P01878

PR
Gene name
Protein name
Ig alpha chain C region
Names
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-92 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P01878

Entry ID Method Resolution Chain Position Source
7JG1 EM 330 A A/B/C/D 1-344 PDB
7JG2 EM 330 A A/B/C/D 1-344 PDB
AF-P01878-F1 Predicted AlphaFoldDB

15 variants for P01878

Variant ID(s) Position Change Description Diseaes Association Provenance
2 S>A MOPC 47A [UniProt] No
18 S>C MOPC 47A and M511 [UniProt] No
67 N>S MOPC 47A and M511 [UniProt] No
73 A>T MOPC 47A [UniProt] No
112 P>G M511; requires 2 nucleotide substitutions [UniProt] No
135 S>Q MOPC 47A and M511; requires 2 nucleotide substitutions [UniProt] No
141 N>D MOPC 47A and M511 [UniProt] No
168 Q>E MOPC 47A [UniProt] No
212 V>SQ MOPC 47A [UniProt] No
235 E>G M511 [UniProt] No
255 W>del M511 [UniProt] No
295 T>D M511; requires 2 nucleotide substitutions [UniProt] No
301 Q>G M511; requires 2 nucleotide substitutions [UniProt] No
329 N>Q M511; requires 2 nucleotide substitutions [UniProt] No
331 S>N M511 [UniProt] No

No associated diseases with P01878

2 regional properties for P01878

Type Name Position InterPro Accession
domain Uracil-DNA glycosylase-like 47 - 205 IPR005122
active_site Uracil-DNA glycosylase, active site 55 - 64 IPR018085

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

2 GO annotations of molecular function

Name Definition
antigen binding Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
immunoglobulin receptor binding Binding to one or more specific sites on an immunoglobulin receptor molecule.

1 GO annotations of biological process

Name Definition
regulation of immune response Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P01882 Ig delta chain C region membrane-bound form Mus musculus (Mouse) PR
P03987 Ig gamma-3 chain C region Mus musculus (Mouse) PR
P01869 Ighg1 Ig gamma-1 chain C region, membrane-bound form Mus musculus (Mouse) PR
10 20 30 40 50 60
ESARNPTIYP LTLPPALSSD PVIIGCLIHD YFPSGTMNVT WGKSGKDITT VNFPPALASG
70 80 90 100 110 120
GRYTMSNQLT LPAVECPEGE SVKCSVQHDS NPVQELDVNC SGPTPPPPIT IPSCQPSLSL
130 140 150 160 170 180
QRPALEDLLL GSDASITCTL NGLRNPEGAV FTWEPSTGKD AVQKKAVQNS CGCYSVSSVL
190 200 210 220 230 240
PGCAERWNSG ASFKCTVTHP ESGTLTGTIA KVTVNTFPPQ VHLLPPPSEE LALNELLSLT
250 260 270 280 290 300
CLVRAFNPKE VLVRWLHGNE ELSPESYLVF EPLKEPGEGA TTYLVTSVLR VSAETWKQGD
310 320 330 340
QYSCMVGHEA LPMNFTQKTI DRLSGKPTNV SVSVIMSEGD GICY