P0A9Q1

PR
Gene name
arcA (cpxC, dye, fexA, msp, seg, sfrA)
Protein name
Aerobic respiration control protein ArcA
Names
Dye resistance protein
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b4401
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

87-160 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P0A9Q1

Entry ID Method Resolution Chain Position Source
1XHE X-ray 250 A A/B 1-123 PDB
1XHF X-ray 215 A A/B 1-123 PDB
AF-P0A9Q1-F1 Predicted AlphaFoldDB

No variants for P0A9Q1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0A9Q1

No associated diseases with P0A9Q1

2 regional properties for P0A9Q1

Type Name Position InterPro Accession
domain Signal transduction response regulator, receiver domain 4 - 118 IPR001789
domain OmpR/PhoB-type DNA-binding domain 134 - 234 IPR001867

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
protein-DNA complex A macromolecular complex containing both protein and DNA molecules.

6 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription repressor activity A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
identical protein binding Binding to an identical protein or proteins.
phosphorelay response regulator activity Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

4 GO annotations of biological process

Name Definition
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
phosphorelay signal transduction system A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P52108 rstA Transcriptional regulatory protein RstA Escherichia coli (strain K12) PR
P0AE88 cpxR Transcriptional regulatory protein CpxR Escherichia coli (strain K12) PR
10 20 30 40 50 60
MQTPHILIVE DELVTRNTLK SIFEAEGYDV FEATDGAEMH QILSEYDINL VIMDINLPGK
70 80 90 100 110 120
NGLLLARELR EQANVALMFL TGRDNEVDKI LGLEIGADDY ITKPFNPREL TIRARNLLSR
130 140 150 160 170 180
TMNLGTVSEE RRSVESYKFN GWELDINSRS LIGPDGEQYK LPRSEFRAML HFCENPGKIQ
190 200 210 220 230
SRAELLKKMT GRELKPHDRT VDVTIRRIRK HFESTPDTPE IIATIHGEGY RFCGDLED