) PR
10 20 30 40 50 60
MSAIEVKNLV KKFHGQTVLH GIDLEVKPGE VVAIIGPSGS GKTTLLRSIN LLEQPEAGTI
70 80 90 100 110 120
TVGDITIDTA RSLSQQKSLI RQLRQHVGFV FQNFNLFPHR TVLENIIEGP VIVKGEPKEE
130 140 150 160 170 180
ATARARELLA KVGLAGKETS YPRRLSGGQQ QRVAIARALA MRPEVILFDE PTSALDPELV
190 200 210 220 230 240
GEVLNTIRQL AQEKRTMVIV THEMSFARDV ADRAIFMDQG RIVEQGAAKA LFADPEQPRT
RQFLEKFLLQ