Q5DUB3
Gene name |
TACR1 |
Protein name |
Substance-P receptor |
Names |
SPR, NK-1 receptor, NK-1R, Tachykinin receptor 1 |
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:403815 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5DUB3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5DUB3-F1 | Predicted | AlphaFoldDB |
2 variants for Q5DUB3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs852981679 | 330 | D>N | No | EVA | |
| rs22606118 | 386 | G>S | No | EVA |
No associated diseases with Q5DUB3
1 regional properties for Q5DUB3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 49 - 305 | IPR017452 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| sperm head | The part of the late spermatid or spermatozoon that contains the nucleus and acrosome. |
| sperm midpiece | The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| substance P receptor activity | Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| positive regulation of flagellated sperm motility | Any process that activates or increases the frequency, rate or extent of flagellated sperm motility. |
| regulation of uterine smooth muscle contraction | Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction. |
| response to pain | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDNVLQVDSD | LFPNISTNTS | EPNQFVQPAW | QIVLWAAAYT | VIVVTSVVGN | VVVMWIILAH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KRMRTVTNYF | LVNLAFAEAS | MAAFNTVVNF | TYAVHNEWYY | GLFYCKFHNF | FPIAAVFASI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YSMTAVAFDR | YMAIIHPLQP | RLSATATKVV | ICVIWVLALL | LAFPQGYYST | TETMPNRVVC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MIEWPEHPNK | IYEKVYHICV | TVLIYFLPLL | VIGYAYTVVG | ITLWASEIPG | DSSDRYHEQV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SAKRKVVKMM | IVVVCTFAIC | WLPFHIFFLL | PYINPDLYLE | KFIQQVYLAI | MWLAMSSTMY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPIIYCCLND | RFRLGFKHAF | RCCPFISAGD | YEGLEMKSTR | YLQTQGSVYK | VSRLETTVST |
| 370 | 380 | 390 | 400 | ||
| VVGAHEEELE | DGPKTTPSSL | DLTSNGSSRS | DSKTMTESFS | FYSNMLS |