Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P03987
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1CLZ | X-ray | 280 A | H | 1-99 | PDB |
| 2VQ1 | X-ray | 250 A | B/F | 1-99 | PDB |
| AF-P03987-F1 | Predicted | AlphaFoldDB |
No variants for P03987
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P03987 | |||||
No associated diseases with P03987
7 regional properties for P03987
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Immunoglobulin/major histocompatibility complex, conserved site | 305 - 311 | IPR003006 |
| domain | Immunoglobulin C1-set | 7 - 91 | IPR003597-1 |
| domain | Immunoglobulin C1-set | 122 - 213 | IPR003597-2 |
| domain | Immunoglobulin C1-set | 230 - 317 | IPR003597-3 |
| domain | Immunoglobulin-like domain | 5 - 97 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 120 - 219 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 228 - 324 | IPR007110-3 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| antigen binding | Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. |
| immunoglobulin receptor binding | Binding to one or more specific sites on an immunoglobulin receptor molecule. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of immune response | Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| TTTAPSVYPL | VPGCSDTSGS | SVTLGCLVKG | YFPEPVTVKW | NYGALSSGVR | TVSSVLQSGF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YSLSSLVTVP | SSTWPSQTVI | CNVAHPASKT | ELIKRIEPRI | PKPSTPPGSS | CPPGNILGGP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SVFIFPPKPK | DALMISLTPK | VTCVVVDVSE | DDPDVHVSWF | VDNKEVHTAW | TQPREAQYNS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TFRVVSALPI | QHQDWMRGKE | FKCKVNNKAL | PAPIERTISK | PKGRAQTPQV | YTIPPPREQM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SKKKVSLTCL | VTNFFSEAIS | VEWERNGELE | QDYKNTPPIL | DSDGTYFLYS | KLTVDTDSWL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QGEIFTCSVV | HEALHNHHTQ | KNLSRSPELE | LNETCAEAQD | GELDGLWTTI | TIFISLFLLS |
| 370 | 380 | 390 | |||
| VCYSASVTLF | KVKWIFSSVV | QVKQTAIPDY | RNMIGQGA |