O19015

PR
Gene name
GLB1 (BGAL)
Protein name
Beta-galactosidase
Names
Acid beta-galactosidase, Lactase
Species
Felis catus (Cat) (Felis silvestris catus)
KEGG Pathway
fca:493927
EC number
3.2.1.23: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O19015

Entry ID Method Resolution Chain Position Source
AF-O19015-F1 Predicted AlphaFoldDB

No variants for O19015

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O19015

No associated diseases with O19015

3 regional properties for O19015

Type Name Position InterPro Accession
conserved_site Glycoside hydrolase, family 35, conserved site 178 - 190 IPR019801
domain Beta-galactosidase jelly roll domain 531 - 621 IPR025300
domain Glycoside hydrolase 35, catalytic domain 42 - 357 IPR031330

Functions

Description
EC Number 3.2.1.23 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Lysosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

1 GO annotations of molecular function

Name Definition
beta-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.

1 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9TRY9 GLB1 Beta-galactosidase Canis lupus familiaris (Dog) (Canis familiaris) PR
A2RSQ1 Glb1l3 Beta-galactosidase-1-like protein 3 Mus musculus (Mouse) PR
P23780 Glb1 Beta-galactosidase Mus musculus (Mouse) PR
Q5XIL5 Glb1l3 Beta-galactosidase-1-like protein 3 Rattus norvegicus (Rat) PR
Q9SCU8 BGAL14 Beta-galactosidase 14 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDFPGAARLL SLLLVPLLLG PARGLRNASQ RTFKIDYGHN RFLKDGQPFR YISGSIHYFR
70 80 90 100 110 120
VPRFYWKDRL LKMKMAGLNA IQTYVPWNFH EPQPGQYQFS GEHDVEYFLK LAHELGLLVI
130 140 150 160 170 180
LRPGPYICAE WDMGGLPAWL LLKESIILRS SDPDYLAAVD KWLGVLLPKM KPLLYQNGGP
190 200 210 220 230 240
IITVQVENEY GSYFTCDYDY LRFLQRRFRD HLGGDVLLFT TDGAHEKFLQ CGALQGIYAT
250 260 270 280 290 300
VDFGPDANIT AAFQIQRKSE PRGPLVNSEF YTGWLDHWGQ PHSRVRTEVV ASSLHDVLAH
310 320 330 340 350 360
GANVNLYMFI GGTNFAYWNG ANIPYQPQPT SYDYDAPLSE AGDLTDKYFA LRDVIRKFEK
370 380 390 400 410 420
VPEGFIPPST PKFAYGKVAL QKLKTVEDAL NVLCPAGPIK SLYPLTFIQV KQYFGFVLYR
430 440 450 460 470 480
TTLPQDCSNP TPLSSPLNGV RDRAYVAVDG VPQGVLERSY VITLNITGQA GATLDLLVEN
490 500 510 520 530 540
MGRVNYGRYI NDFKGLISNL TLGSSVLTDW MIFPLDTEDA VRSHLGGWHG RNHGRQDNKA
550 560 570 580 590 600
FAHHSSNYTL PAFYAGNFSI PSGIPDLPQD TFIQFSGWTK GQVWINGFNL GRYWPGRGPQ
610 620 630 640 650 660
VTLFVPRHIL VTSAPNTIMV LELERAPCDD NGPELCTVEF VDRPLISATP TSSHPLPDLS
DRDSGWDRV