A6X919
Gene name |
Dpy19l1 |
Protein name |
Probable C-mannosyltransferase DPY19L1 |
Names |
Dpy-19-like protein 1, Protein dpy-19 homolog 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:244745 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6X919
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6X919-F1 | Predicted | AlphaFoldDB |
25 variants for A6X919
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389009665 | 211 | G>* | No | EVA | |
| rs3399896195 | 240 | L>I | No | EVA | |
| rs3389019269 | 286 | F>I | No | EVA | |
| rs3389032943 | 293 | L>Q | No | EVA | |
| rs3389036984 | 318 | S>T | No | EVA | |
| rs3389031810 | 331 | F>I | No | EVA | |
| rs37000541 | 367 | L>V | No | EVA | |
| rs220998161 | 490 | V>G | No | EVA | |
| rs239860637 | 497 | I>V | No | EVA | |
| rs222384321 | 504 | V>A | No | EVA | |
| rs3389009725 | 547 | T>A | No | EVA | |
| rs3389031758 | 563 | F>* | No | EVA | |
| rs3389019304 | 565 | W>G | No | EVA | |
| rs3389029501 | 593 | T>I | No | EVA | |
| rs3389023471 | 600 | E>D | No | EVA | |
| rs3389029524 | 600 | E>K | No | EVA | |
| rs3389029340 | 607 | E>* | No | EVA | |
| rs3389009704 | 644 | H>Q | No | EVA | |
| rs3389032921 | 648 | E>D | No | EVA | |
| rs3389029367 | 663 | Y>F | No | EVA | |
| rs38214250 | 669 | E>K | No | EVA | |
| rs3389019236 | 674 | E>D | No | EVA | |
| rs3389005862 | 687 | E>V | No | EVA | |
| rs37536930 | 736 | S>G | No | EVA | |
| rs216132562 | 744 | L>I | No | EVA |
No associated diseases with A6X919
No regional properties for A6X919
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A6X919 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mannosyltransferase activity | Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan | The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6NUT2 | DPY19L2 | Probable C-mannosyltransferase DPY19L2 | Homo sapiens (Human) | PR |
| Q7Z388 | DPY19L4 | Probable C-mannosyltransferase DPY19L4 | Homo sapiens (Human) | PR |
| A2AJQ3 | Dpy19l4 | Probable C-mannosyltransferase DPY19L4 | Mus musculus (Mouse) | PR |
| P0CW70 | Dpy19l2 | Probable C-mannosyltransferase DPY19L2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLQARSKHR | DAAPRPPRSA | RSSPPPLSGA | SEVDAGELGS | ERTPPSPGRR | GAAGRKGPRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GTAAPAPDGL | AGRLAAGLHW | ALGLRRGRGR | TWSTLLLASF | AALLHWSHIT | HLFENDRHFS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HLSTLEREMA | FRTEMGLYYS | YFKTIVEAPS | FLNGVWMIMN | DKLTEYPLVI | NTLKRFNLYP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVILASWYRI | YTKIMDLIGI | QTKICWTVTR | GEGLSPIESC | EGLGDPACFY | VAVIFMLNGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MMALFFIYGT | YLSGSRLGGV | VTVLCFFFNH | GECTRVMWTP | PLRESFSYPF | LVLQMLLVTH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ILRAPELCRG | SLIALCISNV | LFMLPWQFAQ | FVLLTQIASL | FAVYVVGYID | THKLQKIIYM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HMISLVLCFV | LMFGNSMLLT | SYYASSLVII | WGMLAMKPQF | LRMNVSELSL | WVIQGCGWLF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GTVILKSVTS | RIFGIADDAH | IGNLLTSKFF | SYKDFDTLLY | TCAAEFDFME | KETPLRYTKT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLLPVVLVTV | AAIVRKIFND | MRGVVAKQRT | HTRKQQFEHG | ELVYHALQLL | AYTALGVLIM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RLKLFLTPHM | CVMASLICSR | QLFGWLFGKV | HPGAVVFAIL | AAMSIQGSAN | LQTQWNIVGE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FSNLPQEELI | EWIRYSTKPD | AVFAGAMPTM | ASVKLSALRP | VVNHPHYEDA | GLRARTKIVY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SMYSRKAPED | VKKELMKLKV | NYYILEESWC | IRRSKPGCSM | PEIWDVEDPD | NAGKTPLCNI |
| 730 | 740 | ||||
| LVKDSKPHFT | TVFQNSVYKV | LEVLRQ |