P10630
PR
Gene name |
Eif4a2 (Ddx2b) |
Protein name |
Eukaryotic initiation factor 4A-II |
Names |
eIF-4A-II, eIF4A-II, ATP-dependent RNA helicase eIF4A-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13682 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P10630
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P10630-F1 | Predicted | AlphaFoldDB |
11 variants for P10630
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389325279 | 19 | D>Y | No | EVA | |
| rs3389377993 | 20 | P>L | No | EVA | |
| rs3389399469 | 25 | E>G | No | EVA | |
| rs3389407684 | 46 | R>Q | No | EVA | |
| rs3389419329 | 99 | F>I | No | EVA | |
| rs3389412174 | 177 | I>F | No | EVA | |
| rs3389406662 | 188 | M>V | No | EVA | |
| rs3389402460 | 190 | S>N | No | EVA | |
| rs3389424708 | 194 | K>* | No | EVA | |
| rs3389402469 | 383 | R>K | No | EVA | |
| rs3389410055 | 396 | V>A | No | EVA |
No associated diseases with P10630
6 regional properties for P10630
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 181 - 189 | IPR000629 |
| domain | Helicase, C-terminal | 246 - 407 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 58 - 222 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 52 - 250 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 33 - 61 | IPR014014 |
| domain | ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain | 35 - 236 | IPR044728 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| eukaryotic translation initiation factor 4F complex | The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to leukemia inhibitory factor | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. |
| cytoplasmic translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
| negative regulation of RNA-directed 5'-3' RNA polymerase activity | Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity. |
| translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41378 | Eukaryotic initiation factor 4A | Triticum aestivum (Wheat) | PR | |
| P10081 | TIF2 | ATP-dependent RNA helicase eIF4A | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SZ54 | EIF4A1 | Eukaryotic initiation factor 4A-I | Bos taurus (Bovine) | PR |
| Q3SZ65 | EIF4A2 | Eukaryotic initiation factor 4A-II | Bos taurus (Bovine) | PR |
| Q8JFP1 | EIF4A2 | Eukaryotic initiation factor 4A-II | Gallus gallus (Chicken) | PR |
| A5A6N4 | EIF4A1 | Eukaryotic initiation factor 4A-I | Pan troglodytes (Chimpanzee) | PR |
| P60842 | EIF4A1 | Eukaryotic initiation factor 4A-I | Homo sapiens (Human) | PR |
| Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | Homo sapiens (Human) | PR |
| Q41741 | Eukaryotic initiation factor 4A | Zea mays (Maize) | PR | |
| Q6ZPL9 | Ddx55 | ATP-dependent RNA helicase DDX55 | Mus musculus (Mouse) | PR |
| P60843 | Eif4a1 | Eukaryotic initiation factor 4A-I | Mus musculus (Mouse) | PR |
| Q4FZF3 | Ddx49 | Probable ATP-dependent RNA helicase DDX49 | Mus musculus (Mouse) | PR |
| Q8K363 | Ddx18 | ATP-dependent RNA helicase DDX18 | Mus musculus (Mouse) | PR |
| Q9CWX9 | Ddx47 | Probable ATP-dependent RNA helicase DDX47 | Mus musculus (Mouse) | PR |
| Q8K4L0 | Ddx54 | ATP-dependent RNA helicase DDX54 | Mus musculus (Mouse) | PR |
| Q9ESV0 | Ddx24 | ATP-dependent RNA helicase DDX24 | Mus musculus (Mouse) | PR |
| Q91VR5 | Ddx1 | ATP-dependent RNA helicase DDX1 | Mus musculus (Mouse) | PR |
| Q9CWT6 | Ddx28 | Probable ATP-dependent RNA helicase DDX28 | Mus musculus (Mouse) | PR |
| Q569Z5 | Ddx46 | Probable ATP-dependent RNA helicase DDX46 | Mus musculus (Mouse) | PR |
| Q5RKI1 | Eif4a2 | Eukaryotic initiation factor 4A-II | Rattus norvegicus (Rat) | PR |
| Q6Z2Z4 | Os02g0146600 | Eukaryotic initiation factor 4A-3 | Oryza sativa subsp japonica (Rice) | PR |
| P35683 | Os06g0701100 | Eukaryotic initiation factor 4A-1 | Oryza sativa subsp japonica (Rice) | PR |
| P27639 | inf-1 | Eukaryotic initiation factor 4A | Caenorhabditis elegans | PR |
| Q3E9C3 | RH58 | DEAD-box ATP-dependent RNA helicase 58, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CAI7 | TIF4A-3 | Eukaryotic initiation factor 4A-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41376 | EIF4A1 | Eukaryotic initiation factor 4A-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41377 | TIF4A-2 | Eukaryotic initiation factor 4A-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGGSADYNR | EHGGPEGMDP | DGVIESNWNE | IVDNFDDMNL | KESLLRGIYA | YGFEKPSAIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QRAIIPCIKG | YDVIAQAQSG | TGKTATFAIS | ILQQLEIEFK | ETQALVLAPT | RELAQQIQKV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILALGDYMGA | TCHACIGGTN | VRNEMQKLQA | EAPHIVVGTP | GRVFDMLNRR | YLSPKWIKMF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLDEADEMLS | RGFKDQIYEI | FQKLNTSIQV | VLLSATMPTD | VLEVTKKFMR | DPIRILVKKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELTLEGIKQF | YINVEREEWK | LDTLCDLYET | LTITQAVIFL | NTRRKVDWLT | EKMHARDFTV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SALHGDMDQK | ERDVIMREFR | SGSSRVLITT | DLLARGIDVQ | QVSLVINYDL | PTNRENYIHR |
| 370 | 380 | 390 | 400 | ||
| IGRGGRFGRK | GVAINFVTEE | DKRILRDIET | FYNTTVEEMP | MNVADLI |