O42237

PR
Gene name
SEMA3E (COLL5)
Protein name
Semaphorin-3E
Names
Collapsin-5, COLL-5
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:374089
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

720-785 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42237

Entry ID Method Resolution Chain Position Source
AF-O42237-F1 Predicted AlphaFoldDB

No variants for O42237

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O42237

No associated diseases with O42237

3 regional properties for O42237

Type Name Position InterPro Accession
domain Sema domain 36 - 520 IPR001627
domain Semaphorin 3E, Sema domain 53 - 523 IPR015513
domain PSI domain 522 - 577 IPR016201

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
chemorepellent activity Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.
neuropilin binding Binding to a member of the neuropilin family.
semaphorin receptor binding Binding to a semaphorin receptor.

7 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
negative chemotaxis The directed movement of a motile cell or organism towards a lower concentration of a chemical.
negative regulation of axon extension involved in axon guidance Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance.
neural crest cell migration The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
semaphorin-plexin signaling pathway The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A7MB70 SEMA3C Semaphorin-3C Bos taurus (Bovine) PR
Q13275 SEMA3F Semaphorin-3F Homo sapiens (Human) PR
O88632 Sema3f Semaphorin-3F Mus musculus (Mouse) PR
10 20 30 40 50 60
MLGRMASAQD LLILALCGLL LELPAGYHAT DTRQPRLRLS HKELWDLNRT SVFHSPFGYL
70 80 90 100 110 120
GLHIMLLDEY QERLFVGGRD LLYSLSLDRI SNNYREIHWP STPLQAEECI IKGRDADECA
130 140 150 160 170 180
NYVRVLHRYN RTHLLACGTG AFDPVCTFIR VGHPSEDHLF QLESHKFERG RGRCPFDPTS
190 200 210 220 230 240
SFTSILIGGE LFTGLYSDYW GRDAAVFRTM NRMAHLRTEP DSEHLLKEPK FVGSYMIPDN
250 260 270 280 290 300
EDHDDNKVYL FFTEKALEAE TSTHAIYTRV GRVCVNDMGG QRIVVNKWST FLKTRLVCSV
310 320 330 340 350 360
PGRNGIDTHF DELEDVFLLQ TRDNKNPVIF GLFSTTSNIF RGYAICVYHM AIVRAAFNGP
370 380 390 400 410 420
YAHKEGPEYY WALYEGKVPY PRPGSCASKV NGGLYTTTKD YPDEAVHFAR SHPLMYQPIK
430 440 450 460 470 480
PVHKRPILVK TDGKYNLKQI AVDRVEAEDG QYDVLFIGTD NGIVLKVITI YNQETESMEE
490 500 510 520 530 540
VILEELQVFK VPIPILSMEI SSKRQQLYIG TESVIAQVKF HQCDMYGTAC ADCCLARDPY
550 560 570 580 590 600
CAWDGISCSR YYPTGMQAKR RFRRQDVRHG NAAQQCFGQQ FIGEVLEKTE ERLVYGIEYN
610 620 630 640 650 660
STLLEYTPRT LQAKVNWFVQ RAHETKKEEV KTDERIIKMD LGLLFLKLHR LDAGTYFCQT
670 680 690 700 710 720
VEHSIVHTVR KITLEIVEEE RVDEMFSKDY EEEISHKMPC PMQSNIPQVS KPWYKEFLQL
730 740 750 760 770 780
IGYSNFQRVE EYCEKVWCTD KKRKKLKMSP SKWKYANPQE KRQDQEKKAR IRPEHYRLPR
NIADS