P36195

PR
Gene name
DNTT (TDT)
Protein name
DNA nucleotidylexotransferase
Names
Terminal addition enzyme, Terminal deoxynucleotidyltransferase, Terminal transferase
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396351
EC number
2.7.7.31: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

91-171 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P36195

Entry ID Method Resolution Chain Position Source
AF-P36195-F1 Predicted AlphaFoldDB

3 variants for P36195

Variant ID(s) Position Change Description Diseaes Association Provenance
rs314552024 219 D>E No Ensembl
rs735757795 237 A>V No Ensembl
rs16552430 477 R>S No Ensembl

No associated diseases with P36195

14 regional properties for P36195

Type Name Position InterPro Accession
domain C2 domain 1071 - 1194 IPR000008
domain Phosphatidylinositol-specific phospholipase C, X domain 320 - 465 IPR000909
domain SH2 domain 548 - 657 IPR000980-1
domain SH2 domain 666 - 756 IPR000980-2
domain SH3 domain 791 - 851 IPR001452
domain Phospholipase C, phosphatidylinositol-specific, Y domain 953 - 1070 IPR001711
domain Pleckstrin homology domain 27 - 144 IPR001849-1
domain Pleckstrin homology domain 489 - 680 IPR001849-2
domain Pleckstrin homology domain 804 - 933 IPR001849-3
domain EF-hand domain 152 - 187 IPR002048
binding_site EF-Hand 1, calcium-binding site 165 - 177 IPR018247
domain PLC-gamma, C-terminal SH2 domain 663 - 765 IPR035023
domain PLC-gamma, N-terminal SH2 domain 545 - 649 IPR035024
domain 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain 791 - 850 IPR035724

Functions

Description
EC Number 2.7.7.31 Nucleotidyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA nucleotidylexotransferase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
DNA modification The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P25615 POL4 DNA polymerase IV Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P06526 DNTT DNA nucleotidylexotransferase Bos taurus (Bovine) PR
10 20 30 40 50 60
MERIRPPTVV SQRKRQKGMY SPKLSCGYEI KFNKLVIFIM QRKMGMTRRT FLMELARSKG
70 80 90 100 110 120
FRVESELSDS VTHIVAENNS YPEVLDWLKG QAVGDSSRFE ILDISWLTAC MEMGRPVDLE
130 140 150 160 170 180
KKYHLVEQAG QYPTLKTPES EVSSFTASKV SQYSCQRKTT LNNCNKKFTD AFEIMAENYE
190 200 210 220 230 240
FKENEIFCLE FLRAASVLKS LPFPVTRMKD IQGLPCMGDR VRDVIEEIIE EGESSRAKDV
250 260 270 280 290 300
LNDERYKSFK EFTSVFGVGV KTSEKWFRMG LRTVEEVKAD KTLKLSKMQR AGFLYYEDLV
310 320 330 340 350 360
SCVSKAEADA VSSIVKNTVC TFLPDALVTI TGGFRRGKKI GHDIDFLITS PGQREDDELL
370 380 390 400 410 420
HKGLLLYCDI IESTFVKEQI PSRHVDAMDH FQKCFAILKL YQPRVDNSSY NMSKKCDMAE
430 440 450 460 470 480
VKDWKAIRVD LVITPFEQYA YALLGWTGSR QFGRDLRRYA THERKMMLDN HALYDKRKRV
490 500
FLKAGSEEEI FAHLGLDYVE PWERNA