AiPD: Autoinhibited Protein Database

O75995

Gene name	SASH3 (CXorf9, SLY)
Protein name	SAM and SH3 domain-containing protein 3
Names	SH3 protein expressed in lymphocytes homolog
Species	Homo sapiens (Human)
KEGG Pathway	hsa:54440
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-286 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-286 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for O75995

Entry ID	Method	Resolution	Chain	Position	Source
AF-O75995-F1	Predicted				AlphaFoldDB

196 variants for O75995

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
VAR_087463	169	Q>del	IMD102; loss of protein expression [UniProt]	Yes	UniProt
VAR_087464	245	R>del	IMD102; loss of protein expression; patient T cells show decreased proliferation and cell cycle progression and increased apoptosis; functional signaling defects of the T cell receptor [UniProt]	Yes	UniProt
VAR_087465	288	R>del	IMD102; loss of protein expression; patient T cells show decreased proliferation and cell cycle progression and increased apoptosis; functional signaling defects of the T cell receptor [UniProt]	Yes	UniProt
VAR_087466	347	R>C	IMD102; decreased protein abundance; patient T cells show decreased proliferation and cell cycle progression and increased apoptosis; functional signaling defects of the T cell receptor [UniProt]	Yes	UniProt
rs368987935 CA10513143	3	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA10513144 rs150610485	3	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs749177330 CA335077848	4	R>C		No	ClinGen ExAC TOPMed gnomAD
rs749177330 CA10513146	4	R>G		No	ClinGen ExAC TOPMed gnomAD
rs768613358 CA10513147	4	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	5	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201637179 CA10513148	9	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	12	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761610241 CA10513149	13	E>D		No	ClinGen ExAC TOPMed gnomAD
rs375209867 CA335077861	15	T>I		No	ClinGen TOPMed
rs771742601 CA10513150	16	Q>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	17	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	20	L>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1184278025 CA414558166	25	S>C		No	ClinGen gnomAD
rs747933532 CA10513166	32	A>D		No	ClinGen ExAC
CA335082213 rs1024540394	32	A>T		No	ClinGen Ensembl
rs1478025381 CA414558279	34	S>F		No	ClinGen TOPMed
TCGA novel	38	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1602928141 CA414558308	39	P>T		No	ClinGen Ensembl
CA10513167 rs771809544	40	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	40	V>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1174652867 CA414558321	41	V>M		No	ClinGen gnomAD
rs1602928160 CA414558329	42	S>I		No	ClinGen Ensembl
TCGA novel	43	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1428400431 CA414558333	43	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	45	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414558350 rs1602928192	45	E>*		No	ClinGen Ensembl
rs1216818411 CA414558373	48	L>M		No	ClinGen TOPMed
TCGA novel	49	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414558398 rs1321217392	51	N>S		No	ClinGen TOPMed gnomAD
rs1188003459 CA414559714	54	E>D		No	ClinGen TOPMed gnomAD
TCGA novel	57	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1327445207 CA414559794	60	P>S		No	ClinGen gnomAD
CA414559807 rs1293367501	61	T>P		No	ClinGen TOPMed
rs777364769 CA10513189	64	D>G		No	ClinGen ExAC gnomAD
CA414559896 rs1405870549	65	A>D		No	ClinGen TOPMed
CA335082631 rs367931250	65	A>T		No	ClinGen ESP
TCGA novel	71	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414560063 rs1437178764	73	G>R		No	ClinGen gnomAD
CA414560165 rs1363923890	77	R>K		No	ClinGen TOPMed
rs375620085 CA335082640	78	A>V		No	ClinGen ESP TOPMed
CA414560248 rs1431433144	82	R>*		No	ClinGen TOPMed
rs745337836 CA10513193	82	R>Q		No	ClinGen ExAC gnomAD
CA10513194 COSM1114889 rs779253669	84	M>I	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA10513195 COSM3800396 rs775165842	91	M>T	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs763333259 CA10513196	92	M>I		No	ClinGen ExAC gnomAD
CA10513197 rs146852075	93	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1314045772 CA414560461	94	K>E		No	ClinGen gnomAD
rs1185978448 CA414560479	95	A>S		No	ClinGen gnomAD
TCGA novel	95	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774521851 CA10513198	97	S>T		No	ClinGen ExAC
rs1475227008 CA414560570	100	M>T		No	ClinGen gnomAD
CA414561003 rs1189430471	105	E>G		No	ClinGen gnomAD
CA10513215 rs748844612	106	E>K		No	ClinGen ExAC gnomAD
rs1159302727 CA414561027	107	G>S		No	ClinGen gnomAD
CA335084516 rs745609258	111	P>L		No	ClinGen TOPMed gnomAD
rs1390684699 CA414561137	114	P>A		No	ClinGen TOPMed
CA414561151 rs1164381774	114	P>L		No	ClinGen TOPMed
TCGA novel	119	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	119	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1158883108 CA414561442	123	P>L		No	ClinGen TOPMed
rs760819411 CA10513221	124	E>K		No	ClinGen ExAC TOPMed gnomAD
rs766601056 CA10513222	127	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA335084591 rs895315649	130	F>V		No	ClinGen TOPMed
CA414561770 rs1319147599	133	Q>E		No	ClinGen gnomAD
CA414561772 rs1232523286	133	Q>P		No	ClinGen gnomAD
CA10513225 rs140642583	134	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs150062353 CA10513226	139	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA414562015 rs1267266415	140	V>A		No	ClinGen TOPMed
CA10513228 rs781096781	140	V>M		No	ClinGen ExAC TOPMed gnomAD
CA10513229 rs200310644	141	L>F		No	ClinGen 1000Genomes ExAC
rs755774478 CA10513230	141	L>P		No	ClinGen ExAC
TCGA novel	141	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	142	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414562039 rs1479996252	142	S>R		No	ClinGen gnomAD
rs771879917 CA10513231	143	R>C		No	ClinGen ExAC TOPMed gnomAD
CA10513232 rs758842379	143	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs768254513 CA10513233	144	Q>H		No	ClinGen ExAC gnomAD
CA10513234 rs779266982	145	A>V		No	ClinGen ExAC gnomAD
rs1166590256 CA414562153	146	S>L		No	ClinGen gnomAD
rs772570347 CA10513236	147	T>I		No	ClinGen ExAC gnomAD
CA10513235 rs748612209	147	T>S		No	ClinGen ExAC
CA414562181 rs1461520484	148	G>S		No	ClinGen gnomAD
TCGA novel	151	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414562450 rs1268978699	152	C>*		No	ClinGen gnomAD
CA335085356 rs199679124	153	S>N		No	ClinGen 1000Genomes
CA10513251 rs369974398	155	S>N		No	ClinGen ESP ExAC gnomAD
COSM1682877 CA10513252 rs747669832	156	P>S	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA10513253 CA10513254 rs776424343	162	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10513256 rs373024115	164	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA414562672 rs1469690801	165	P>L		No	ClinGen gnomAD
TCGA novel	166	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10513257 COSM213049 rs149215914	166	P>S	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA
CA414562722 rs1227995573	168	P>L		No	ClinGen TOPMed
CA10513260 rs775657175	169	Q>H		No	ClinGen ExAC gnomAD
TCGA novel	169	Q>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	172	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763187338 CA10513261	174	F>Y		No	ClinGen ExAC gnomAD
rs1188139924 CA414562885	177	R>Q		No	ClinGen gnomAD
rs900176699 CA335085405	179	R>Q		No	ClinGen TOPMed gnomAD
CA335085416 rs1049213114	182	T>A		No	ClinGen Ensembl
CA10513264 rs760525860	183	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	185	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1602931863 CA414563047	186	P>S		No	ClinGen Ensembl
rs753577551 CA414563131	189	Y>*		No	ClinGen ExAC gnomAD
rs1432141495 CA414563163	191	H>Q		No	ClinGen TOPMed gnomAD
TCGA novel	192	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10513267 rs754599102	193	S>L		No	ClinGen ExAC gnomAD
TCGA novel	196	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs868594208 CA335085554	198	K>E		No	ClinGen Ensembl
TCGA novel	199	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA335085565 rs967959753	199	G>R		No	ClinGen TOPMed gnomAD
CA414565786 rs1231102806	207	K>E		No	ClinGen TOPMed
rs1444165550 CA414565861	209	P>S		No	ClinGen gnomAD
rs1331067659 CA414565981	212	T>M		No	ClinGen TOPMed
TCGA novel	214	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1232497430 CA414566133	217	L>I		No	ClinGen gnomAD
CA10513287 rs746630084	221	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	226	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414566663 rs1393586292	231	V>E		No	ClinGen gnomAD
CA335085601 rs1031439816	231	V>M		No	ClinGen TOPMed
rs1407680518 CA414566851	237	V>A		No	ClinGen gnomAD
CA10513290 rs200789186	237	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA414566884 rs1397036940	239	H>N		No	ClinGen TOPMed gnomAD
rs757728623 CA10513291	239	H>Q		No	ClinGen ExAC gnomAD
rs2231131 CA10513292	240	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA414566947 rs1444194777	241	R>C		No	ClinGen TOPMed gnomAD
rs1444194777 CA414566945	241	R>G		No	ClinGen TOPMed gnomAD
CA10513293 rs750800867 COSM284790	241	R>H	kidney Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
RCV000906380 CA10513294 rs147976313	244	R>C		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10513295 rs751943834	244	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA414567047 rs751943834	244	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10513296 rs35096611	245	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	252	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs975557861 CA335085708	252	P>R		No	ClinGen Ensembl
CA10513300 rs770896257	258	H>P		No	ClinGen ExAC gnomAD
rs920145333 CA335085722	258	H>Y		No	ClinGen Ensembl
CA10513301 rs776473635	263	R>C		No	ClinGen ExAC TOPMed gnomAD
rs759348769 CA10513302	263	R>H		No	ClinGen ExAC gnomAD
CA10513304 rs145839385	265	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA335085901 COSM72538 rs1044927153	270	T>I	ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs755236916 CA10513315	273	L>F		No	ClinGen ExAC TOPMed gnomAD
CA10513318 rs758452425	286	E>D		No	ClinGen ExAC gnomAD
CA10513319 rs777927882 COSM1114892	288	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA414569059 rs1318843175	289	E>D		No	ClinGen gnomAD
rs1213036765 CA414569102	290	T>I		No	ClinGen TOPMed
rs138840040 CA335085927 CA10513320	291	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	292	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414569213 rs1401898927	293	N>S		No	ClinGen gnomAD
rs868200701 CA335085928	298	M>I		No	ClinGen TOPMed gnomAD
CA335085941 rs1030989164	302	H>Q		No	ClinGen Ensembl
CA10513323 rs749142379	303	R>Q		No	ClinGen ExAC TOPMed gnomAD
RCV000413458 rs1057518320	305	K>missing		No	ClinVar dbSNP
TCGA novel	306	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773919719 COSM1114893 CA10513325	308	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA335086010 rs866985797	309	A>T		No	ClinGen Ensembl
rs772811145 CA10513328	310	A>T		No	ClinGen ExAC gnomAD
CA414569946 rs1452744185	311	E>*		No	ClinGen gnomAD
rs1452744185 CA414569935	311	E>K		No	ClinGen gnomAD
rs1210922686 CA414570520	320	S>C		No	ClinGen TOPMed
CA414570549 rs1379517201	320	S>N		No	ClinGen gnomAD
TCGA novel	322	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs896586967 CA335086223	325	E>Q		No	ClinGen TOPMed
CA10513356 rs138105032	327	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA10513358 rs754943660	329	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1569313803 CA414571046	331	Q>P		No	ClinGen Ensembl
rs1000983863 CA335086272	332	E>K		No	ClinGen TOPMed gnomAD
CA10513359 rs778508257	333	P>L		No	ClinGen ExAC TOPMed gnomAD
CA414571152 rs1239797370 COSM1224695	334	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA10513360 rs747991939	336	H>Q		No	ClinGen ExAC
CA10513362 rs149530194	339	S>L		No	ClinGen ESP ExAC
rs776311788 CA10513366	340	E>Q		No	ClinGen ExAC gnomAD
rs758514745 CA10513368	341	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1332251707 CA414571461	343	V>M		No	ClinGen gnomAD
rs1374058569 CA414571608	346	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA414571628 rs1439129682	347	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs762045557 CA10513373	355	S>L		No	ClinGen ExAC TOPMed gnomAD
CA10513372 rs751829685	355	S>T		No	ClinGen ExAC TOPMed gnomAD
CA10513376 rs754816732	358	G>R		No	ClinGen ExAC gnomAD
TCGA novel	359	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414572099 rs1480881072	359	R>H		No	ClinGen TOPMed
rs752401302 CA10513378	360	D>G		No	ClinGen ExAC
CA414572124 rs1569313861	360	D>Y		No	ClinGen Ensembl
rs143706986 CA335086396	361	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs377512781 CA10513380	362	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA414572395 rs1442392976	367	T>I		No	ClinGen gnomAD
CA10513382 rs770710833	368	E>A		No	ClinGen ExAC gnomAD
TCGA novel	374	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10513383 rs780790088	376	L>V		No	ClinGen ExAC gnomAD
rs1357509082 CA414572700	377	A>D		No	ClinGen TOPMed
CA414572712 rs1426031174	378	G>R		No	ClinGen gnomAD
CA10513388 rs770200497	379	A>S		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with O75995

3 regional properties for O75995

Type	Name	Position	InterPro Accession
domain	SH3 domain	173 - 234	IPR001452
domain	Sterile alpha motif domain	249 - 316	IPR001660
domain	SAM and SH3 domain-containing protein 3, SH3 domain	176 - 231	IPR035721

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

17 GO annotations of biological process

Name	Definition
B cell homeostasis	The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
B cell proliferation	The expansion of a B cell population by cell division. Follows B cell activation.
CD4-positive, alpha-beta T cell differentiation	The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
homeostasis of number of cells within a tissue	Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.
positive regulation of adaptive immune response	Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
positive regulation of B cell proliferation	Any process that activates or increases the rate or extent of B cell proliferation.
positive regulation of CD4-positive, alpha-beta T cell differentiation	Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.
positive regulation of immunoglobulin production	Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
positive regulation of interferon-gamma production	Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
positive regulation of interleukin-10 production	Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
positive regulation of interleukin-2 production	Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
positive regulation of interleukin-4 production	Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
positive regulation of organ growth	Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.
positive regulation of T cell cytokine production	Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.
positive regulation of T cell proliferation	Any process that activates or increases the rate or extent of T cell proliferation.
positive regulation of tumor necrosis factor production	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
T cell proliferation	The expansion of a T cell population by cell division. Follows T cell activation.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A0JN71	SASH3	SAM and SH3 domain-containing protein 3	Bos taurus (Bovine)	PR
Q8K352	Sash3	SAM and SH3 domain-containing protein 3	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MLRRKPSNAS	EKEPTQKKKL	SLQRSSSFKD	FAKSKPSSPV	VSEKEFNLDD	NIPEDDSGVP
70	80	90	100	110	120
TPEDAGKSGK	KLGKKWRAVI	SRTMNRKMGK	MMVKALSEEM	ADTLEEGSAS	PTSPDYSLDS
130	140	150	160	170	180
PGPEKMALAF	SEQEEHELPV	LSRQASTGSE	LCSPSPGSGS	FGEEPPAPQY	TGPFCGRARV
190	200	210	220	230	240
HTDFTPSPYD	HDSLKLQKGD	VIQIIEKPPV	GTWLGLLNGK	VGSFKFIYVD	VLPEEAVGHA
250	260	270	280	290	300
RPSRRQSKGK	RPKPKTLHEL	LERIGLEEHT	STLLLNGYQT	LEDFKELRET	HLNELNIMDP
310	320	330	340	350	360
QHRAKLLTAA	ELLLDYDTGS	EEAEEGAESS	QEPVAHTVSE	PKVDIPRDSG	CFEGSESGRD
370
DAELAGTEEQ	LQGLSLAGAP