A7MB70
PR
Gene name |
SEMA3C |
Protein name |
Semaphorin-3C |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:512660 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A7MB70
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A7MB70-F1 | Predicted | AlphaFoldDB |
64 variants for A7MB70
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs43383171 | 17 | T>P | No | EVA | |
| rs456415533 | 33 | F>I | No | EVA | |
| rs443106971 | 40 | K>* | No | EVA | |
| rs473398995 | 40 | K>N | No | EVA | |
| rs453449613 | 40 | K>T | No | EVA | |
| rs483186026 | 101 | C>G | No | EVA | |
| rs448811707 | 107 | D>E | No | EVA | |
| rs462400548 | 109 | T>P | No | EVA | |
| rs209786933 | 142 | L>V | No | EVA | |
| rs433693674 | 202 | L>F | No | EVA | |
| rs471191753 | 221 | P>S | No | EVA | |
| rs439876590 | 223 | F>V | No | EVA | |
| rs476898064 | 306 | E>D | No | EVA | |
| rs445435213 | 308 | V>G | No | EVA | |
| rs437474552 | 311 | L>V | No | EVA | |
| rs457526268 | 321 | V>G | No | EVA | |
| rs433028277 | 330 | S>* | No | EVA | |
| rs433028277 | 330 | S>L | No | EVA | |
| rs456093289 | 331 | V>F | No | EVA | |
| rs476216065 | 331 | V>G | No | EVA | |
| rs441704198 | 332 | F>L | No | EVA | |
| rs455375081 | 333 | K>E | No | EVA | |
| rs472270077 | 336 | A>V | No | EVA | |
| rs460720496 | 341 | H>Q | No | EVA | |
| rs440679591 | 341 | H>R | No | EVA | |
| rs477724559 | 342 | F>C | No | EVA | |
| rs477724559 | 342 | F>S | No | EVA | |
| rs462925275 | 346 | Q>* | No | EVA | |
| rs448383770 | 349 | F>S | No | EVA | |
| rs447428694 | 357 | E>Q | No | EVA | |
| rs464167099 | 366 | Y>F | No | EVA | |
| rs433065486 | 371 | P>S | No | EVA | |
| rs456379377 | 372 | Y>* | No | EVA | |
| rs469771665 | 374 | R>H | No | EVA | |
| rs472317608 | 375 | P>L | No | EVA | |
| rs455234453 | 375 | P>T | No | EVA | |
| rs480671907 | 539 | C>S | No | EVA | |
| rs721988529 | 548 | R>Q | No | EVA | |
| rs468342789 | 561 | L>P | No | EVA | |
| rs433844278 | 562 | T>P | No | EVA | |
| rs447253025 | 564 | C>G | No | EVA | |
| rs464080400 | 565 | R>* | No | EVA | |
| rs456275661 | 565 | R>S | No | EVA | |
| rs432871992 | 565 | R>T | No | EVA | |
| rs438240674 | 570 | K>Q | No | EVA | |
| rs455103728 | 570 | K>T | No | EVA | |
| rs440660592 | 571 | A>T | No | EVA | |
| rs720728096 | 622 | I>T | No | EVA | |
| rs463752941 | 626 | Q>* | No | EVA | |
| rs480990157 | 626 | Q>H | No | EVA | |
| rs449521629 | 641 | Y>N | No | EVA | |
| rs445179576 | 652 | Q>E | No | EVA | |
| rs437267649 | 664 | S>F | No | EVA | |
| rs436181640 | 666 | M>I | No | EVA | |
| rs467520813 | 666 | M>K | No | EVA | |
| rs453221936 | 667 | V>G | No | EVA | |
| rs473268395 | 668 | A>G | No | EVA | |
| rs438410112 | 671 | T>P | No | EVA | |
| rs451959707 | 690 | P>L | No | EVA | |
| rs475320974 | 707 | Q>H | No | EVA | |
| rs444054467 | 709 | C>F | No | EVA | |
| rs463795550 | 710 | K>T | No | EVA | |
| rs434766636 | 714 | Q>P | No | EVA | |
| rs453348945 | 717 | Q>L | No | EVA |
No associated diseases with A7MB70
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chemorepellent activity | Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. |
| semaphorin receptor binding | Binding to a semaphorin receptor. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| blood vessel remodeling | The reorganization or renovation of existing blood vessels. |
| cardiac endothelial to mesenchymal transition | A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes. |
| cardiac right ventricle morphogenesis | The process in which the right cardiac ventricle is generated and organized. |
| dichotomous subdivision of terminal units involved in salivary gland branching | The process in which a salivary epithelial cord bifurcates at its end. |
| limb bud formation | The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable. |
| negative chemotaxis | The directed movement of a motile cell or organism towards a lower concentration of a chemical. |
| negative regulation of axon extension involved in axon guidance | Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. |
| neural crest cell migration | The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. |
| neural tube development | The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. |
| outflow tract septum morphogenesis | The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. |
| positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis | Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| pulmonary myocardium development | The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein. |
| semaphorin-plexin signaling pathway | The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. |
| somitogenesis | The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFQAVCILV | GVFVCSTYVK | GSPQPQARVY | LTFDELRETK | TSEYFSLSQY | PLDYRILLMD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EDQDRMYVGS | KDHILSLNIN | NISQEPLSVF | WPASAIKVEE | CKMAGKDPTH | GCGNFVRVIQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AFNRTHLYVC | GSGAFSPVCA | YLNRGRRSED | QVFMIDSKCE | SGKGRCSFNP | NVNTVSVMIN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EELFSGMYID | FMGTDAAIFR | SLTKRNAVRT | DQHNSKWLSE | PMFVDAHVIP | DGTDPNDAKV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YFFFKEKLTD | NSRSTKQIHS | MIARICPNDT | GGLRSLVNKW | TTFLKARLVC | SVTDEDGPET |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HFDELEDVFL | LEMDNPRTTL | VYGIFTTSSS | VFKGSAVCVY | HFSDIQTVFN | GPFAHKEGPN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HQLISYQGRI | PYPRPGTCPG | GAFTPNMRTT | KEFPDDVVTF | IRNHPLMYNS | IYPVHRRPLI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VRIGTDYKYT | KIAVDRVNAA | DGTYNVLFLG | TDRGTVQKVV | VLPTNSSARS | ELILEELEVF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KNHAPITTMK | ISSKKQQLYV | SSNEGLAQVS | LHRCHIYGSA | CADCCLARDP | YCAWDGHSCS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RFYPTGKRRS | RRQDVRHGNP | LTQCRGFNLK | AYRNAAEIVQ | YGVKNNTTFL | ECAPKSPQAS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IKWLLQKDKD | RRKEVKLNER | IIATSQGLLI | RSVQDSDQGL | YHCIATENSF | KQTIAKINFK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VLDSEMVAVV | TDKWSPWTWA | SSVRALPFHP | KDIMGAFSHS | EMQMINQYCK | DTRQQHQQGE |
| 730 | 740 | 750 | |||
| ESQKMRGDYG | KLKALINSRK | SRNRRNQLPE | S |