O88632
PR
Gene name |
Sema3f |
Protein name |
Semaphorin-3F |
Names |
Semaphorin IV, Sema IV |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20350 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O88632
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O88632-F1 | Predicted | AlphaFoldDB |
45 variants for O88632
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389045894 | 7 | I>N | No | EVA | |
| rs213250981 | 20 | T>I | No | EVA | |
| rs3413041662 | 44 | T>I | No | EVA | |
| rs3389071158 | 49 | N>T | No | EVA | |
| rs3389068404 | 58 | R>T | No | EVA | |
| rs3400085860 | 62 | K>M | No | EVA | |
| rs3389068345 | 62 | K>N | No | EVA | |
| rs3389050806 | 119 | V>I | No | EVA | |
| rs3389016611 | 155 | P>A | No | EVA | |
| rs3389038341 | 160 | Q>E | No | EVA | |
| rs3389045896 | 172 | G>D | No | EVA | |
| rs3389073990 | 194 | L>M | No | EVA | |
| rs3389038354 | 204 | D>G | No | EVA | |
| rs3389068400 | 219 | Y>* | No | EVA | |
| rs3389069354 | 275 | L>V | No | EVA | |
| rs3389081081 | 276 | Y>H | No | EVA | |
| rs3389058707 | 278 | F>V | No | EVA | |
| rs3400893509 | 289 | N>H | No | EVA | |
| rs3389068385 | 294 | A>V | No | EVA | |
| rs33272301 | 350 | V>I | No | EVA | |
| rs3389058710 | 371 | V>M | No | EVA | |
| rs3389016534 | 396 | Q>L | No | EVA | |
| rs3389070979 | 433 | N>K | No | EVA | |
| rs3389070959 | 474 | A>G | No | EVA | |
| rs3389071164 | 498 | K>N | No | EVA | |
| rs256591340 | 524 | T>A | No | EVA | |
| rs3389064647 | 531 | Q>H | No | EVA | |
| rs3389073957 | 568 | W>L | No | EVA | |
| rs3389075664 | 574 | S>F | No | EVA | |
| rs33270737 | 621 | A>T | No | EVA | |
| rs3400696411 | 655 | R>L | No | EVA | |
| rs3389069283 | 659 | T>S | No | EVA | |
| rs3389016541 | 668 | L>V | No | EVA | |
| rs3400653471 | 684 | N>I | No | EVA | |
| rs30288026 | 700 | D>E | No | EVA | |
| rs3400554372 | 709 | P>H | No | EVA | |
| rs3400642597 | 712 | V>M | No | EVA | |
| rs3400743274 | 714 | V>I | No | EVA | |
| rs3389075588 | 722 | P>S | No | EVA | |
| rs3389081082 | 735 | A>T | No | EVA | |
| rs3389071169 | 742 | I>T | No | EVA | |
| rs3400626085 | 743 | H>R | No | EVA | |
| rs3399556083 | 751 | R>H | No | EVA | |
| rs13465457 | 756 | R>S | No | EVA | |
| rs3389016575 | 772 | Q>H | No | EVA |
No associated diseases with O88632
5 regional properties for O88632
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chemorepellent activity | Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. |
| semaphorin receptor binding | Binding to a semaphorin receptor. |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| axon extension involved in axon guidance | The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| branchiomotor neuron axon guidance | The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. |
| facial nerve structural organization | The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. |
| locomotion | Self-propelled movement of a cell or organism from one location to another. |
| negative chemotaxis | The directed movement of a motile cell or organism towards a lower concentration of a chemical. |
| negative regulation of axon extension involved in axon guidance | Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. |
| nerve development | The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. |
| neural crest cell migration | The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. |
| neural crest cell migration involved in autonomic nervous system development | Any neural crest cell migration that is involved in autonomic nervous system development. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| regulation of postsynapse organization | Any process that modulates the physical form of a postsynapse. |
| semaphorin-plexin signaling pathway | The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. |
| semaphorin-plexin signaling pathway involved in axon guidance | Any semaphorin-plexin signaling pathway that is involved in axon guidance. |
| semaphorin-plexin signaling pathway involved in neuron projection guidance | Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance. |
| sympathetic ganglion development | The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. |
| sympathetic neuron projection extension | Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| sympathetic neuron projection guidance | The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. |
| trigeminal nerve structural organization | The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. |
| trunk neural crest cell migration | The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo. |
| ventral trunk neural crest cell migration | The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLVTAFILWA | SLLTGAWPAT | PIQDQLPATP | RVRLSFKELK | ATGTAHFFNF | LLNTTDYRIL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKDEDHDRMY | VGSKDYVLSL | DLHDINREPL | IIHWAASPQR | IEECILSGKD | GNGECGNFVR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LIQPWNRTHL | YVCGTGAYNP | MCTYVNRGRR | AQALPWTQMQ | VVRGRGSRAT | DGADRPTPTA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PRQDYIFYLE | PEKLESGKGK | CPYDPKLDTA | SALINEELYA | GVYIDFMGTD | AAIFRTLGKQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TAMRTDQYNS | RWLNDPSFIH | AELIPDSAER | NDDKLYFFFR | ERSAEAPQNP | AVYARIGRIC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LNDDGGHCCL | VNKWSTFLKA | RLVCSVPGED | GIETHFDELQ | DVFVQQTQDV | RNPVIYAVFT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSGSVFRGSA | VCVYSMADIR | MVFNGPFAHK | EGPNYQWMPF | SGKMPYPRPG | TCPGGTFTPS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MKSTKDYPDE | VINFMRTHPL | MYQAVYPLQR | RPLVVRTGAP | YRLTTVAVDQ | VDAADGRYEV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LFLGTDRGTV | QKVIVLPKDD | QEVEELMLEE | VEVFKEPAPV | KTMTISSKRQ | QLYVASAVGV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| THLSLHRCQA | YGAACADCCL | ARDPYCAWDG | QACSRYTASS | KRRSRRQDVR | HGNPIRQCRG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FNSNANKNAV | ESVQYGVAGS | AAFLECQPRS | PQATVKWLFQ | RDPSDRRREI | RAEDRFLRTE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QGLLLRALQL | GDRGLYSCTA | TENNFKHIVT | RVQLHVLGRD | AVHAALFPPL | AVSVPPPPGT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GPPTPPYQEL | AQLLAQPEVG | LIHQYCQGYW | RHVPPRPREA | PGALRPPELQ | DQKKPRNRRH |
| HPPDT |