P25615

PR
Gene name
POL4 (POLX, YCR014C, YCR14C)
Protein name
DNA polymerase IV
Names
POL IV
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YCR014C
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

102-206 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P25615

Entry ID Method Resolution Chain Position Source
AF-P25615-F1 Predicted AlphaFoldDB

12 variants for P25615

Variant ID(s) Position Change Description Diseaes Association Provenance
s03-140787 49 V>I No SGRP
s03-140654 93 V>A No SGRP
s03-140476 152 D>E No SGRP
s03-140420 171 G>E No SGRP
s03-140384 183 T>M No SGRP
s03-140336 199 T>K No SGRP
s03-140028 302 K>E No SGRP
s03-139932 334 T>A No SGRP
s03-139838 365 C>S No SGRP
s03-139686 416 K>Q No SGRP
s03-139547 462 M>K No SGRP
s03-139187 582 A>G No SGRP

No associated diseases with P25615

5 regional properties for P25615

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase X 185 - 574 IPR002054
domain DNA polymerase beta-like, N-terminal domain 188 - 254 IPR010996
binding_site DNA polymerase family X, binding site 356 - 375 IPR019843
domain DNA polymerase beta, palm domain 327 - 406 IPR028207
domain DNA polymerase beta, thumb domain 516 - 574 IPR029398

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P06526 DNTT DNA nucleotidylexotransferase Bos taurus (Bovine) PR
P36195 DNTT DNA nucleotidylexotransferase Gallus gallus (Chicken) PR
10 20 30 40 50 60
MSLKGKFFAF LPNPNTSSNK FFKSILEKKG ATIVSSIQNC LQSSRKEVVI LIEDSFVDSD
70 80 90 100 110 120
MHLTQKDIFQ REAGLNDVDE FLGKIEQSGI QCVKTSCITK WVQNDKFAFQ KDDLIKFQPS
130 140 150 160 170 180
IIVISDNADD GQSSTDKESE ISTDVESERN DDSNNKDMIQ ASKPLKRLLQ GDKGRASLVT
190 200 210 220 230 240
DKTKYKNNEL IIGALKRLTK KYEIEGEKFR ARSYRLAKQS MENCDFNVRS GEEAHTKLRN
250 260 270 280 290 300
IGPSIAKKIQ VILDTGVLPG LNDSVGLEDK LKYFKNCYGI GSEIAKRWNL LNFESFCVAA
310 320 330 340 350 360
KKDPEEFVSD WTILFGWSYY DDWLCKMSRN ECFTHLKKVQ KALRGIDPEC QVELQGSYNR
370 380 390 400 410 420
GYSKCGDIDL LFFKPFCNDT TELAKIMETL CIKLYKDGYI HCFLQLTPNL EKLFLKRIVE
430 440 450 460 470 480
RFRTAKIVGY GERKRWYSSE IIKKFFMGVK LSPRELEELK EMKNDEGTLL IEEEEEEETK
490 500 510 520 530 540
LKPIDQYMSL NAKDGNYCRR LDFFCCKWDE LGAGRIHYTG SKEYNRWIRI LAAQKGFKLT
550 560 570 580
QHGLFRNNIL LESFNERRIF ELLNLKYAEP EHRNIEWEKK TA