A2AJQ3
Gene name |
Dpy19l4 (Gm1023) |
Protein name |
Probable C-mannosyltransferase DPY19L4 |
Names |
Dpy-19-like protein 4, Protein dpy-19 homolog 4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:381510 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2AJQ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2AJQ3-F1 | Predicted | AlphaFoldDB |
24 variants for A2AJQ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388666380 | 20 | S>P | No | EVA | |
| rs3388677205 | 24 | E>D | No | EVA | |
| rs253695188 | 135 | Q>R | No | EVA | |
| rs3393946412 | 275 | S>C | No | EVA | |
| rs3388667691 | 278 | L>M | No | EVA | |
| rs213212638 | 324 | G>A | No | EVA | |
| rs3388677199 | 374 | N>S | No | EVA | |
| rs27731761 | 406 | A>V | No | EVA | |
| rs3388669681 | 418 | S>F | No | EVA | |
| rs3388666315 | 439 | F>L | No | EVA | |
| rs3388671936 | 443 | M>L | No | EVA | |
| rs3388661887 | 460 | G>E | No | EVA | |
| rs3388673798 | 466 | I>N | No | EVA | |
| rs3393950946 | 492 | Y>N | No | EVA | |
| rs3388677153 | 494 | C>* | No | EVA | |
| rs3388671297 | 496 | L>R* | No | EVA | |
| rs3388669685 | 584 | P>L | No | EVA | |
| rs3394074959 | 638 | N>KRSQNN* | No | EVA | |
| rs221625527 | 640 | L>V | No | EVA | |
| rs253860642 | 650 | L>M | No | EVA | |
| rs3388667674 | 655 | G>D | No | EVA | |
| rs3388669211 | 681 | K>N | No | EVA | |
| rs3388669749 | 704 | Y>* | No | EVA | |
| rs1135236850 | 723 | S>C | No | EVA |
No associated diseases with A2AJQ3
No regional properties for A2AJQ3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A2AJQ3 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mannosyltransferase activity | Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan | The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6NUT2 | DPY19L2 | Probable C-mannosyltransferase DPY19L2 | Homo sapiens (Human) | PR |
| Q7Z388 | DPY19L4 | Probable C-mannosyltransferase DPY19L4 | Homo sapiens (Human) | PR |
| P0CW70 | Dpy19l2 | Probable C-mannosyltransferase DPY19L2 | Mus musculus (Mouse) | PR |
| A6X919 | Dpy19l1 | Probable C-mannosyltransferase DPY19L1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKEEGTSVE | PRQRKKQRTS | GSQEAKAEKI | RRTPAPERAP | KYVSFQRFAK | IVIGCLAAVI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGMMHVFYLS | AYHERKFWFS | NRQELEREIT | FQGDSAIYYS | YYKDMLKAPS | FERGVYELTH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NNKTISLKTI | NAMQQMSLYP | ELIASVLYQA | TGSNEVIEPV | YFYIGIVFGL | QGMYVTALFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TSWLMSGTWL | AGMLTVAWFL | INRVDTTRIE | YSIPLRENWA | LPYFACQVAA | LTGYLKRNLN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TYAERFCYLL | LSTSTYTFMM | VWEYSHYVLF | LQAVSLLLLD | IFSVEQSDKV | YEVYKVYIFS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LFLGYLLQFE | NPALLVSPLL | SLVGAFMLVK | CLQLNGKKGT | FVAKVIKVFE | FYLLCTLPVT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LNLIVKMFVP | HKENEHVLKF | LEVKFGLNMT | KNFTLNWLLC | QESLQAPSQD | FFFRLTQSSL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LPFYVLVLII | CLLSMTQVFF | RRMSGKSKKE | TVTLEDGRIG | ERPEIIYHVI | HTLLLGSLAM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LMEGLKFIWT | PYVCMLAAFG | VCSPELWMTL | LKWLRLRTVH | PMLLALILSM | AVPTIIGLSL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WKEFFPRLIT | ELTELQEFYD | PDTVELMTWI | KRQAPVAAVF | AGSPQLMGVI | KLCTGWTVTS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LPLYSDDDLL | QRNENIYQIY | SKRSAEDIYK | ILTSYKANYL | IVEDAICNEL | GTTRGCRVKD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLDIANGHVV | FEEGDKLTYS | KYGRFCHEVK | INYSPYVNYF | TRVYWNRSYF | VYKVNTVISF |
| QS |