P25103
PR
Gene name |
TACR1 (NK1R, TAC1R) |
Protein name |
Substance-P receptor |
Names |
SPR, NK-1 receptor, NK-1R, Tachykinin receptor 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:6869 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
14 structures for P25103
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2KS9 | NMR | - | A | 1-364 | PDB |
| 2KSA | NMR | - | A | 1-364 | PDB |
| 2KSB | NMR | - | A | 1-364 | PDB |
| 6E59 | X-ray | 340 A | PDB | ||
| 6HLL | X-ray | 327 A | PDB | ||
| 6HLO | X-ray | 240 A | PDB | ||
| 6HLP | X-ray | 220 A | PDB | ||
| 7P00 | EM | 271 A | R | 1-335 | PDB |
| 7P02 | EM | 287 A | R | 1-335 | PDB |
| 7RMG | EM | 300 A | R | 1-407 | PDB |
| 7RMH | EM | 310 A | R | 1-407 | PDB |
| 7RMI | EM | 320 A | R | 1-407 | PDB |
| 8U26 | EM | 250 A | R | 1-407 | PDB |
| AF-P25103-F1 | Predicted | AlphaFoldDB |
342 variants for P25103
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA50556531 rs1003492126 |
2 | D>N | No |
ClinGen Ensembl |
|
|
rs1341473373 CA347436286 |
3 | N>D | No |
ClinGen gnomAD |
|
|
rs200221211 CA1732282 |
3 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732281 rs752537876 |
5 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765041152 CA347436266 |
6 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA1732280 rs765041152 |
6 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs145997324 CA1732279 |
7 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA50556522 rs199617380 |
8 | D>E | No |
ClinGen TOPMed |
|
|
rs1407474432 CA347436245 |
10 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
CA50556515 rs201426785 |
12 | S>Y | No |
ClinGen Ensembl |
|
|
rs776049144 CA1732277 |
13 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732275 rs765949130 |
14 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347436221 rs765949130 |
14 | N>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1187713805 CA347436201 |
17 | T>A | No |
ClinGen gnomAD |
|
|
CA1732274 rs79405056 |
20 | S>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA50556504 rs79405056 |
20 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA50556489 rs897077411 |
23 | N>S | No |
ClinGen gnomAD |
|
|
rs748575268 CA1732271 |
24 | Q>K | No |
ClinGen ExAC |
|
|
CA347436126 rs1314449865 |
28 | P>S | No |
ClinGen Ensembl |
|
|
rs1395207852 CA347436119 |
29 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
CA347436121 rs1323400882 |
29 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
CA347436122 rs1323400882 |
29 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1041501890 CA50556464 |
30 | W>L | No |
ClinGen TOPMed gnomAD |
|
|
rs200409378 COSM196257 CA50556461 |
31 | Q>K | large_intestine [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA1732270 rs774680314 |
32 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1289844570 CA347436091 |
33 | V>A | No |
ClinGen gnomAD |
|
|
rs1332338004 CA347436094 |
33 | V>F | No |
ClinGen gnomAD |
|
| TCGA novel | 34 | L>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs202111284 CA50556453 |
34 | L>I | No |
ClinGen Ensembl |
|
|
CA1732269 rs768808935 |
35 | W>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732268 rs749494089 |
37 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769294302 CA50556429 |
38 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs780098587 CA1732267 |
40 | T>R | No |
ClinGen ExAC gnomAD |
|
|
CA1732266 rs756238660 |
41 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347436047 rs756238660 |
41 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732265 rs745879026 |
42 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732264 rs777925661 |
43 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA347436031 rs267599465 |
44 | V>L | No |
ClinGen TOPMed |
|
|
rs267599465 CA50556420 |
44 | V>M | No |
ClinGen TOPMed |
|
|
CA1732263 rs758398511 |
45 | T>N | No |
ClinGen ExAC gnomAD |
|
|
CA1732261 rs765098258 |
47 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs765098258 CA1732262 |
47 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA1732260 rs754693735 |
48 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA1732259 rs142157446 |
49 | G>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA1732258 rs142157446 |
49 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs147650877 CA1732257 |
51 | V>M | No |
ClinGen ESP ExAC TOPMed |
|
|
rs768067224 CA1732255 |
52 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA347435964 rs1176919257 |
55 | W>* | No |
ClinGen TOPMed |
|
| TCGA novel | 55 | W>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 56 | I>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA50556381 rs914457277 |
58 | L>S | No |
ClinGen TOPMed |
|
|
rs769096225 CA347435937 |
59 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732252 rs769096225 |
59 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201437956 CA1732250 |
65 | T>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA347435891 rs769905459 |
65 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA1732249 rs769905459 |
65 | T>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 66 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1732248 rs759108653 |
73 | N>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200411690 CA1732247 |
74 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs202095119 CA347435831 |
75 | A>P | No |
ClinGen gnomAD |
|
|
CA50556352 rs202095119 |
75 | A>S | No |
ClinGen gnomAD |
|
|
rs1321606135 CA347435819 |
77 | A>T | No |
ClinGen gnomAD |
|
|
rs1362305026 CA347435803 |
79 | A>T | No |
ClinGen gnomAD |
|
|
rs200986020 CA1732244 |
80 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732242 rs754819440 |
81 | M>K | No |
ClinGen ExAC gnomAD |
|
|
CA1732243 rs754819440 |
81 | M>R | No |
ClinGen ExAC gnomAD |
|
|
CA50556317 rs78575827 |
82 | A>T | No |
ClinGen Ensembl |
|
|
CA347435780 rs1461673972 |
83 | A>S | No |
ClinGen TOPMed |
|
|
CA347435779 rs1452463250 |
83 | A>V | No |
ClinGen gnomAD |
|
|
rs201404494 CA1732240 |
85 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA1732239 rs755746629 |
86 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA50556285 rs200083063 |
86 | T>I | No |
ClinGen gnomAD |
|
|
rs1558591285 CA347435755 |
87 | V>A | No |
ClinGen Ensembl |
|
|
rs888248509 CA50556248 |
87 | V>M | No |
ClinGen Ensembl |
|
|
CA1732238 rs749939739 |
88 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs1232793733 CA347435741 |
89 | N>K | No |
ClinGen gnomAD |
|
|
CA347435731 rs1572997809 |
91 | T>P | No |
ClinGen Ensembl |
|
|
CA50556233 rs111831416 |
92 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
CA347435725 rs1368013417 |
92 | Y>D | No |
ClinGen gnomAD |
|
|
CA347435721 rs111831416 |
92 | Y>F | No |
ClinGen TOPMed gnomAD |
|
|
rs140963123 CA50556226 |
93 | A>V | No |
ClinGen ESP TOPMed |
|
|
CA347435703 rs1304883917 |
95 | H>R | No |
ClinGen gnomAD |
|
|
CA347435696 rs1572997782 |
96 | N>S | No |
ClinGen Ensembl |
|
|
rs373848086 CA1732236 |
97 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA892986717 rs1293328591 |
99 | Y>* | No |
ClinGen TOPMed |
|
|
CA1732235 rs202089843 COSM1023121 |
99 | Y>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs764449198 CA347435662 |
100 | Y>* | No |
ClinGen ExAC TOPMed |
|
|
rs763443404 CA1732233 |
101 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs151061456 CA1732232 |
102 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 103 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1732229 rs759800948 |
104 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
rs1202200719 CA347435630 |
105 | C>* | No |
ClinGen TOPMed |
|
|
CA347435634 rs1481803235 |
105 | C>G | No |
ClinGen TOPMed |
|
|
CA1732228 rs776956813 |
107 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs139625218 CA347435598 |
109 | N>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA347435601 rs1485777217 |
109 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
CA1732226 rs747030959 |
110 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs6715729 CA347435584 |
111 | F>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1252414158 CA347435577 |
112 | P>H | No |
ClinGen gnomAD |
|
|
rs200803720 CA1732224 |
113 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA347435575 rs1227340812 |
113 | I>V | No |
ClinGen gnomAD |
|
|
CA1732223 COSM1023120 rs749162463 |
114 | A>T | Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA1732220 rs750106834 |
115 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1356527081 CA347435557 |
116 | V>A | No |
ClinGen TOPMed |
|
|
CA1732219 rs780773392 |
116 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA50556144 rs199510054 |
118 | A>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs199510054 CA1732218 |
118 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 118 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347435544 rs1168480920 |
118 | A>V | No |
ClinGen gnomAD |
|
|
CA1732217 rs750965713 |
120 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 122 | S>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA50556132 rs867276009 |
122 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA347435515 rs1166692591 |
123 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
CA1732216 rs138993766 |
124 | T>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA1732215 rs138993766 |
124 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA347435503 rs1455015693 |
125 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA347435490 rs753146275 |
127 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA1732214 rs753146275 |
127 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA347435472 rs1483790281 |
129 | D>E | No |
ClinGen gnomAD |
|
|
rs77755890 CA50556108 |
129 | D>Y | No |
ClinGen Ensembl |
|
|
rs1332840486 CA347434650 |
131 | Y>* | No |
ClinGen gnomAD |
|
|
CA347434642 rs1251737582 |
132 | M>I | No |
ClinGen TOPMed |
|
|
CA1732187 rs761903018 |
135 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1572941730 CA347434585 |
138 | L>P | No |
ClinGen Ensembl |
|
|
rs775302960 CA1732186 |
139 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA1732183 rs776389041 |
141 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA50504668 rs756232781 |
141 | R>W | No |
ClinGen Ensembl |
|
|
CA347434551 rs1157559025 |
142 | L>V | No |
ClinGen gnomAD |
|
|
rs770612891 CA1732182 |
144 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA50504659 rs375620736 |
144 | A>S | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs375620736 CA347434526 |
144 | A>T | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs746672619 CA1732181 |
149 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs1057106168 CA50504652 |
150 | V>A | No |
ClinGen Ensembl |
|
|
rs1558559971 CA347434436 |
151 | I>L | No |
ClinGen Ensembl |
|
|
rs777435415 CA1732180 |
152 | C>S | No |
ClinGen ExAC gnomAD |
|
|
rs757863219 CA1732179 |
152 | C>W | No |
ClinGen ExAC gnomAD |
|
|
CA347434419 rs777435415 |
152 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs779632430 CA1732177 |
153 | V>D | No |
ClinGen ExAC gnomAD |
|
|
CA1732178 rs201913449 |
153 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs1449279785 CA347434375 |
156 | V>F | No |
ClinGen gnomAD |
|
|
rs372730735 CA50504635 |
158 | A>V | No |
ClinGen ESP |
|
|
rs1203612862 CA347434315 |
161 | L>M | No |
ClinGen gnomAD |
|
|
rs138737257 CA50504618 |
162 | A>V | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs1477329809 CA347434269 |
164 | P>L | No |
ClinGen TOPMed |
|
|
rs1234984839 CA347434252 |
166 | G>S | No |
ClinGen gnomAD |
|
|
rs1170694030 CA347434218 |
168 | Y>C | No |
ClinGen TOPMed |
|
|
CA347434207 rs1375156597 |
169 | S>A | No |
ClinGen TOPMed |
|
|
rs1301081718 CA347434199 |
170 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs754300079 CA1732175 |
171 | T>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 174 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1732171 rs767720428 |
174 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732172 rs750632743 |
174 | M>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA50504588 rs199793484 |
175 | P>R | No |
ClinGen 1000Genomes |
|
|
rs1173750677 CA347434096 |
177 | R>K | No |
ClinGen gnomAD |
|
|
CA1732169 rs199687081 |
179 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs150873497 CA1732170 COSM1641987 |
179 | V>M | stomach [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC gnomAD |
|
CA347434063 rs1296466317 |
180 | C>R | No |
ClinGen TOPMed |
|
|
rs765209335 CA1732168 |
181 | M>K | No |
ClinGen ExAC gnomAD |
|
|
CA347434009 rs561350321 |
182 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
CA1732167 rs759439782 |
183 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1191366654 CA347433988 |
184 | W>R | No |
ClinGen gnomAD |
|
| TCGA novel | 185 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs200026957 CA1732166 |
186 | E>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs114919074 CA1732164 |
188 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA1732162 rs771754437 |
190 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA1732159 rs201688433 |
192 | Y>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1732160 rs778539969 |
192 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
CA1732161 VAR_026826 rs200685841 |
192 | Y>H | display properties similar to those of the wild-type receptor [UniProt] | No |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
rs1356998578 CA347433840 |
194 | K>N | No |
ClinGen gnomAD |
|
|
CA50442791 rs200650399 |
196 | Y>* | No |
ClinGen TOPMed |
|
|
CA50442781 rs78869449 |
201 | T>A | No |
ClinGen gnomAD |
|
| TCGA novel | 201 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs771674417 CA347435405 |
202 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs771674417 CA1732145 |
202 | V>M | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 205 | Y>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1732142 rs746915919 |
212 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347435338 rs1480311822 |
213 | G>S | No |
ClinGen gnomAD |
|
|
rs200262291 CA50442724 |
214 | Y>* | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA347435329 rs1232249282 |
214 | Y>C | No |
ClinGen gnomAD |
|
|
rs199593242 CA50442752 |
214 | Y>H | No |
ClinGen TOPMed |
|
|
CA1732141 rs748748122 |
215 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs199512420 CA1732137 |
218 | V>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs200932811 CA1732138 |
218 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1732139 rs200932811 |
218 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs757523905 CA1732136 |
219 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA1732134 rs201060197 |
221 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA50442632 rs200179878 |
221 | I>T | No |
ClinGen Ensembl |
|
|
rs758481738 CA1732133 |
222 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1460165420 CA347435277 |
224 | W>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1021820513 CA50442616 |
225 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
rs967509938 CA50442617 |
225 | A>T | No |
ClinGen Ensembl |
|
|
rs1021820513 CA347435267 COSM1669095 |
225 | A>V | lung [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
CA50442612 rs779156313 |
226 | S>T | No |
ClinGen Ensembl |
|
|
CA347435254 rs1160030771 |
227 | E>G | No |
ClinGen gnomAD |
|
|
rs201835779 CA50442583 |
230 | G>E | No |
ClinGen Ensembl |
|
|
rs1011770323 CA50442585 |
230 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1455513856 CA347435231 |
231 | D>Y | No |
ClinGen gnomAD |
|
|
rs750222579 CA1732128 |
232 | S>A | No |
ClinGen ExAC gnomAD |
|
|
CA1732127 rs767373067 |
232 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
CA1732125 rs774156041 |
235 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347435206 rs774156041 |
235 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201281474 CA1732124 |
235 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA347435207 rs774156041 |
235 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762618882 CA1732123 |
236 | Y>S | No |
ClinGen ExAC gnomAD |
|
|
CA1732121 rs200225041 CA1732120 |
237 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776956215 CA1732119 |
238 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732117 rs148906237 |
240 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs148906237 CA347435173 |
240 | V>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771299689 CA1732118 |
240 | V>F | No |
ClinGen ExAC gnomAD |
|
|
CA50442468 rs779651637 |
244 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs779023517 CA1732113 |
244 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732114 rs779023517 |
244 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA50440873 rs1007761974 |
248 | K>I | No |
ClinGen Ensembl |
|
|
rs1467966283 CA347435093 |
250 | M>I | No |
ClinGen gnomAD |
|
|
rs1010786840 CA50440872 |
250 | M>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 251 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1160245395 CA347435088 |
251 | I>T | No |
ClinGen TOPMed |
|
|
rs199946496 CA50440871 |
252 | V>A | No |
ClinGen gnomAD |
|
| TCGA novel | 252 | V>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1732097 rs17838409 |
253 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA1732096 rs17838409 |
253 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA347435076 rs1434484641 |
254 | V>M | No |
ClinGen TOPMed |
|
|
CA347435057 rs1260610193 |
256 | T>I | No |
ClinGen gnomAD |
|
|
CA347435062 rs1573455687 |
256 | T>P | No |
ClinGen Ensembl |
|
|
rs748429716 CA1732094 |
258 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA347435039 rs1199292536 |
259 | I>T | No |
ClinGen gnomAD |
|
|
CA1732093 rs778949548 |
259 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA347435035 rs1176440954 |
260 | C>S | No |
ClinGen TOPMed gnomAD |
|
|
CA1732092 rs146827057 |
266 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732091 rs749256520 |
267 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs1178932778 CA347434970 |
269 | L>F | No |
ClinGen gnomAD |
|
|
CA347434967 rs1573455649 |
269 | L>P | No |
ClinGen Ensembl |
|
|
CA1732089 rs757245314 |
273 | I>L | No |
ClinGen ExAC gnomAD |
|
|
rs201925544 CA50440813 |
274 | N>H | No |
ClinGen Ensembl |
|
|
rs1480830612 CA347434933 |
275 | P>A | No |
ClinGen gnomAD |
|
|
CA347434913 rs1236754173 |
278 | Y>H | No |
ClinGen TOPMed gnomAD |
|
|
CA347434884 rs1354959900 |
282 | F>L | No |
ClinGen gnomAD |
|
|
rs1318186099 CA347434872 |
283 | I>T | No |
ClinGen TOPMed |
|
| TCGA novel | 285 | Q>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs777679973 CA1732087 |
285 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1398553369 CA347434843 |
287 | Y>S | No |
ClinGen TOPMed gnomAD |
|
|
rs892485171 CA50440806 |
288 | L>M | No |
ClinGen Ensembl |
|
|
rs752408117 CA1732085 |
291 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA1732086 rs758218510 |
291 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs1421203675 CA347434815 |
292 | W>R | No |
ClinGen gnomAD |
|
| TCGA novel | 294 | A>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1732083 rs759153892 |
299 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA50440777 rs200700901 |
300 | Y>H | No |
ClinGen Ensembl |
|
| TCGA novel | 303 | I>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1732080 rs565696241 |
303 | I>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA |
|
rs201272146 CA1732078 |
304 | I>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs772444222 CA1732077 |
304 | I>N | No |
ClinGen ExAC gnomAD |
|
|
CA347434718 rs1195715045 |
306 | C>R | No |
ClinGen TOPMed gnomAD |
|
|
CA347434693 rs1349182372 |
309 | N>S | No |
ClinGen TOPMed |
|
|
CA347434686 rs1208142304 |
310 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
CA1732074 rs768753495 |
310 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
CA1732053 CA50439827 rs770008587 |
311 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732052 rs745877085 |
313 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA1732051 rs148591370 |
313 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs771891340 CA1732050 |
314 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA50439786 rs943880556 |
316 | F>L | No |
ClinGen TOPMed |
|
|
CA1732048 rs778544609 |
317 | K>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA50439778 rs144236507 |
318 | H>P | No |
ClinGen ESP |
|
|
CA1732047 rs754766562 |
319 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA347434516 rs754766562 |
319 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA1732044 rs755621824 |
321 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732045 rs371933483 |
321 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs199619032 CA50439771 |
323 | C>* | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 325 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347434431 rs1447820377 |
326 | I>N | No |
ClinGen gnomAD |
|
| TCGA novel | 327 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs78966502 CA1732041 |
328 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs200415478 CA1732039 |
329 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1732037 rs200032946 |
330 | D>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA50439745 rs201129412 |
331 | Y>C | No |
ClinGen gnomAD |
|
|
rs1383935038 CA347434365 |
331 | Y>H | No |
ClinGen TOPMed |
|
|
rs200374832 CA50439716 |
332 | E>K | No |
ClinGen gnomAD |
|
|
CA347434328 rs1424374012 |
334 | L>M | No |
ClinGen TOPMed |
|
|
CA347434324 rs1297138677 |
334 | L>R | No |
ClinGen gnomAD |
|
|
rs1314065780 CA347434268 |
338 | S>F | No |
ClinGen gnomAD |
|
|
rs1304150939 CA347434274 |
338 | S>P | No |
ClinGen TOPMed |
|
|
rs573144142 COSM3380221 CA1732033 |
340 | R>Q | pancreas [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs776833375 CA1732034 |
340 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA50439677 rs368651206 |
342 | L>F | No |
ClinGen ESP |
|
|
CA347434196 rs1191759604 |
344 | T>P | No |
ClinGen gnomAD |
|
|
CA1732030 rs202219935 |
347 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732029 rs749012386 |
348 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA347434149 rs749012386 |
348 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1311284373 CA347434136 |
349 | Y>C | No |
ClinGen TOPMed |
|
|
CA1732028 rs779746590 |
351 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA50439629 rs1034430892 |
351 | V>I | No |
ClinGen TOPMed |
|
|
rs201228266 CA1732027 |
352 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA50439620 rs904268415 |
352 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs374522374 CA1732026 |
353 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs371093415 CA1732025 |
353 | R>H | No |
ClinGen ESP ExAC gnomAD |
|
|
rs374522374 CA347434089 |
353 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1732024 rs199913774 |
354 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1216381612 CA347434065 |
355 | E>D | No |
ClinGen gnomAD |
|
| TCGA novel | 355 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs752029294 CA1732023 |
357 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA1732021 rs545676777 |
361 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs150773283 CA1732017 |
365 | H>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs758900745 CA1732019 |
365 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200902232 CA1732016 |
366 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA50439605 rs200079158 |
367 | E>A | No |
ClinGen Ensembl |
|
|
rs201920133 CA50439602 |
368 | E>D | No |
ClinGen Ensembl |
|
|
CA1732015 rs776875476 |
369 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA347433908 rs776875476 |
369 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760755179 CA347433859 |
372 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs1460839935 CA347433862 |
372 | G>S | No |
ClinGen TOPMed |
|
|
CA1732013 COSM315764 rs760755179 |
372 | G>V | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA347433851 rs1438224982 |
373 | P>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1438224982 CA347433849 |
373 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA1732011 rs768630359 |
376 | T>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768630359 CA347433821 |
376 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749136258 CA1732010 |
377 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA1732009 rs140559234 |
378 | S>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA347433788 rs1376327678 |
381 | D>V | No |
ClinGen gnomAD |
|
|
CA347433775 rs1281842470 |
383 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1281842470 CA347433776 |
383 | T>S | No |
ClinGen TOPMed gnomAD |
|
|
CA1732006 rs780848437 |
384 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA1732007 rs745548764 |
384 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1463284392 CA347433766 |
385 | N>S | No |
ClinGen gnomAD |
|
|
CA50439570 rs200756266 |
387 | S>T | No |
ClinGen gnomAD |
|
|
CA1732003 rs778203444 |
389 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732004 rs778203444 |
389 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA50439552 COSM1690736 rs199512029 |
389 | R>Q | Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA1732001 rs779454541 |
390 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1732000 rs779454541 |
390 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA50439534 rs200318180 |
391 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs200318180 CA1731999 |
391 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA1731998 rs754025280 |
393 | K>E | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 394 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA347433712 rs1176548618 |
394 | T>N | No |
ClinGen gnomAD |
|
|
CA347433707 rs1558535594 |
395 | M>T | No |
ClinGen Ensembl |
|
|
rs1553370620 CA1731996 |
395 | M>V | No |
ClinGen Ensembl |
|
|
rs1469600968 CA347433696 |
396 | T>I | No |
ClinGen gnomAD |
|
|
rs760729846 CA1731994 |
399 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA347433658 rs1319442150 |
401 | F>L | No |
ClinGen gnomAD |
|
|
rs145317978 CA50439522 |
404 | N>S | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs200290815 CA50439516 |
407 | S>P | No |
ClinGen Ensembl |
|
|
CA347433619 rs1192958701 |
408 | S>Q | No |
ClinGen TOPMed |
No associated diseases with P25103
1 regional properties for P25103
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 49 - 305 | IPR017452 |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell body | The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| sperm flagellum | A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. |
| sperm head | The part of the late spermatid or spermatozoon that contains the nucleus and acrosome. |
| sperm midpiece | The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| substance P receptor activity | Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity. |
| tachykinin receptor activity | Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein. |
44 GO annotations of biological process
| Name | Definition |
|---|---|
| acute inflammatory response | Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. |
| aggressive behavior | A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual. |
| angiotensin-mediated drinking behavior | The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst. |
| associative learning | Learning by associating a stimulus (the cause) with a particular outcome (the effect). |
| behavioral response to pain | Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. |
| detection of abiotic stimulus | The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. |
| eating behavior | The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| long-term memory | The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. |
| operant conditioning | Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior. |
| phospholipase C-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| positive regulation of action potential | Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. |
| positive regulation of blood pressure | Any process in which the force of blood traveling through the circulatory system is increased. |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| positive regulation of epithelial cell migration | Any process that activates or increases the frequency, rate or extent of epithelial cell migration. |
| positive regulation of epithelial cell proliferation | Any process that activates or increases the rate or extent of epithelial cell proliferation. |
| positive regulation of flagellated sperm motility | Any process that activates or increases the frequency, rate or extent of flagellated sperm motility. |
| positive regulation of hormone secretion | Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. |
| positive regulation of leukocyte migration | Any process that activates or increases the frequency, rate, or extent of leukocyte migration. |
| positive regulation of lymphocyte proliferation | Any process that activates or increases the rate or extent of lymphocyte proliferation. |
| positive regulation of ossification | Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. |
| positive regulation of renal sodium excretion | Any process that increases the amount of sodium excreted in urine over a unit of time. |
| positive regulation of saliva secretion | Any process that activates or increases the frequency, rate or extent of the regulated release of saliva. |
| positive regulation of stress fiber assembly | Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
| positive regulation of synaptic transmission, cholinergic | Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. |
| positive regulation of synaptic transmission, GABAergic | Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
| positive regulation of uterine smooth muscle contraction | Any process that increases the frequency, rate or extent of uterine smooth muscle contraction. |
| positive regulation of vascular permeability | Any process that increases the extent to which blood vessels can be pervaded by fluid. |
| positive regulation of vasoconstriction | Any process that activates or increases the frequency, rate or extent of vasoconstriction. |
| regulation of smooth muscle cell migration | Any process that modulates the frequency, rate or extent of smooth muscle cell migration. |
| regulation of smooth muscle cell proliferation | Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. |
| response to auditory stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. |
| response to electrical stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. |
| response to estradiol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. |
| response to ethanol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| response to morphine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. |
| response to nicotine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. |
| response to ozone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus. |
| response to progesterone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. |
| sensory perception of pain | The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. |
| smooth muscle contraction involved in micturition | The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body. |
| sperm ejaculation | The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract. |
| tachykinin receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. Tachykinin is a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2). |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5DUB3 | TACR1 | Substance-P receptor | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P29371 | TACR3 | Neuromedin-K receptor | Homo sapiens (Human) | PR |
| P47937 | Tacr3 | Neuromedin-K receptor | Mus musculus (Mouse) | PR |
| P30548 | Tacr1 | Substance-P receptor | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDNVLPVDSD | LSPNISTNTS | EPNQFVQPAW | QIVLWAAAYT | VIVVTSVVGN | VVVMWIILAH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KRMRTVTNYF | LVNLAFAEAS | MAAFNTVVNF | TYAVHNEWYY | GLFYCKFHNF | FPIAAVFASI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YSMTAVAFDR | YMAIIHPLQP | RLSATATKVV | ICVIWVLALL | LAFPQGYYST | TETMPSRVVC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MIEWPEHPNK | IYEKVYHICV | TVLIYFLPLL | VIGYAYTVVG | ITLWASEIPG | DSSDRYHEQV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SAKRKVVKMM | IVVVCTFAIC | WLPFHIFFLL | PYINPDLYLK | KFIQQVYLAI | MWLAMSSTMY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPIIYCCLND | RFRLGFKHAF | RCCPFISAGD | YEGLEMKSTR | YLQTQGSVYK | VSRLETTIST |
| 370 | 380 | 390 | 400 | ||
| VVGAHEEEPE | DGPKATPSSL | DLTSNCSSRS | DSKTMTESFS | FSSNVLS |