P23780

PR
Gene name
Glb1 (Bgl, Glb-1)
Protein name
Beta-galactosidase
Names
Acid beta-galactosidase, Lactase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:12091
EC number
3.2.1.23: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

503-576 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P23780

Entry ID Method Resolution Chain Position Source
7KDV EM 459 A A/C/E/G/I/K 28-647 PDB
AF-P23780-F1 Predicted AlphaFoldDB

45 variants for P23780

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389067356 28 V>F No EVA
rs3400800301 42 F>E No EVA
rs3389090343 43 L>H No EVA
rs3389081795 107 H>Y No EVA
rs3389090329 117 L>I No EVA
rs3389085680 165 V>I No EVA
rs3389055986 178 G>R No EVA
rs3389090387 190 Y>* No EVA
rs222529600 205 V>A No EVA
rs3389080016 220 T>I No EVA
rs3389074032 228 M>L No EVA
rs37237603 233 T>S No EVA
rs3389076888 248 N>K No EVA
rs3389080217 274 W>S No EVA
rs3389085722 320 G>D No EVA
rs3389046995 350 A>V No EVA
rs3389090361 369 S>T No EVA
rs241630917 391 G>S No EVA
rs3389046973 392 I>N No EVA
rs3389074055 413 Y>* No EVA
rs3389085733 422 T>M No EVA
rs3389083479 431 K>Q No EVA
rs3389080005 437 P>T No EVA
rs3389055997 444 R>L No EVA
rs3400786550 451 G>E No EVA
rs3389056038 458 D>E No EVA
rs223952699 461 L>R No EVA
rs257322007 464 A>T No EVA
rs30472995 468 R>Q No EVA
rs3389082025 482 M>L No EVA
rs231562151 503 I>L No EVA
rs3389090335 509 T>I No EVA
rs3389055972 510 N>K No EVA
rs48674720 517 N>D No EVA
rs3389026426 531 A>S No EVA
rs13461693 534 E>G No EVA
rs38123790 539 G>R No EVA
rs263609732 540 R>Q No EVA
rs3389082033 544 N>I No EVA
rs224645180 554 Y>* No EVA
rs3389046998 562 S>P No EVA
rs3389081340 582 Q>K No EVA
rs226546538 597 M>V No EVA
rs244247862 601 K>M No EVA
rs3389067428 615 P>S No EVA

No associated diseases with P23780

3 regional properties for P23780

Type Name Position InterPro Accession
conserved_site Glycoside hydrolase, family 35, conserved site 178 - 190 IPR019801
domain Beta-galactosidase jelly roll domain 552 - 621 IPR025300
domain Glycoside hydrolase 35, catalytic domain 42 - 357 IPR031330

Functions

Description
EC Number 3.2.1.23 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Lysosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

4 GO annotations of molecular function

Name Definition
beta-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
galactoside binding Binding to a glycoside in which the sugar group is galactose.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
protein homodimerization activity Binding to an identical protein to form a homodimer.

4 GO annotations of biological process

Name Definition
cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.
galactose catabolic process The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.
response to cortisone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues.
response to Thyroglobulin triiodothyronine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O19015 GLB1 Beta-galactosidase Felis catus (Cat) (Felis silvestris catus) PR
Q9TRY9 GLB1 Beta-galactosidase Canis lupus familiaris (Dog) (Canis familiaris) PR
A2RSQ1 Glb1l3 Beta-galactosidase-1-like protein 3 Mus musculus (Mouse) PR
Q5XIL5 Glb1l3 Beta-galactosidase-1-like protein 3 Rattus norvegicus (Rat) PR
Q9SCU8 BGAL14 Beta-galactosidase 14 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MLRVPLCTPL PLLALLQLLG AAHGIYNVTQ RTFKLDYSRD RFLKDGQPFR YISGSIHYFR
70 80 90 100 110 120
IPRFYWEDRL LKMKMAGLNA IQMYVPWNFH EPQPGQYEFS GDRDVEHFIQ LAHELGLLVI
130 140 150 160 170 180
LRPGPYICAE WDMGGLPAWL LEKQSIVLRS SDPDYLVAVD KWLAVLLPKM KPLLYQNGGP
190 200 210 220 230 240
IITVQVENEY GSYFACDYDY LRFLVHRFRY HLGNDVILFT TDGASEKMLK CGTLQDLYAT
250 260 270 280 290 300
VDFGTGNNIT QAFLVQRKFE PKGPLINSEF YTGWLDHWGK PHSTVKTKTL ATSLYNLLAR
310 320 330 340 350 360
GANVNLYMFI GGTNFAYWNG ANTPYEPQPT SYDYDAPLSE AGDLTKKYFA LREVIQMFKE
370 380 390 400 410 420
VPEGPIPPST PKFAYGKVAL RKFKTVAEAL GILCPNGPVK SLYPLTFTQV KQYFGYVLYR
430 440 450 460 470 480
TTLPQDCSNP KPIFSSPFNG VRDRAYVSVD GVPQGILDRN LMTALNIRGK AGATLDILVE
490 500 510 520 530 540
NMGRVNYGRF INDFKGLISN MTINSTVLTN WTVFPLNTEA MVRNHLWGRE ASDEGHLDGR
550 560 570 580 590 600
STSNSSDLIL PTFYVGNFSI PSGIPDLPQD TFIQFPGWSK GQVWINGFNL GRYWPTMGPQ
610 620 630 640
KTLFVPRNIL TTSAPNNITV LELEFAPCSE GTPELCTVEF VDTPVIS