P32324

PR
Gene name
EFT1 (YOR133W, O3317, YOR3317W;, EFT2, YDR385W)
Protein name
Elongation factor 2
Names
EF-2, Eukaryotic elongation factor 2, eEF2, Ribosomal translocase, Translation elongation factor 2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOR133W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

24-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

33 structures for P32324

Entry ID Method Resolution Chain Position Source
1N0U X-ray 212 A A 1-842 PDB
1N0V X-ray 285 A C/D 1-842 PDB
1U2R X-ray 260 A A 1-842 PDB
1ZM2 X-ray 307 A A/C/E 1-842 PDB
1ZM3 X-ray 307 A A/C/E 1-842 PDB
1ZM4 X-ray 290 A A/C/E 1-842 PDB
1ZM9 X-ray 280 A A/C/E 1-842 PDB
2E1R X-ray 315 A A 1-842 PDB
2NPF X-ray 290 A A/B 1-842 PDB
2P8W EM 1130 A T 1-842 PDB
2P8X EM 970 A T 1-842 PDB
2P8Y EM 1170 A T 1-842 PDB
2P8Z EM 890 A T 1-842 PDB
2ZIT X-ray 300 A A/C/E 1-842 PDB
3B78 X-ray 250 A A/C/E 1-842 PDB
3B82 X-ray 235 A A/C/E 1-842 PDB
3B8H X-ray 250 A A/C/E 1-842 PDB
3DNY EM 1260 A T 1-842 PDB
4V4B EM 1170 A AT 1-842 PDB
5JUO EM 400 A DC 1-842 PDB
5JUP EM 350 A DC 1-842 PDB
5JUS EM 420 A DC 1-842 PDB
5JUT EM 400 A DC 1-842 PDB
5JUU EM 400 A DC 1-842 PDB
6GQ1 EM 440 A AZ 3-842 PDB
6GQB EM 390 A AZ 3-842 PDB
6GQV EM 400 A AX 3-839 PDB
8EUB EM 252 A DC 1-842 PDB
8EVQ EM 272 A DC 1-842 PDB
8EVR EM 287 A DC 1-842 PDB
8EVS EM 262 A DC 1-842 PDB
8EWB EM 287 A DC 1-842 PDB
AF-P32324-F1 Predicted AlphaFoldDB

2 variants for P32324

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-575342 82 S>A No SGRP
s15-576969 624 G>D No SGRP

1 associated diseases with P32324

[MIM: 617561]: Cohen-Gibson syndrome (COGIS)

An autosomal dominant overgrowth disorder characterized by accelerated osseous maturation, advanced bone age, skeletal abnormalities including flaring of the metaphyses of the long bones, large hands with long fingers and camptodactyly, scoliosis, cervical spine anomalies, dysmorphic facial features, and variable intellectual disability. {ECO:0000269|PubMed:25787343, ECO:0000269|PubMed:27193220, ECO:0000269|PubMed:27868325, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:28475857}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID
  • An autosomal dominant overgrowth disorder characterized by accelerated osseous maturation, advanced bone age, skeletal abnormalities including flaring of the metaphyses of the long bones, large hands with long fingers and camptodactyly, scoliosis, cervical spine anomalies, dysmorphic facial features, and variable intellectual disability. {ECO:0000269|PubMed:25787343, ECO:0000269|PubMed:27193220, ECO:0000269|PubMed:27868325, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:28475857}. Note=The disease is caused by variants affecting the gene represented in this entry.

5 regional properties for P32324

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 27 - 249 IPR003439
domain AAA+ ATPase domain 55 - 226 IPR003593
domain ABC transporter, teichoic acids export TagH-like 8 - 231 IPR015860
conserved_site ABC transporter-like, conserved site 150 - 164 IPR017871
domain LysM domain 403 - 448 IPR018392

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

7 GO annotations of molecular function

Name Definition
chaperone binding Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
identical protein binding Binding to an identical protein or proteins.
ribosome binding Binding to a ribosome.
rRNA binding Binding to a ribosomal RNA.
translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome.

3 GO annotations of biological process

Name Definition
maintenance of translational fidelity Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template.
positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation.
translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P13639 EEF2 Elongation factor 2 Homo sapiens (Human) PR
P58252 Eef2 Elongation factor 2 Mus musculus (Mouse) PR
P05197 Eef2 Elongation factor 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MVAFTVDQMR SLMDKVTNVR NMSVIAHVDH GKSTLTDSLV QRAGIISAAK AGEARFTDTR
70 80 90 100 110 120
KDEQERGITI KSTAISLYSE MSDEDVKEIK QKTDGNSFLI NLIDSPGHVD FSSEVTAALR
130 140 150 160 170 180
VTDGALVVVD TIEGVCVQTE TVLRQALGER IKPVVVINKV DRALLELQVS KEDLYQTFAR
190 200 210 220 230 240
TVESVNVIVS TYADEVLGDV QVYPARGTVA FGSGLHGWAF TIRQFATRYA KKFGVDKAKM
250 260 270 280 290 300
MDRLWGDSFF NPKTKKWTNK DTDAEGKPLE RAFNMFILDP IFRLFTAIMN FKKDEIPVLL
310 320 330 340 350 360
EKLEIVLKGD EKDLEGKALL KVVMRKFLPA ADALLEMIVL HLPSPVTAQA YRAEQLYEGP
370 380 390 400 410 420
ADDANCIAIK NCDPKADLML YVSKMVPTSD KGRFYAFGRV FAGTVKSGQK VRIQGPNYVP
430 440 450 460 470 480
GKKDDLFIKA IQRVVLMMGR FVEPIDDCPA GNIIGLVGID QFLLKTGTLT TSETAHNMKV
490 500 510 520 530 540
MKFSVSPVVQ VAVEVKNAND LPKLVEGLKR LSKSDPCVLT YMSESGEHIV AGTGELHLEI
550 560 570 580 590 600
CLQDLEHDHA GVPLKISPPV VAYRETVESE SSQTALSKSP NKHNRIYLKA EPIDEEVSLA
610 620 630 640 650 660
IENGIINPRD DFKARARIMA DDYGWDVTDA RKIWCFGPDG NGPNLVIDQT KAVQYLHEIK
670 680 690 700 710 720
DSVVAAFQWA TKEGPIFGEE MRSVRVNILD VTLHADAIHR GGGQIIPTMR RATYAGFLLA
730 740 750 760 770 780
DPKIQEPVFL VEIQCPEQAV GGIYSVLNKK RGQVVSEEQR PGTPLFTVKA YLPVNESFGF
790 800 810 820 830 840
TGELRQATGG QAFPQMVFDH WSTLGSDPLD PTSKAGEIVL AARKRHGMKE EVPGWQEYYD
KL