AiPD: Autoinhibited Protein Database

Gene name	DNTT (TDT)
Protein name	DNA nucleotidylexotransferase
Names	Terminal addition enzyme, Terminal deoxynucleotidyltransferase, TDT, Terminal transferase
Species	Bos taurus (Bovine)
KEGG Pathway	bta:281120
EC number	2.7.7.31: Nucleotidyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-52 (Predicted disordered autoinhibitory region) PR

1-52 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P06526-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs446610835	3	P>Q	No	EVA
rs478044320	3	P>T	No	EVA
rs467029788	5	C>G	No	EVA
rs467029788	5	C>S	No	EVA
rs480735466	6	T>P	No	EVA
rs469358855	19	V>G	No	EVA
rs468755473	21	A>S	No	EVA
rs451975219	31	K>M	No	EVA
rs465625653	33	Q>H	No	EVA
rs472883190	44	M>R	No	EVA
rs441647395	45	G>V	No	EVA
rs455310588	47	T>A	No	EVA
rs475434006	49	R>S	No	EVA
rs444039705	51	F>L	No	EVA
rs457996948	53	M>T	No	EVA
rs478164613	54	E>D	No	EVA
rs440158982	55	L>R	No	EVA
rs460312184	56	A>T	No	EVA
rs480446780	59	K>*	No	EVA
rs449390772	62	R>M	No	EVA
rs469518650	62	R>S	No	EVA
rs483018875	68	S>I	No	EVA
rs470999409	106	W>S	No	EVA
rs439866908	122	K>I	No	EVA
rs433109516	166	H>P	No	EVA
rs433109516	166	H>R	No	EVA
rs1115401960	208	M>V	No	EVA
rs449314549	241	L>*	No	EVA
rs472119394	253	T>S	No	EVA
rs1116878977	313	V>M	No	EVA
rs461518610	372	G>R	No	EVA
rs448952518	376	Y>*	No	EVA
rs481680703	376	Y>D	No	EVA
rs462690992	380	V>G	No	EVA
rs482601998	382	S>P	No	EVA
rs524234164	399	H>N	No	EVA
rs444879498	403	C>F	No	EVA
rs464948901	404	F>L	No	EVA
rs433835474	410	H>Q	No	EVA
rs467544491	411	H>L	No	EVA
rs447501371	411	H>N	No	EVA
rs456464162	412	Q>*	No	EVA
rs136117843	419	S>A	No	EVA
rs432328765	434	L>M	No	EVA
rs432756536	477	Y>D	No	EVA
rs445121454	483	V>E	No	EVA
rs445121454	483	V>G	No	EVA
rs465259804	493	I>S	No	EVA
rs478832692	506	E>K	No	EVA
rs467419336	509	A>S	No	EVA

Type	Name	Position	InterPro Accession
domain	C2 domain	1071 - 1194	IPR000008
domain	Phosphatidylinositol-specific phospholipase C, X domain	320 - 465	IPR000909
domain	SH2 domain	548 - 657	IPR000980-1
domain	SH2 domain	666 - 756	IPR000980-2
domain	SH3 domain	791 - 851	IPR001452
domain	Phospholipase C, phosphatidylinositol-specific, Y domain	953 - 1070	IPR001711
domain	Pleckstrin homology domain	27 - 144	IPR001849-1
domain	Pleckstrin homology domain	489 - 680	IPR001849-2
domain	Pleckstrin homology domain	804 - 933	IPR001849-3
domain	EF-hand domain	152 - 187	IPR002048
binding_site	EF-Hand 1, calcium-binding site	165 - 177	IPR018247
domain	PLC-gamma, C-terminal SH2 domain	663 - 765	IPR035023
domain	PLC-gamma, N-terminal SH2 domain	545 - 649	IPR035024
domain	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain	791 - 850	IPR035724

		Description
EC Number	2.7.7.31	Nucleotidyltransferases
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA nucleotidylexotransferase activity	Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
DNA-directed DNA polymerase activity	Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
metal ion binding	Binding to a metal ion.

Name	Definition
DNA metabolic process	Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
DNA modification	The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.
double-strand break repair via nonhomologous end joining	The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P25615	POL4	DNA polymerase IV	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P36195	DNTT	DNA nucleotidylexotransferase	Gallus gallus (Chicken)	PR