P0CW70

PR
Gene name
Dpy19l2
Protein name
Probable C-mannosyltransferase DPY19L2
Names
Dpy-19-like protein 2, Protein dpy-19 homolog 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:320752
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-78 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CW70

Entry ID Method Resolution Chain Position Source
AF-P0CW70-F1 Predicted AlphaFoldDB

26 variants for P0CW70

Variant ID(s) Position Change Description Diseaes Association Provenance
rs38305944 39 E>D No EVA
rs224611338 47 T>R No EVA
rs39098064 59 G>S No EVA
rs3389032904 80 Q>H No EVA
rs3389029324 146 D>V No EVA
rs3388978851 169 Y>C No EVA
rs3412846101 193 L>I No EVA
rs3389023420 299 N>I No EVA
rs3389029587 318 Y>F No EVA
rs233256695 327 I>V No EVA
rs1135290393 346 C>R No EVA
rs3389035781 359 A>V No EVA
rs3389005840 363 L>F No EVA
rs3389019268 440 F>C No EVA
rs3389023498 449 W>* No EVA
rs3389029363 452 T>A No EVA
rs3399910948 484 D>E No EVA
rs3399897675 484 D>N No EVA
rs3399357824 485 F>S No EVA
rs3389005866 659 M>I No EVA
rs3388978836 659 M>T No EVA
rs3389032914 693 S>T No EVA
rs3388978818 746 L>F No EVA
rs3399691277 766 M>I No EVA
rs3389009648 767 Y>* No EVA
rs3389029575 771 K>R No EVA

No associated diseases with P0CW70

3 regional properties for P0CW70

Type Name Position InterPro Accession
domain Zinc finger, ZZ-type 222 - 279 IPR000433
domain EF-hand domain, type 1 8 - 118 IPR015153
domain EF-hand domain, type 2 124 - 217 IPR015154

Functions

Description
EC Number
Subcellular Localization
  • Nucleus inner membrane ; Multi-pass membrane protein
  • Restricted to the inner nuclear membrane facing the acrosomal vesicle
  • The N- and C-termini are oriented towards the nucleoplasm (PubMed:22764053)
  • Colocalizes with FAM209 at the inner nuclear membrane (PubMed:34471926)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.

1 GO annotations of molecular function

Name Definition
mannosyltransferase activity Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

2 GO annotations of biological process

Name Definition
protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring.
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7Z388 DPY19L4 Probable C-mannosyltransferase DPY19L4 Homo sapiens (Human) PR
Q6NUT2 DPY19L2 Probable C-mannosyltransferase DPY19L2 Homo sapiens (Human) PR
A2AJQ3 Dpy19l4 Probable C-mannosyltransferase DPY19L4 Mus musculus (Mouse) PR
A6X919 Dpy19l1 Probable C-mannosyltransferase DPY19L1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MVGPTRSKLR EGSSDRPQSS CTGQARRRWS AATMEPQQER SAPQERTKWS LLQHFLLGGR
70 80 90 100 110 120
KLPSGARNYA ARRIQSLNAQ NYFQLEEVAK LLLLNRFQFL FTLLDHFREK VQALQMHRFS
130 140 150 160 170 180
HRTLFGLAIF VGILHWLHLI TLFENDHHFS HLSSLEREMT FRTEMGLYYS YFKTIIEAPS
190 200 210 220 230 240
FLEGLWMIMN DRLTEYPLVI NTVKRFHLYP EVVIAYWYRT IIGIMNLFGI ETKTCWNVTR
250 260 270 280 290 300
MEPLNEVQSC EGLGDPACFY IGVIFILNGL MMGLFFIYST YLSGSQLGGL ITVACYFFNH
310 320 330 340 350 360
GEATRVMWTP PLRESFSYPF LVLQMYILTI ILRTSTVHKK HYMALCFSNV AFMLPWQFAQ
370 380 390 400 410 420
FILFTQIASL FPMYVVGYIE PSKFQKIIYV NMSSVALCFI LMFGNSMYLS SYYSSCLLVT
430 440 450 460 470 480
WAIMQKKSKI QKLGGTELQF WLIQGCFWWC GTIILKFLTS KICGVSDHIR LSDLIAARIL
490 500 510 520 530 540
RYTDFDTLIY TCAPEFDFME QATPLRYIKT LLLPLILVIT YLIFKKIVRD IMCVLYTNTY
550 560 570 580 590 600
VRKQLLDNAE LIFHTLQLLA FTGLAILIMR LKLFLTPHMC IMASLICSQR LFGWLFCRIH
610 620 630 640 650 660
FENVVFGILT MMSIQGCANL HNQWSIMGEF TNLPQEELIH WIKHSTRPDA VFAGAMPTMA
670 680 690 700 710 720
SIKLSTLRPI VNHPHYEDAD LRARTKIVYS VYSRKSAVEV RNNLLKLHVN YYVLEEAWCV
730 740 750 760 770
VRTKPGCSML EIWDVEDPSN AANPPLCSIL LKDSRPYFTT VFQNSMYRVL KIN