Q4FZF3

PR
Gene name
Ddx49
Protein name
Probable ATP-dependent RNA helicase DDX49
Names
DEAD box protein 49
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:234374
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

351-480 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4FZF3

Entry ID Method Resolution Chain Position Source
AF-Q4FZF3-F1 Predicted AlphaFoldDB

24 variants for Q4FZF3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388991866 9 L>* No EVA
rs3388939771 24 Q>H No EVA
rs3388984466 26 T>A No EVA
rs3388939737 40 R>Q No EVA
rs3388991617 48 T>K No EVA
rs3388963179 55 A>V No EVA
rs3399231990 77 T>S No EVA
rs3388991668 89 Q>* No EVA
rs3388988198 99 L>V No EVA
rs3388975278 115 L>Q No EVA
rs3399309685 132 A>V No EVA
rs49343197 135 L>V No EVA
rs3388957114 148 F>I No EVA
rs3388984678 160 Q>* No EVA
rs248383026 176 V>I No EVA
rs3388988236 195 E>K No EVA
rs3388988277 206 F>V No EVA
rs3412117927 225 L>S No EVA
rs3388969275 235 L>P No EVA
rs3399222083 243 Q>K No EVA
rs3399209494 244 D>E No EVA
rs3388988084 346 G>E No EVA
rs260494366 452 R>L No EVA
rs3388963105 459 T>I No EVA

No associated diseases with Q4FZF3

1 regional properties for Q4FZF3

Type Name Position InterPro Accession
repeat Leucine-rich repeat 89 - 110 IPR001611

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
positive regulation of cell growth Any process that activates or increases the frequency, rate, extent or direction of cell growth.
regulation of rRNA stability Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y6V7 DDX49 Probable ATP-dependent RNA helicase DDX49 Homo sapiens (Human) PR
Q8K363 Ddx18 ATP-dependent RNA helicase DDX18 Mus musculus (Mouse) PR
Q8K4L0 Ddx54 ATP-dependent RNA helicase DDX54 Mus musculus (Mouse) PR
Q9CWX9 Ddx47 Probable ATP-dependent RNA helicase DDX47 Mus musculus (Mouse) PR
Q9CWT6 Ddx28 Probable ATP-dependent RNA helicase DDX28 Mus musculus (Mouse) PR
Q91VR5 Ddx1 ATP-dependent RNA helicase DDX1 Mus musculus (Mouse) PR
Q6ZPL9 Ddx55 ATP-dependent RNA helicase DDX55 Mus musculus (Mouse) PR
Q9ESV0 Ddx24 ATP-dependent RNA helicase DDX24 Mus musculus (Mouse) PR
P60843 Eif4a1 Eukaryotic initiation factor 4A-I Mus musculus (Mouse) PR
P10630 Eif4a2 Eukaryotic initiation factor 4A-II Mus musculus (Mouse) PR
Q569Z5 Ddx46 Probable ATP-dependent RNA helicase DDX46 Mus musculus (Mouse) PR
Q8L4E9 Os07g0633500 DEAD-box ATP-dependent RNA helicase 36 Oryza sativa subsp japonica (Rice) PR
Q9FZ92 RH44 Putative DEAD-box ATP-dependent RNA helicase 44 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SA27 RH36 DEAD-box ATP-dependent RNA helicase 36 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAGFAEIGLS SWLVEQCRQL GLKQPTPVQL GCIPAILEGR DCLGCAKTGS GKTAAFVLPI
70 80 90 100 110 120
LQKLSEDPYG IFCLVLTPTR ELAYQIAEQF RVLGKPLGLK DCIIVGGMDM VAQALELSRK
130 140 150 160 170 180
PHVVIATPGR LADHLRSSNT FNMKKIQFLV MDEADRLLEQ GCTDFTTDLE TILAAVPARR
190 200 210 220 230 240
QTLLFSATLT DTLKELQGLA TNEPFFWEAQ ATVRTVEQLD QRYLLVPEKV KDAYLVHLVQ
250 260 270 280 290 300
TFQDQLEDCS IIIFTNTCKT CQILCMMLRK FNFPTVALHS MMKQKERFAA LAKFKSSIYR
310 320 330 340 350 360
ILIATDVASR GLDIPTVQVV INHNTPGLPK IYIHRVGRTA RAGRQGQAIT LVTQYDIHLL
370 380 390 400 410 420
HAIEEQIKQQ LAELVVEEAE VLQILTQVNV VRRECEIKLE ASHFDEKKEI NKRKQMILEG
430 440 450 460 470
KDPDLEAKRK AELAKIKQQN RRFKEKVGQT LRRQKAGSTV RRSRPPRSRP QEPAQAEAQD