Q3SZ54

PR
Gene name
EIF4A1
Protein name
Eukaryotic initiation factor 4A-I
Names
eIF-4A-I, eIF4A-I, ATP-dependent RNA helicase eIF4A-1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:504958
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SZ54

Entry ID Method Resolution Chain Position Source
AF-Q3SZ54-F1 Predicted AlphaFoldDB

31 variants for Q3SZ54

Variant ID(s) Position Change Description Diseaes Association Provenance
rs469235814 59 Q>K No EVA
rs479749746 63 I>F No EVA
rs465439241 64 L>H No EVA
rs445325023 64 L>V No EVA
rs437189649 65 P>R No EVA
rs457044257 73 I>L No EVA
rs467262082 79 G>A No EVA
rs441935224 219 D>G No EVA
rs462293617 226 K>N No EVA
rs472658134 228 M>V No EVA
rs441412833 229 R>S No EVA
rs458262028 230 D>V No EVA
rs439263052 238 K>E No EVA
rs462622797 243 L>P No EVA
rs482628810 244 E>* No EVA
rs448044577 246 I>L No EVA
rs472746406 261 D>G No EVA
rs441473309 262 T>S No EVA
rs472083595 343 L>F No EVA
rs443796161 346 N>T No EVA
rs457519904 348 D>G No EVA
rs466068476 365 R>H No EVA
rs445180497 366 F>L No EVA
rs437477449 369 K>T No EVA
rs474420310 371 V>G No EVA
rs436551764 379 E>G No EVA
rs455439910 382 R>T No EVA
rs440842892 389 T>S No EVA
rs457729272 400 L>H No EVA
rs443464032 404 D>G No EVA
rs463454515 407 I>R No EVA

No associated diseases with Q3SZ54

4 regional properties for Q3SZ54

Type Name Position InterPro Accession
domain Arf GTPase activating protein 405 - 527 IPR001164
domain Pleckstrin homology domain 265 - 362 IPR001849
repeat Ankyrin repeat 607 - 707 IPR002110
domain BAR domain 5 - 238 IPR004148

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
double-stranded RNA binding Binding to double-stranded RNA.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41378 Eukaryotic initiation factor 4A Triticum aestivum (Wheat) PR
P10081 TIF2 ATP-dependent RNA helicase eIF4A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3SZ65 EIF4A2 Eukaryotic initiation factor 4A-II Bos taurus (Bovine) PR
Q29S22 DDX47 Probable ATP-dependent RNA helicase DDX47 Bos taurus (Bovine) PR
Q3SZ40 DDX56 Probable ATP-dependent RNA helicase DDX56 Bos taurus (Bovine) PR
Q2NL08 DDX55 ATP-dependent RNA helicase DDX55 Bos taurus (Bovine) PR
Q8JFP1 EIF4A2 Eukaryotic initiation factor 4A-II Gallus gallus (Chicken) PR
A5A6N4 EIF4A1 Eukaryotic initiation factor 4A-I Pan troglodytes (Chimpanzee) PR
Q14240 EIF4A2 Eukaryotic initiation factor 4A-II Homo sapiens (Human) PR
P60842 EIF4A1 Eukaryotic initiation factor 4A-I Homo sapiens (Human) PR
Q41741 Eukaryotic initiation factor 4A Zea mays (Maize) PR
P10630 Eif4a2 Eukaryotic initiation factor 4A-II Mus musculus (Mouse) PR
P60843 Eif4a1 Eukaryotic initiation factor 4A-I Mus musculus (Mouse) PR
Q5RKI1 Eif4a2 Eukaryotic initiation factor 4A-II Rattus norvegicus (Rat) PR
P35683 Os06g0701100 Eukaryotic initiation factor 4A-1 Oryza sativa subsp japonica (Rice) PR
Q6Z2Z4 Os02g0146600 Eukaryotic initiation factor 4A-3 Oryza sativa subsp japonica (Rice) PR
P27639 inf-1 Eukaryotic initiation factor 4A Caenorhabditis elegans PR
Q3E9C3 RH58 DEAD-box ATP-dependent RNA helicase 58, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAI7 TIF4A-3 Eukaryotic initiation factor 4A-3 Arabidopsis thaliana (Mouse-ear cress) PR
P41377 TIF4A-2 Eukaryotic initiation factor 4A-2 Arabidopsis thaliana (Mouse-ear cress) PR
P41376 EIF4A1 Eukaryotic initiation factor 4A-1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSASQDSRSR DNGPDGMEPE GVIESNWNEI VDSFDDMNLS ESLLRGIYAY GFEKPSAIQQ
70 80 90 100 110 120
RAILPCIKGY DVIAQAQSGT GKTATFAISI LQQIELDLKA TQALVLAPTR ELAQQIQKVV
130 140 150 160 170 180
MALGDYMGAS CHACIGGTNV RAEVQKLQME APHIIVGTPG RVFDMLNRRY LSPKYIKMFV
190 200 210 220 230 240
LDEADEMLSR GFKDQIYDIF QKLNSNTQVV LLSATMPSDV LEVTKKFMRD PIRILVKKEE
250 260 270 280 290 300
LTLEGIRQFY INVEREEWKL DTLCDLYETL TITQAVIFIN TRRKVDWLTE KMHARDFTVS
310 320 330 340 350 360
AMHGDMDQKE RDVIMREFRS GSSRVLITTD LLARGIDVQQ VSLVINYDLP TNRENYIHRI
370 380 390 400
GRGGRFGRKG VAINMVTEED KRTLRDIETF YNTSIEEMPL NVADLI