P01869

PR
Gene name
Ighg1 (Igh-4)
Protein name
Ig gamma-1 chain C region, membrane-bound form
Names
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

19-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

29 structures for P01869

Entry ID Method Resolution Chain Position Source
15C8 X-ray 250 A H 1-98 PDB
1A0Q X-ray 230 A H 1-97 PDB
1A3L X-ray 195 A H 1-99 PDB
1ACY X-ray 300 A H 1-100 PDB
1AE6 X-ray 300 A H 1-98 PDB
1C12 X-ray 260 A B 1-99 PDB
1CIC X-ray 250 A D 1-102 PDB
1CK0 X-ray 250 A H 1-98 PDB
1CL7 X-ray 300 A I 21-102 PDB
1F11 X-ray 300 A B/D 1-102 PDB
1F58 X-ray 200 A H 1-102 PDB
1IGY X-ray 320 A B/D 1-320 PDB
1JRH X-ray 280 A H 1-97 PDB
1KC5 X-ray 250 A H 1-101 PDB
1KCR X-ray 290 A H 1-102 PDB
1KCU X-ray 220 A H 1-101 PDB
1KEN X-ray 350 A H/T 1-101 PDB
1ORS X-ray 190 A B 1-103 PDB
1QFU X-ray 280 A H 1-101 PDB
1S5I X-ray 270 A H 1-102 PDB
25C8 X-ray 200 A H 1-98 PDB
2AJS X-ray 170 A H 1-100 PDB
2AJU X-ray 150 A H 1-100 PDB
2AJV X-ray 150 A H 1-100 PDB
2AJX X-ray 185 A H 1-100 PDB
2AJY X-ray 210 A H 1-100 PDB
2AJZ X-ray 230 A B/H 1-100 PDB
2AK1 X-ray 185 A H 1-100 PDB
AF-P01869-F1 Predicted AlphaFoldDB

No variants for P01869

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P01869

No associated diseases with P01869

6 regional properties for P01869

Type Name Position InterPro Accession
domain Immunoglobulin C1-set 8 - 92 IPR003597-1
domain Immunoglobulin C1-set 117 - 203 IPR003597-2
domain Immunoglobulin C1-set 225 - 312 IPR003597-3
domain Immunoglobulin-like domain 6 - 98 IPR007110-1
domain Immunoglobulin-like domain 112 - 214 IPR007110-2
domain Immunoglobulin-like domain 223 - 319 IPR007110-3

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
IgG immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
immunoglobulin complex, circulating An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
antigen binding Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
Fc-gamma receptor I complex binding Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.
immunoglobulin receptor binding Binding to one or more specific sites on an immunoglobulin receptor molecule.

16 GO annotations of biological process

Name Definition
antibacterial humoral response An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
antibody-dependent cellular cytotoxicity Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.
B cell differentiation The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
B cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
complement activation, classical pathway Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
humoral immune response mediated by circulating immunoglobulin An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
immunoglobulin mediated immune response An immune response mediated by immunoglobulins, whether cell-bound or in solution.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
phagocytosis, engulfment The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
phagocytosis, recognition The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell.
positive regulation of B cell activation Any process that activates or increases the frequency, rate or extent of B cell activation.
positive regulation of immune response Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of phagocytosis Any process that activates or increases the frequency, rate or extent of phagocytosis.
positive regulation of type I hypersensitivity Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.
positive regulation of type IIa hypersensitivity Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P01882 Ig delta chain C region membrane-bound form Mus musculus (Mouse) PR
P01878 Ig alpha chain C region Mus musculus (Mouse) PR
P03987 Ig gamma-3 chain C region Mus musculus (Mouse) PR
10 20 30 40 50 60
AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV HTFPAVLQSD
70 80 90 100 110 120
LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR DCGCKPCICT VPEVSSVFIF
130 140 150 160 170 180
PPKPKDVLTI TLTPKVTCVV VDISKDDPEV QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV
190 200 210 220 230 240
SELPIMHQDW LNGKEFKCRV NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV
250 260 270 280 290 300
SLTCMITDFF PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF
310 320 330 340 350 360
TCSVLHEGLH NHHTEKSLSH SPGLQLDETC AEAQDGELDG LWTTITIFIS LFLLSVCYSA
370 380 390
AVTLFKVKWI FSSVVELKQT LVPEYKNMIG QAP