AiPD: Autoinhibited Protein Database

Gene name	EFT1 (YOR133W, O3317, YOR3317W;, EFT2, YDR385W)
Protein name	Elongation factor 2
Names	EF-2, Eukaryotic elongation factor 2, eEF2, Ribosomal translocase, Translation elongation factor 2
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YOR133W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

24-106 (Predicted disordered autoinhibitory region) PR

24-106 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1N0U	X-ray	212 A	A	1-842	PDB
1N0V	X-ray	285 A	C/D	1-842	PDB
1U2R	X-ray	260 A	A	1-842	PDB
1ZM2	X-ray	307 A	A/C/E	1-842	PDB
1ZM3	X-ray	307 A	A/C/E	1-842	PDB
1ZM4	X-ray	290 A	A/C/E	1-842	PDB
1ZM9	X-ray	280 A	A/C/E	1-842	PDB
2E1R	X-ray	315 A	A	1-842	PDB
2NPF	X-ray	290 A	A/B	1-842	PDB
2P8W	EM	1130 A	T	1-842	PDB
2P8X	EM	970 A	T	1-842	PDB
2P8Y	EM	1170 A	T	1-842	PDB
2P8Z	EM	890 A	T	1-842	PDB
2ZIT	X-ray	300 A	A/C/E	1-842	PDB
3B78	X-ray	250 A	A/C/E	1-842	PDB
3B82	X-ray	235 A	A/C/E	1-842	PDB
3B8H	X-ray	250 A	A/C/E	1-842	PDB
3DNY	EM	1260 A	T	1-842	PDB
4V4B	EM	1170 A	AT	1-842	PDB
5JUO	EM	400 A	DC	1-842	PDB
5JUP	EM	350 A	DC	1-842	PDB
5JUS	EM	420 A	DC	1-842	PDB
5JUT	EM	400 A	DC	1-842	PDB
5JUU	EM	400 A	DC	1-842	PDB
6GQ1	EM	440 A	AZ	3-842	PDB
6GQB	EM	390 A	AZ	3-842	PDB
6GQV	EM	400 A	AX	3-839	PDB
8EUB	EM	252 A	DC	1-842	PDB
8EVQ	EM	272 A	DC	1-842	PDB
8EVR	EM	287 A	DC	1-842	PDB
8EVS	EM	262 A	DC	1-842	PDB
8EWB	EM	287 A	DC	1-842	PDB
AF-P32324-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
s15-575342	82	S>A		No	SGRP
s15-576969	624	G>D		No	SGRP

Type	Name	Position	InterPro Accession
domain	Elongation factor EFG, domain V-like	723 - 812	IPR000640
domain	Translational (tr)-type GTP-binding domain	17 - 346	IPR000795
domain	Translation elongation factor EFTu-like, domain 2	395 - 470	IPR004161
domain	Small GTP-binding protein domain	20 - 164	IPR005225
domain	Translation elongation factor EFG/EF2, domain IV	604 - 721	IPR005517
conserved_site	Tr-type G domain, conserved site	58 - 73	IPR031157
domain	Elongation Factor G, domain II	487 - 548	IPR041095

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

Name	Definition
chaperone binding	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
identical protein binding	Binding to an identical protein or proteins.
ribosome binding	Binding to a ribosome.
rRNA binding	Binding to a ribosomal RNA.
translation elongation factor activity	Functions in chain elongation during polypeptide synthesis at the ribosome.

Name	Definition
maintenance of translational fidelity	Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template.
positive regulation of translational elongation	Any process that activates or increases the frequency, rate or extent of translational elongation.
translational elongation	The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P13639	EEF2	Elongation factor 2	Homo sapiens (Human)	PR
P58252	Eef2	Elongation factor 2	Mus musculus (Mouse)	PR
P05197	Eef2	Elongation factor 2	Rattus norvegicus (Rat)	PR